New strategies for the control of infectious and parasitic diseases in blood donors: the impact of pathogen inactivation methods
and
Apr 30, 2020
About this article
Article Category: Review
Published Online: Apr 30, 2020
Page range: 53 - 66
DOI: https://doi.org/10.2478/ebtj-2020-0007
Keywords
© 2020 Luca Galli and Fabrizio Bruschi, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
Around 70 infectious agents are possible threats for blood safety.
The risk for blood recipients is increasing because of new emergent agents like West Nile, Zika and Chikungunya viruses, or parasites such as
Screening programmes of the donors are more and more implemented in several Countries, but these cannot prevent completely infections, especially when they are caused by new agents.
Pathogen inactivation (PI) methods might overcome the limits of the screening and different technologies have been set up in the last years.
This review aims to describe the most widely used methods focusing on their efficacy as well as on the preservation integrity of blood components.