This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
World Health Oranization (WHO): Report on the Global Tobacco Epidemic, 2021: Addressing New and Emerging Products; WHO, Geneva, Switzerland, 2021.World Health Oranization (WHO):Report on the Global Tobacco Epidemic, 2021:Addressing New and Emerging Products;WHO,Geneva, Switzerland,2021.Search in Google Scholar
U.S. Food & Drug Administration (FDA): Modified Risk Tobacco Product Applications - Draft Guidance for Industry, April 2012; Docket Number: FDA-2012-D-0071U.S. Food & Drug Administration (FDA):Modified Risk Tobacco Product Applications - Draft Guidance for Industry,April2012;Docket Number: FDA-2012-D-0071Search in Google Scholar
Smith, M.R., B. Clark, F. Luedicke, J.P. Schaller, P. Vanscheeuwijck, J. Hoeng, and M.C. Peitsch: Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the System and the Scientific Assessment Program; Regul. Toxicol. Pharmacol. 81 (2016) S17–S26. DOI: 10.1016/j.yrtph.2016.07.006SmithM.R.ClarkB.LuedickeF.SchallerJ.P.VanscheeuwijckP.HoengJ. and PeitschM.C.:Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the System and the Scientific Assessment Program;Regul. Toxicol. Pharmacol.81(2016)S17–S26. DOI:10.1016/j.yrtph.2016.07.006Open DOISearch in Google Scholar
Eaton, D., B. Jakaj, M. Forster, J. Nicol, E. Mavropoulou, K. Scott, C. Liu, K. McAdam, J. Murphy, and C.J. Proctor: Assessment of Tobacco Heating Product THP1.0. Part 2: Product Design, Operation and Thermophysical Characterization; Regul. Toxicol. Pharmacol. 93 (2018) 4–13. DOI: 10.1016/j.yrtph.2017.09.009EatonD.JakajB.ForsterM.NicolJ.MavropoulouE.ScottK.LiuC.McAdamK.MurphyJ. and ProctorC.J.:Assessment of Tobacco Heating Product THP1.0. Part 2: Product Design, Operation and Thermophysical Characterization;Regul. Toxicol. Pharmacol.93(2018)4–13. DOI:10.1016/j.yrtph.2017.09.009Open DOISearch in Google Scholar
Baker, R.R.: Smoke Chemistry; in: Tobacco. Production, Chemistry and Technology; edited by D.L. Davis and M.T. Nielsen, Blackwell Science, Oxford (1999) 398–439. ISBN: 978-0-632-04791-8BakerR.R.:Smoke Chemistry; in:Tobacco. Production, Chemistry and Technology; edited byDavisD.L. and NielsenM.T.,Blackwell Science,Oxford(1999)398–439.ISBN: 978-0-632-04791-8Search in Google Scholar
Schaller, J.P., D. Keller, L. Poget, P. Pratte, E. Kaelin, D. McHugh, G. Cudazzo, D. Smart, A.R. Tricker, L. Gautier, M. Yerly, R. Reis Pires, S. Le Bouhellec, D. Ghosh, E. Garcia, I. Hofer, P. Vanscheeuwijck, and S. Maeder: Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aerosol; Regul. Toxicol. Pharmacol. 81 Suppl 2 (2016) S27-S47. DOI: 10.1016/j.yrtph.2016.10.001SchallerJ.P.KellerD.PogetL.PratteP.KaelinE.McHughD.CudazzoG.SmartD.TrickerA.R.GautierL.YerlyM.Reis PiresR.Le BouhellecS.GhoshD.GarciaE.HoferI.VanscheeuwijckP. and MaederS.:Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aerosol;Regul. Toxicol. Pharmacol.81Suppl 2(2016)S27-S47. DOI:10.1016/j.yrtph.2016.10.001Open DOISearch in Google Scholar
Forster, M., S. Fiebelkorn, C. Yurteri, D. Mariner, C. Liu, C. Wright, K. McAdam, J. Murphy, and C. Proctor: Assessment of Novel Tobacco Heating Product THP1.0. Part 3: Comprehensive Chemical Characterisation of Harmful and Potentially Harmful Aerosol Emissions; Regul. Toxicol. Pharmacol. 93 (2018) 14–33. DOI: 10.1016/j.yrtph.2017.10.006ForsterM.FiebelkornS.YurteriC.MarinerD.LiuC.WrightC.McAdamK.MurphyJ. and ProctorC.:Assessment of Novel Tobacco Heating Product THP1.0. Part 3: Comprehensive Chemical Characterisation of Harmful and Potentially Harmful Aerosol Emissions;Regul. Toxicol. Pharmacol.93(2018)14–33. DOI:10.1016/j.yrtph.2017.10.006Open DOISearch in Google Scholar
Li, B., Y. Sun, L.L. Fu, L.L. Feng, P. Lei, C. Liu, J.M. Han, S.Z. Shang, S. Wang, L. Wang, Y.H. Pan, Q. Zhang, Z.Y. Guo, F. Huang, M.J. Zhang, J.G. Tang, B. Wang, and K. Zhang: Aerosol Formation and Transfer in Open-and Closed-Ended Heated Tobacco Products; Contrib. Tob. Nicotine Res. 31 (2022) 162–174. DOI: 10.2478/cttr-2022-0017LiB.SunY.FuL.L.FengL.L.LeiP.LiuC.HanJ.M.ShangS.Z.WangS.WangL.PanY.H.ZhangQ.GuoZ.Y.HuangF.ZhangM.J.TangJ.G.WangB. and ZhangK.:Aerosol Formation and Transfer in Open-and Closed-Ended Heated Tobacco Products;Contrib. Tob. Nicotine Res.31(2022)162–174. DOI:10.2478/cttr-2022-0017Open DOISearch in Google Scholar
Guo, Z., S. Wang, K. Zhang, P. Lei, L.L. Fu, Q. Zhang, S.Z. Shang, S. Wang, L. Wang, M.J. Zhang, W.M. Gong, J.M. Han, Z.Q. Li, Y.H. Pan, F. Huang, C. Liu, J.G. Tang, B. Wang, and B. Li: Thermal De Oxygenation to Form Condensable Aerosol from Reconstituted Tobacco without Auto-Ignition; Contrib. Tob. Nicotine Res. 31 (2022) 130–141. DOI: 10.2478/cttr-2022-0014GuoZ.WangS.ZhangK.LeiP.FuL.L.ZhangQ.ShangS.Z.WangS.WangL.ZhangM.J.GongW.M.HanJ.M.LiZ.Q.PanY.H.HuangF.LiuC.TangJ.G.WangB. and LiB.:Thermal De Oxygenation to Form Condensable Aerosol from Reconstituted Tobacco without Auto-Ignition;Contrib. Tob. Nicotine Res.31(2022)130–141. DOI:10.2478/cttr-2022-0014Open DOISearch in Google Scholar
Schorp, M.K., A.R. Tricker, and R. Dempsey: Reduced Exposure Evaluation of an Electrically Heated Cigarette Smoking System. Part 1: Non-Clinical and Clinical Insights; Regul. Toxicol. Pharmacol. 64 (2012) S1–S10. DOI: 10.1016/j.yrtph.2012.08.008SchorpM.K.TrickerA.R. and DempseyR.:Reduced Exposure Evaluation of an Electrically Heated Cigarette Smoking System. Part 1: Non-Clinical and Clinical Insights;Regul. Toxicol. Pharmacol.64(2012)S1–S10. DOI:10.1016/j.yrtph.2012.08.008Open DOISearch in Google Scholar
Piadé, J.J., S. Wajrock, G. Jaccard, and G. Janeke: Formation of Mainstream Cigarette Smoke Constituents Prioritized by the World Health Organization – Yield Patterns Observed in Market Surveys, Clustering and Inverse Correlations; Food Chem. Toxicol. 55 (2013) 329–347. DOI: 0.1016/j.fct.2013.01.016PiadéJ.J.WajrockS.JaccardG. and JanekeG.:Formation of Mainstream Cigarette Smoke Constituents Prioritized by the World Health Organization – Yield Patterns Observed in Market Surveys, Clustering and Inverse Correlations;Food Chem. Toxicol.55(2013)329–347. DOI: 0.1016/j.fct.2013.01.016Open DOISearch in Google Scholar
International Organization for Standardization (ISO): ISO 10315:2013 Cigarettes — Determination of Nicotine in Smoke Condensates — Gas Chromatographic Method; ISO, Geneva, Switzeland, 2013. Available at: https://www.iso.org/standard/56744.html (accessed November 2023)International Organization for Standardization (ISO):ISO 10315:2013 Cigarettes — Determination of Nicotine in Smoke Condensates — Gas Chromatographic Method;ISO,Geneva, Switzeland,2013.Available at: https://www.iso.org/standard/56744.html(accessed November 2023)Search in Google Scholar
International Organization for Standardization (ISO): ISO 8454:2007 Cigarettes — Determination of Carbon Monoxide in the Vapour Phase of Cigarette Smoke — NDIR Method; ISO, Geneva, Switzerland, 2007. Available at: https://www.iso.org/standard/41168.html (accessed November 2023)International Organization for Standardization (ISO):ISO 8454:2007 Cigarettes — Determination of Carbon Monoxide in the Vapour Phase of Cigarette Smoke — NDIR Method;ISO,Geneva, Switzerland,2007.Available at: https://www.iso.org/standard/41168.html(accessed November 2023)Search in Google Scholar
Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA): CORESTA Recommended Method No. 91: Determination of 15 PAHs in Tobacco and Tobacco Products by GC-MS/MS or GC-MS; CORESTA, Paris, France, 2019. Available at: https://www.coresta.org/determination-15-pahs-tobacco-and-tobacco-products-gc-msms-or-gc-ms-32371.html (accessed November 2023)Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA):CORESTA Recommended Method No. 91:Determination of 15 PAHs in Tobacco and Tobacco Products by GC-MS/MS or GC-MS;CORESTA,Paris, France,2019.Available at: https://www.coresta.org/determination-15-pahs-tobacco-and-tobacco-products-gc-msms-or-gc-ms-32371.html(accessed November 2023)Search in Google Scholar
Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA): CORESTA Recommended Method No. 75: Determination of Tobacco Specific Nitrosamines in Mainstream Smoke by LC-MS/MS; CORESTA, Paris, France, 2022. Available at: https://www.coresta.org/determination-tobacco-specific-nitrosamines-mainstream-smoke-lc-msms-29198.html (accessed November 2023)Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA):CORESTA Recommended Method No. 75:Determination of Tobacco Specific Nitrosamines in Mainstream Smoke by LC-MS/MS;CORESTA,Paris, France,2022.Available at: https://www.coresta.org/determination-tobacco-specific-nitrosamines-mainstream-smoke-lc-msms-29198.html(accessed November 2023)Search in Google Scholar
World Health Oranization (WHO): WHO TobLabNet Official Method SOP 09. Standard Operating Procedure for Determination of Volatile Organics in Mainstream Cigarette Smoke Under ISO and Intense Smoking Conditions; WHO, Geneva, Switzerland, 2018. Available at: https://www.who.int/publications/i/item/standard-operating-procedure-for-determination-of-volatile-organics-in-mainstream-cigarette-smoke-under-iso-and-intense-smoking-conditions (accessed November 2023)World Health Oranization (WHO):WHO TobLabNet Official Method SOP 09.Standard Operating Procedure for Determination of Volatile Organics in Mainstream Cigarette Smoke Under ISO and Intense Smoking Conditions;WHO,Geneva, Switzerland,2018.Available at: https://www.who.int/publications/i/item/standard-operating-procedure-for-determination-of-volatile-organics-in-mainstream-cigarette-smoke-under-iso-and-intense-smoking-conditions(accessed November 2023)Search in Google Scholar
World Health Oranization (WHO): WHO TobLabNet Official Method SOP 08. Standard Operating Procedure for Determination of Aldehydes in Mainstream Cigarette Smoke Under ISO and Intense Smoking Conditions; WHO, Geneva, Switzerland, 2018. Available at: https://www.who.int/publications/i/item/standard-operating-procedure-for-determination-of-aldehydes-in-mainstream-cigarette-smoke-under-iso-and-intense-smoking-conditions (accessed November 2023)World Health Oranization (WHO):WHO TobLabNet Official Method SOP 08.Standard Operating Procedure for Determination of Aldehydes in Mainstream Cigarette Smoke Under ISO and Intense Smoking Conditions;WHO,Geneva, Switzerland,2018.Available at: https://www.who.int/publications/i/item/standard-operating-procedure-for-determination-of-aldehydes-in-mainstream-cigarette-smoke-under-iso-and-intense-smoking-conditions(accessed November 2023)Search in Google Scholar
Health Canada: Health Canada Official Method T-501. Bacterial Reverse Mutation Assay for Mainstream Tobacco Smoke; Available at: https://www.canada.ca/en/health-canada/services/publications/healthy- living/tobacco-methods-intake-2017/t-500/bacterial-reverse-mutation-assay-mainstream-tobacco-smoke.html (accessed November 2023)Health Canada:Health Canada Official Method T-501.Bacterial Reverse Mutation Assay for Mainstream Tobacco Smoke;Available at: https://www.canada.ca/en/health-canada/services/publications/healthy-living/tobacco-methods-intake-2017/t-500/bacterial-reverse-mutation-assay-mainstream-tobacco-smoke.html(accessed November 2023)Search in Google Scholar
Health Canada: Health Canada Official Method T-503. In Vitro Micronucleus Assay for Mainstream Tobacco Smoke; Available at: https://www.canada.ca/en/health-canada/services/publications/healthy-living/tobacco-methods-intake-2017/t-500/in-vitro-micronucleaus-assay-mainstream-tobacco-smoke.html (accessed November 2023)Health Canada:Health Canada Official Method T-503.In Vitro Micronucleus Assay for Mainstream Tobacco Smoke;Available at: https://www.canada.ca/en/health-canada/services/publications/healthy-living/tobacco-methods-intake-2017/t-500/in-vitro-micronucleaus-assay-mainstream-tobacco-smoke.html(accessed November 2023)Search in Google Scholar
Health Canada: Health Canada Official Method T-502. Neutral Red Uptake Assay for Mainstream Tobacco Smoke; Available at: https://www.canada.ca/en/health-canada/services/publications/healthy-living/tobacco-methods-intake-2017/t-500/neutral-red-assay-mainstream-tobacco-smoke.html (accessed November 2023)Health Canada:Health Canada Official Method T-502.Neutral Red Uptake Assay for Mainstream Tobacco Smoke;Available at: https://www.canada.ca/en/health-canada/services/publications/healthy-living/tobacco-methods-intake-2017/t-500/neutral-red-assay-mainstream-tobacco-smoke.html(accessed November 2023)Search in Google Scholar
Borenfreund, E. and J.A. Puerner: Toxicity Determined in Vitro by Morphological Alterations and Neutral Red Absorption; Toxicol. Lett. 24 (1985) 119-124. DOI: 10.1016/0378-4274(85)90046-3BorenfreundE. and PuernerJ.A.:Toxicity Determined in Vitro by Morphological Alterations and Neutral Red Absorption;Toxicol. Lett.24(1985)119-124. DOI:10.1016/0378-4274(85)90046-3Open DOISearch in Google Scholar
Torikai, K., Y. Uwano, T. Nakamori, W. Tarora, and H. Takahashi: Study on Tobacco Components Involved in the Pyrolytic Generation of Selected Smoke Constituents; Food Chem. Toxicol. 43 (2005) 559–568. DOI: 10.1016/j.fct.2004.12.011TorikaiK.UwanoY.NakamoriT.TaroraW. and TakahashiH.:Study on Tobacco Components Involved in the Pyrolytic Generation of Selected Smoke Constituents;Food Chem. Toxicol.43(2005)559–568. DOI:10.1016/j.fct.2004.12.011Open DOISearch in Google Scholar
Senneca, O., S. Ciaravolo, and A. Nunziata: Composition of the Gaseous Products of Pyrolysis of Tobacco Under Inert and Oxidative Conditions; J. Anal. Appl. Pyrolysis 79 (2007) 234–243. DOI: 10.1016/j.jaap.2006.09.011SennecaO.CiaravoloS. and NunziataA.:Composition of the Gaseous Products of Pyrolysis of Tobacco Under Inert and Oxidative Conditions;J. Anal. Appl. Pyrolysis79(2007)234–243. DOI:10.1016/j.jaap.2006.09.011Open DOISearch in Google Scholar
Thorne, D., J. Whitwell, J. Clements, P. Walker, D. Breheny, and M. Gaca: The Genotoxicological Assessment of a Tobacco Heating Product Relative to Cigarette Smoke Using the in Vitro Micronucleus Assay; Toxicol. Rep. 7 (2020) 1010–1019. DOI: 10.1016/j.toxrep.2020.08.013ThorneD.WhitwellJ.ClementsJ.WalkerP.BrehenyD. and GacaM.:The Genotoxicological Assessment of a Tobacco Heating Product Relative to Cigarette Smoke Using the in VitroMicronucleus Assay;Toxicol. Rep.7(2020)1010–1019. DOI:10.1016/j.toxrep.2020.08.013Open DOISearch in Google Scholar
Wang, H.J., H. Chen, L. Huang, X.Y. Li, L.L. Wang, S.G. Li, M. Liu, M.Y. Zhang, S.L. Han, X.Y. Jiang, Y.N. Fu, Y.S. Tian, H.W. Hou, and Q.Y. Hu: In Vitro Toxicological Evaluation of a Tobacco Heating Product THP COO and 3R4F Research Reference Cigarette on Human Lung Cancer Cells; Toxicol. in Vitro 74 (2021) 1–12. DOI: 10.1016/j.tiv.2021.105173WangH.J.ChenH.HuangL.LiX.Y.WangL.L.LiS.G.LiuM.ZhangM.Y.HanS.L.JiangX.Y.FuY.N.TianY.S.HouH.W. and HuQ.Y.:In Vitro Toxicological Evaluation of a Tobacco Heating Product THP COO and 3R4F Research Reference Cigarette on Human Lung Cancer Cells;Toxicol. in Vitro74(2021)1–12. DOI:10.1016/j.tiv.2021.105173Open DOISearch in Google Scholar
Jaunky, T., J. Adamson, S. Santopietro, A. Terry, D. Thorne, D. Breheny, C. Proctor, and M. Gaca: Assess-ment of Tobacco Heating Product THP 1.0 Part 5: In Vitro Dosimetric and Cytotoxic Assessment; Regul. Toxicol. Pharmacol. 93 (2018) 52–61. DOI: 10.1016/j.yrtph.2017.09.016JaunkyT.AdamsonJ.SantopietroS.TerryA.ThorneD.BrehenyD.ProctorC. and GacaM.:Assess-ment of Tobacco Heating Product THP 1.0 Part 5: In Vitro Dosimetric and Cytotoxic Assessment;Regul. Toxicol. Pharmacol.93(2018)52–61. DOI:10.1016/j.yrtph.2017.09.016Open DOISearch in Google Scholar
Royal College of Physicians: Nicotine Without Smoke: Tobacco Harm Reduction; London, UK, 2016. Available at: https://www.rcplondon.ac.uk/projects/outputs/nicotine-without-smoke-tobacco-harm-reduction (accessed November 2023)Royal College of Physicians:Nicotine Without Smoke: Tobacco Harm Reduction;London, UK,2016.Available at: https://www.rcplondon.ac.uk/projects/outputs/nicotine-without-smoke-tobacco-harm-reduction(accessed November 2023)Search in Google Scholar
International Organization for Standardization (ISO): ISO 3402:1999 - Tobacco and Tobacco Products — Atmosphere for Conditioning and Testing; ISO, Geneva, Switzerland, 1999.International Organization for Standardization (ISO):ISO 3402:1999 - Tobacco and Tobacco Products — Atmosphere for Conditioning and Testing;ISO,Geneva, Switzerland,1999.Search in Google Scholar
Health Canada: Tobacco Reporting Regulations (SOR/2000-273); Health Canada, Ottawa, ON, Canada, last updated March 13, 2019. Available at: https://laws-lois.justice.gc.ca/eng/regulations/sor-2000-273/index.html (accessed November 2023)Health Canada:Tobacco Reporting Regulations (SOR/2000-273);Health Canada,Ottawa, ON, Canada,last updated March 13, 2019. Available at: https://laws-lois.justice.gc.ca/eng/regulations/sor-2000-273/index.html(accessed November 2023)Search in Google Scholar