Development of bioflavonoid containing chemotherapeutic delivery systems for UV-damaged skin and kangri cancer
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Oct 23, 2022
About this article
Article Category: Research Article
Published Online: Oct 23, 2022
Page range: 86 - 98
Received: Nov 06, 2021
Accepted: Jan 26, 2022
DOI: https://doi.org/10.2478/fco-2021-0012
Keywords
© 2021 Harish Sharma et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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pH of prepared microemulsion batches_
| RME1 | 5.24 |
| RME2 | 5.93 |
| RME3 | 5.67 |
Ingredients list for preparation of FU microemulsion_
| 5-FU | Drug |
| Tween 20 | Surfactant |
| Isopropyl alcohol | Cosurfactant |
| Isopropyl myristate | Oil |
| DMSO | Penetration enhancer |
| Rutin | Antioxidant |
Values of drug permeation of prepared microemulsion batches_
| 0.128 | 0.128 | 0.135 | 0.138 | |
| 0.130 | 0.145 | 0.152 | 0.156 | |
| 0.161 | 0.165 | 0.174 | 0.178 | |
| 0.182 | 0.193 | 0.203 | 0.208 | |
| 0.217 | 0.232 | 0.244 | 0.251 | |
| 0.275 | 0.291 | 0.305 | 0.312 | |
| 0.358 | 0.386 | 0.406 | 0.416 | |
| 0.510 | 0.581 | 0.61 | 0.625 | |
| 1.012 | 1.161 | 1.22 | 1.25 | |
| 1.012 | 1.161 | 1.22 | 1.25 | |
Solubility of R-5FU in different oils, surfactants and co-surfactants_
| Isopropyl myristate | 165.28 |
| Oleic acid | 183.12 |
| Castor oil | 44.26 |
| Olive oil | 32.61 |
| Tween 80 | 105.28 |
| Tween 20 | 93.12 |
| Span 80 | 58.27 |
| Span 20 | 31.62 |
| Isopropyl alcohol | 107.28 |
| Ethanol | 43.12 |
| N-butanol | 58.27 |
| Polyethylene glycol | 69.62 |
| Propylene glycol | 79.62 |
Scoring for irritation testing (HET-CAM assay)_
| Lysis | -- | -- | -- | 0 | Non-irritant | |
| Hemorrhage | -- | -- | -- | |||
| Coagulation | -- | -- | -- | |||
| Lysis | - | -- | -- | 0 | Non-irritant | |
| Hemorrhage | -- | -- | -- | |||
| Coagulation | -- | -- | -- | |||
| Lysis | -- | -- | -- | 0 | Non-irritant | |
| Hemorrhage | -- | -- | -- | |||
| Coagulation | -- | -- | -- | |||
| Lysis | -- | -- | -- | 0 | non-irritant | |
| Hemorrhage | -- | -- | -- | |||
| Coagulation | -- | -- | -- | |||
| Lysis | -- | 7 | -- | 23 | Severe-irritant | |
| Hemorrhage | 7 | -- | -- | |||
| Coagulation | 9 | -- | -- | |||
Effects of RME1, RME2, RME3, control and irritant on chorioallantoic membrane with different time interval_
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Mean erythemal score evaluated for different formulation_
| 2 | 5 | 7 | 10 | 14 | 18 | 21 | |
| 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 0 | 0 | 0 | 0 | 0 | 0 | 1 | |
| 0 | 0 | 0 | 0 | 0 | 1 | 1 | |
| 0 | 0 | 0 | 0 | 0 | 1 | 1 | |
| 0 | 0 | 1 | 1 | 2 | 3 | 3 | |
Viscosity of prepared microemulsion batches_
| RME1 | 14.68 |
| RME2 | 16.52 |
| RME3 | 17.25 |