<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective.</bold> The present study sought to verify the effects of an exercise training on the memory along with the morphological assessment of the adrenal gland tissue in the rats with experimental autoimmune encephalomyelitis (EAE).
<bold>Methods.</bold> Female Lewis rats were randomly divided into three groups: EAE group, EAE group with exercise (EAE+Ex), and control group (CO). Each group contained 10 rats. To evaluate the memory, all rats were subjected to the Morris water maze learning test for four consecutive days and one day for a prop test. EAE was induced by guinea pig spinal cord homogenate emulsified in incomplete Freund’s adjuvant and heat-mycobacterium. The exercise training on a motorized treadmill was initiated 3 weeks before EAE induction and disconnected 2 weeks post-induction.
<bold>Results.</bold> We found that exercise training for five weeks produced an improved swimming velocity related to memory improvement in EAE+Ex group in comparison with EAE group, but not an incurable adrenal gland tissue after EAE induction.
<bold>Conclusions.</bold> The experimental design selected for this study appears to be an effective treatment for memory in rats with experimental autoimmune encephalomyelitis.
</abstract>

Objective. The present study sought to verify the effects of an exercise training on the memory along with the morphological assessment of the adrenal gland tissue in the rats with experimental autoimmune encephalomyelitis (EAE).
Methods. Female Lewis rats were randomly divided into three groups: EAE group, EAE group with exercise (EAE+Ex), and control group (CO). Each group contained 10 rats. To evaluate the memory, all rats were subjected to the Morris water maze learning test for four consecutive days and one day for a prop test. EAE was induced by guinea pig spinal cord homogenate emulsified in incomplete Freund’s adjuvant and heat-mycobacterium. The exercise training on a motorized treadmill was initiated 3 weeks before EAE induction and disconnected 2 weeks post-induction.
Results. We found that exercise training for five weeks produced an improved swimming velocity related to memory improvement in EAE+Ex group in comparison with EAE group, but not an incurable adrenal gland tissue after EAE induction.
Conclusions. The experimental design selected for this study appears to be an effective treatment for memory in rats with experimental autoimmune encephalomyelitis.

Exercise training improves memory and produces changes in the adrenal gland morphology in the experimental autoimmune encephalomyelitis

Department of Exercise Physiology, Faculty of Sport Sciences

Endocrine Regulations

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Objective. The present study sought to verify the effects of an exercise training on the memory along with the morphological assessment of the adrenal gland...

Exercise training improves memory and produces changes in the adrenal gland morphology in the experimental autoimmune encephalomyelitis

Published Online: Feb 18, 2022

Page range: 31 - 37

DOI: https://doi.org/10.2478/enr-2022-0004

Keywords
exercise training, EAE model, memory, adrenal gland

© 2022 Muthanna Hafedh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Exercise training improves memory and produces changes in the adrenal gland morphology in the experimental autoimmune encephalomyelitis

Published Online: Feb 18, 2022

Page range: 31 - 37

DOI: https://doi.org/10.2478/enr-2022-0004

Keywordsexercise training, EAE model, memory, adrenal gland

© 2022 Muthanna Hafedh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
exercise training, EAE model, memory, adrenal gland