<abstract xmlns="http://www.w3.org/1999/xhtml">

Vitamin D regulates not only bone metabolism but also many other processes, including the functioning of lymphocytes. Human T cells have a nuclear receptor for vitamin D (VDR). Studies to date have shown significant seasonal variations in conventional T cell populations in humans living in temperate climates.
<bold>Objectives.</bold> The aim of the current paper was an assessment of seasonal changes of γδ T and iNKT cells in healthy individuals.
<bold>Material and methods.</bold> Peripheral blood was drawn from healthy volunteers – approx. 20 a month – and an additional cohort of 20 volunteers donated blood four times, once every four months. Percentages of γδ T and iNKT cells was assessed with flow cytometry.
<bold>Results.</bold> A pronounced accumulation of iNKT cells was noted in spring, the differences in γδ T cells were less notable. Vitamin D significantly hampers γδ T proliferation <italic>in vitro</italic>. Conclusions. In the presented article, we show seasonal variability within two populations of unconventional T lymphocytes – γδ T and iNKT.
</abstract>

Vitamin D regulates not only bone metabolism but also many other processes, including the functioning of lymphocytes. Human T cells have a nuclear receptor for vitamin D (VDR). Studies to date have shown significant seasonal variations in conventional T cell populations in humans living in temperate climates.
Objectives. The aim of the current paper was an assessment of seasonal changes of γδ T and iNKT cells in healthy individuals.
Material and methods. Peripheral blood was drawn from healthy volunteers – approx. 20 a month – and an additional cohort of 20 volunteers donated blood four times, once every four months. Percentages of γδ T and iNKT cells was assessed with flow cytometry.
Results. A pronounced accumulation of iNKT cells was noted in spring, the differences in γδ T cells were less notable. Vitamin D significantly hampers γδ T proliferation in vitro. Conclusions. In the presented article, we show seasonal variability within two populations of unconventional T lymphocytes – γδ T and iNKT.

Seasonal changes and sex differences in peripheral blood γδ T and iNKT cells in healthy Polish adults

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Vitamin D regulates not only bone metabolism but also many other processes, including the functioning of lymphocytes. Human T cells have a nuclear receptor for...

Seasonal changes and sex differences in peripheral blood γδ T and iNKT cells in healthy Polish adults

Published Online: Jul 10, 2024

Page range: 110 - 113

Received: Jan 25, 2024

Accepted: May 27, 2024

DOI: https://doi.org/10.2478/cipms-2024-0018

Keywords
vitamin D, particulate matter, seasonal changes, iNKT, γδ T

© 2024 Kornelia Karamus et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Seasonal changes and sex differences in peripheral blood γδ T and iNKT cells in healthy Polish adults

Published Online: Jul 10, 2024

Page range: 110 - 113

Received: Jan 25, 2024

Accepted: May 27, 2024

DOI: https://doi.org/10.2478/cipms-2024-0018

Keywordsvitamin D, particulate matter, seasonal changes, iNKT, γδ T

© 2024 Kornelia Karamus et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
vitamin D, particulate matter, seasonal changes, iNKT, γδ T