Study on in vitro Toxicity of Biometal(II) Monensinates Against Rat Zajdela Liver Tumour

The ability of Monensic acid A (MonH∙H₂O) and its neutral metal complexes [M(Mon)₂(H₂O)₂]with ions of Mg²⁺, Ca²⁺, Mn²⁺, Co²⁺, Ni²⁺ and Zn²⁺ to decrease viability and proliferation of primary cell cultures, originating from a chemically induced transplantable liver tumour of Zajdela in rats, and bone marrow cells from the same tumour-bearers, was evaluated. Experimental data revealed that manganese(II) and nickel(II) complexes of Monensin A are relatively more selective against the tumour as compared to the healthy bone marrow cells.