Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)

1. World Health Organization (WHO). Indonesia Fact Sheets. International Agency for Research on Cancer; 2012. Search in Google Scholar

2. de Camargo Cancela M, Voti L, Guerra-Yi M, Chapuis F, Mazuir M, Curado MP. Oral cavity cancer in developed and in developing countries: Population-based incidence. J Sci Spec Head Neck. 2009. https://doi.org/10.1002/hed.2119310.1002/hed.2119319644932 Search in Google Scholar

3. Kardeh S, Ashkani-Esfahani S, Alizadeh AM. Paradoxical action of reactive oxygen species in creation and therapy of cancer. Eur J Pharmacol. 2014;735:150-68.10.1016/j.ejphar.2014.04.02324780648 Search in Google Scholar

4. Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Ind J Clin Biochem. 2015;30(1):11-26.10.1007/s12291-014-0446-0431083725646037 Search in Google Scholar

5. Oladeji OS, Adelowo FE, Ayodele DT, Odelade KA. Phytochemistry and pharmacological activities of Cymbopogon citratus: A review. Sci Af. 2019;6:e00137.10.1016/j.sciaf.2019.e00137 Search in Google Scholar

6. Komariah A, A Tatara R, A Bustami D. Efficacy of Rhinoceros Beetle (Xylotrupes gideon) nano chitosan and calcium mouthwash in reducing quantity oral cavity bacteria among elementary school age children. Int J Adv Biol Biom Res. 2017;05(01):41-5. Search in Google Scholar

7. Denoth-Lippuner A, Jaeger BN, Liang T, Chie SE, Royall N, Kruse M, et al. Visualization of individual cell division history in complex tissues. bioRxiv: https://doi.org/10.1101/2020.08.26.26617110.1101/2020.08.26.266171 Search in Google Scholar

8. Rizeq BR, Younes NN, Rasool K, Nasrallah GK. Synthesis, bioapplications, and toxicity evaluation of chitosan-based nanoparticles. IJMS. 2019;20(22):5776.10.3390/ijms20225776688809831744157 Search in Google Scholar

9. Aggarwal V, Tuli H, Varol A, Thakral F, Yerer M, Sak K, et al. Role of reactive oxygen species in cancer progression: Molecular mechanisms and recent advancements. Biomolecules. 2019;9(11):735.10.3390/biom9110735692077031766246 Search in Google Scholar

10. Reczek CR, Chandel NS. ROS promotes cancer cell survival through calcium signaling. Cancer Cell. 2018;33(6):949-51.10.1016/j.ccell.2018.05.01029894695 Search in Google Scholar

11. Ivanova DG, Yaneva ZL. Antioxidant properties and redox-modulating activity of chitosan and its derivatives: Biomaterials with application in cancer therapy. BioResearch Open Access. 2020;9. https://doi.org/10.1089/biores.2019.002810.1089/biores.2019.0028709768332219012 Search in Google Scholar

12. Hernández-Espinosa DR, Massieu L, Montiel T, Morán J. Role of NADPH oxidase-2 in the progression of the inflammatory response secondary to striatum excitotoxic damage. J Neuroinflammation. 2019;16(1):91.10.1186/s12974-019-1478-4647179530995916 Search in Google Scholar

13. Martinez-Perez C, Ward C, Cook G, Mullen P, McPhail D, Harrison DJ, et al. Novel flavonoids as anti-cancer agents: mechanisms of action and promise for their potential application in breast cancer. Biochem Soc Trans. 2014;42(4):1017-23.10.1042/BST2014007325109996 Search in Google Scholar

14. Jiang Y, Yu X, Su C, Zhao L, Shi Y. Chitosan nanoparticles induced the antitumor effect in hepatocellular carcinoma cells by regulating ROS-mediated mitochondrial damage and endoplasmic reticulum stress. Artif Cells Nanomed Biotechnol. 2019;47(1):747-56.10.1080/21691401.2019.157787630873872 Search in Google Scholar

15. Philion C, Ma D, Ruvinov I, Mansour F, Pignanelli C, Noel M, et al. Cymbopogon citratus and Camellia sinensis extracts selectively induce apoptosis in cancer cells and reduce growth of lymphoma xenografts in vivo. Oncotarget. 2017;8(67):110756-73.10.18632/oncotarget.22502576228229340014 Search in Google Scholar

16. Tofiño-Rivera AP, Castro-Amaris G, Casierra-Posada F. Effectiveness of cymbopogon citratus oil encapsulated in chitosan on colletotrichum gloeosporioides isolated from capsicum annuum. Molecules. 2020;25(19):4447.10.3390/molecules25194447758235532998189 Search in Google Scholar

17. Madi YF, Choucry MA, El-Marasy SA, Meselhy MR, El-Kashoury E-SA. UPLC-Orbitrap HRMS metabolic profiling of Cymbopogon citratus cultivated in Egypt; neuroprotective effect against AlCl3-induced neurotoxicity in rats. J Ethnopharmacol. 2020;259:112930.10.1016/j.jep.2020.11293032376365 Search in Google Scholar