<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by the interaction of genetic and non-genetic factors. Therefore, the aim of our study was to investigate the association between six common genetic polymorphisms and T2DM and MetS in males. A total of 120 T2DM, 75 MetS, and 120 healthy controls (HC) were included in the study. <italic>ACE</italic> ID, <italic>eNOS</italic> 4a/b, <italic>ATR1</italic> A1166C, <italic>OXTR</italic> (A>G), <italic>SOD1</italic> +35A/C, <italic>CAT</italic>-21A/T gene polymorphisms were genotyped by PCR or PCR-RFLP techniques. T2DM was diagnosed at an earlier age compared to MetS (54 vs 55 years old, p=0.0003) and the difference was greater in carriers of the <italic>OXTR</italic> G allele (54 vs 56 years old, p=0.0002) or both <italic>OXTR</italic> G and <italic>eNOS</italic> b alleles (54 vs 56, p=0.00016). The <italic>SOD1</italic> AA genotype (O.R.=0.11, p=0.0006) and the presence of both <italic>ACE</italic> I and <italic>OXTR1</italic> A (O.R.=0.39, p=0.0005) alleles revealed to be protective for T2DM. <italic>SOD1</italic> AA and AC genotypes were protective factors for triglyceride (p=0.0002 and p=0.0005, respectively) and HDL cholesterol (p=0.0002 and p=0.0004, respectively) levels in T2DM patients. <italic>ACE</italic> DD was identified more frequently in hypertensive T2DM patients (O.R.=3.77, p=0.0005) and in those who reported drinking alcohol (p=0.0001) comparing to HC and T2DM patients who did not drink alcohol, respectively. We observed that T2DM patients who reported drinking alcohol had an increased frequency of <italic>ACE</italic> DD and <italic>eNOS</italic> bb (p&lt;0.0001), or <italic>ACE</italic> DD and <italic>OXTR</italic> G (p&lt;0.0001) compared to non-drinkers. No gene polymorphisms were associated with MetS.</p>
</abstract>

Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by the interaction of genetic and non-genetic factors. Therefore, the aim of our study was to investigate the association between six common genetic polymorphisms and T2DM and MetS in males. A total of 120 T2DM, 75 MetS, and 120 healthy controls (HC) were included in the study. ACE ID, eNOS 4a/b, ATR1 A1166C, OXTR (A>G), SOD1 +35A/C, CAT-21A/T gene polymorphisms were genotyped by PCR or PCR-RFLP techniques. T2DM was diagnosed at an earlier age compared to MetS (54 vs 55 years old, p=0.0003) and the difference was greater in carriers of the OXTR G allele (54 vs 56 years old, p=0.0002) or both OXTR G and eNOS b alleles (54 vs 56, p=0.00016). The SOD1 AA genotype (O.R.=0.11, p=0.0006) and the presence of both ACE I and OXTR1 A (O.R.=0.39, p=0.0005) alleles revealed to be protective for T2DM. SOD1 AA and AC genotypes were protective factors for triglyceride (p=0.0002 and p=0.0005, respectively) and HDL cholesterol (p=0.0002 and p=0.0004, respectively) levels in T2DM patients. ACE DD was identified more frequently in hypertensive T2DM patients (O.R.=3.77, p=0.0005) and in those who reported drinking alcohol (p=0.0001) comparing to HC and T2DM patients who did not drink alcohol, respectively. We observed that T2DM patients who reported drinking alcohol had an increased frequency of ACE DD and eNOS bb (p<0.0001), or ACE DD and OXTR G (p<0.0001) compared to non-drinkers. No gene polymorphisms were associated with MetS.

The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome

University of Medicine and Pharmacy Carol Davila

Balkan Journal of Medical Genetics

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome"}

Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by the interaction of genetic and non-genetic factors. Therefore, the aim of...

The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome

Article Category: Original Article

Published Online: Jul 31, 2023

Page range: 21 - 26

DOI: https://doi.org/10.2478/bjmg-2023-0003

Keywords
ID, VNTR 4a/b, metabolic syndrome, (A>G), +35A/C, type 2 diabetes mellitus

© 2023 C Zenoaga-Barbăroșie et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome

Article Category: Original Article

Published Online: Jul 31, 2023

Page range: 21 - 26

DOI: https://doi.org/10.2478/bjmg-2023-0003

KeywordsID, VNTR 4a/b, metabolic syndrome, (A>G), +35A/C, type 2 diabetes mellitus

© 2023 C Zenoaga-Barbăroșie et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
ID, VNTR 4a/b, metabolic syndrome, (A>G), +35A/C, type 2 diabetes mellitus