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The aim of this work was to investigate the effect of processing parameters of the electrospinning method on the resulting poly (vinylidene fluoride) (PVDF) fiber diameter. A three factorial Box-Behnken experimental design was employed to study the influence of applied voltage, the capillary-to-collector distance and the applied flow rate on the resulting fiber diameter. We successfully prepared bead-free PVDF nanofibers with fiber diameters ranging from 510-1300 nm. The experimental design analysis did not show significant influence of the studied process parameters under the used boundary conditions on the fiber diameter, thus indicating the robustness of the process.