<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Eight drugs blocking beta-adrenergic receptors activity (acebutolol, alprenolol, atenolol, oxprenolol, labetalol, metoprolol, propranolol and sotalol) were investigated through the use of the thin-layer technique with its mobile phase containing surfactant. Assessment of the effect of surfactant presence and 1-propanol concentration in the mobile phase on the retention and separation of investigated solutes was then carried out wherein the effect of the surfactant concentration on the zone shape properties (asymmetry and tailing coefficient) was investigated. The method was applied for the quantitative analysis of the chosen solutes, and the LOD and LOQ values of chosen were determined. These were as follows: acebutolol – 1.11 and 3.36 μg/spot, metoprolol 1.45 μg/spot, 4.4 μg/spot. The chosen system is environmentally friendly due to using silica gel plates and only 5% of propanol in water.</p>
</abstract>

Eight drugs blocking beta-adrenergic receptors activity (acebutolol, alprenolol, atenolol, oxprenolol, labetalol, metoprolol, propranolol and sotalol) were investigated through the use of the thin-layer technique with its mobile phase containing surfactant. Assessment of the effect of surfactant presence and 1-propanol concentration in the mobile phase on the retention and separation of investigated solutes was then carried out wherein the effect of the surfactant concentration on the zone shape properties (asymmetry and tailing coefficient) was investigated. The method was applied for the quantitative analysis of the chosen solutes, and the LOD and LOQ values of chosen were determined. These were as follows: acebutolol – 1.11 and 3.36 μg/spot, metoprolol 1.45 μg/spot, 4.4 μg/spot. The chosen system is environmentally friendly due to using silica gel plates and only 5% of propanol in water.

Determination of β-blocking receptor drugs in silica gel TLC systems with the mobile phase containing surfactant

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Eight drugs blocking beta-adrenergic receptors activity (acebutolol, alprenolol, atenolol, oxprenolol, labetalol, metoprolol, propranolol and sotalol) were...

Determination of β-blocking receptor drugs in silica gel TLC systems with the mobile phase containing surfactant

Published Online: Feb 09, 2023

Page range: 212 - 218

Received: Jul 29, 2022

Accepted: Dec 19, 2022

DOI: https://doi.org/10.2478/cipms-2022-0037

Keywords
β-blocking receptor drug, TLC analysis, micellar system, sodium cholate.

© 2022 Adam Traczuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Determination of β-blocking receptor drugs in silica gel TLC systems with the mobile phase containing surfactant

Published Online: Feb 09, 2023

Page range: 212 - 218

Received: Jul 29, 2022

Accepted: Dec 19, 2022

DOI: https://doi.org/10.2478/cipms-2022-0037

Keywordsβ-blocking receptor drug, TLC analysis, micellar system, sodium cholate.

© 2022 Adam Traczuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
β-blocking receptor drug, TLC analysis, micellar system, sodium cholate.