<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3><p>The lower abdomen and inner thighs are most likely to become affected by kangri cancer because those areas are exposed to continuous exposure to kangri.</p></sec>
<sec><h3>Objective</h3><p>In this article, formulation and characterization of a water-in-oil microemulsion of 5-fluorouracil with rutin (R-5FU) for better skin penetration and inhibition of kangri cancer (skin cancer surfactant) is discussed.</p></sec>
<sec><h3>Method</h3><p>To produce R-5-FU microemulsions, surfactant-cosurfactant was mixed with oil. Distilled water was added dropwise with the help of a burette by gentle stirring at a constant temperature. The surfactant and co-surfactant were mixed into three particular ratios 1:1, 2:1, and 3:1. Further characterizations were performed, such as visual inspection and thermodynamic stability including a stress test and centrifugation. In visual inspection included assessment of the colour, homogeneity, and odour of the formulation of FU microemulsion.</p></sec>
<sec><h3>Result</h3><p>All three microemulsions, labeled RME1, RME2, and RME3, are highly stable. An oval shape of surface morphology of 5-FU was noticed by using a TEM image. The viscosity of RME3 was found to be 17.25±0.22 pa-s. The average globule size was 100–300 nm for all three RME. The results of human cadaver skin permeability are almost of the same pattern, butRME3 indicates the best skin permeability with negligible side effects on the skin.</p></sec>
<sec><h3>Conclusion</h3><p>The quantity of 5-FU released from all formulations at 3-hr ranged from 95.57% to 83.67%. None of the three formulations resulted in skin irritation, with irritancy score of zero (IS=0). Observation revealed no lysis, hemorrhage, or coagulation after application.</p></sec>
</abstract>

BackgroundThe lower abdomen and inner thighs are most likely to become affected by kangri cancer because those areas are exposed to continuous exposure to kangri.
ObjectiveIn this article, formulation and characterization of a water-in-oil microemulsion of 5-fluorouracil with rutin (R-5FU) for better skin penetration and inhibition of kangri cancer (skin cancer surfactant) is discussed.
MethodTo produce R-5-FU microemulsions, surfactant-cosurfactant was mixed with oil. Distilled water was added dropwise with the help of a burette by gentle stirring at a constant temperature. The surfactant and co-surfactant were mixed into three particular ratios 1:1, 2:1, and 3:1. Further characterizations were performed, such as visual inspection and thermodynamic stability including a stress test and centrifugation. In visual inspection included assessment of the colour, homogeneity, and odour of the formulation of FU microemulsion.
ResultAll three microemulsions, labeled RME1, RME2, and RME3, are highly stable. An oval shape of surface morphology of 5-FU was noticed by using a TEM image. The viscosity of RME3 was found to be 17.25±0.22 pa-s. The average globule size was 100–300 nm for all three RME. The results of human cadaver skin permeability are almost of the same pattern, butRME3 indicates the best skin permeability with negligible side effects on the skin.
ConclusionThe quantity of 5-FU released from all formulations at 3-hr ranged from 95.57% to 83.67%. None of the three formulations resulted in skin irritation, with irritancy score of zero (IS=0). Observation revealed no lysis, hemorrhage, or coagulation after application.

Development of bioflavonoid containing chemotherapeutic delivery systems for UV-damaged skin and kangri cancer

Rungta College of Pharmaceutical Sciences and Research

Forum of Clinical Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundThe lower abdomen and inner thighs are most likely to become affected by kangri cancer because those areas are exposed to continuous exposure to...

Development of bioflavonoid containing chemotherapeutic delivery systems for UV-damaged skin and kangri cancer

Article Category: Research Article

Published Online: Oct 23, 2022

Page range: 86 - 98

Received: Nov 06, 2021

Accepted: Jan 26, 2022

DOI: https://doi.org/10.2478/fco-2021-0012

Keywords
5-fluorouracil, HET-CAM assay, Kangri cancer, microemulsion, rutin, stability

© 2021 Harish Sharma et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Development of bioflavonoid containing chemotherapeutic delivery systems for UV-damaged skin and kangri cancer

Article Category: Research Article

Published Online: Oct 23, 2022

Page range: 86 - 98

Received: Nov 06, 2021

Accepted: Jan 26, 2022

DOI: https://doi.org/10.2478/fco-2021-0012

Keywords5-fluorouracil, HET-CAM assay, Kangri cancer, microemulsion, rutin, stability

© 2021 Harish Sharma et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
5-fluorouracil, HET-CAM assay, Kangri cancer, microemulsion, rutin, stability