<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1<italic>H</italic>)-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and thiourea. These thione derivatives were characterized by their analytical, physical, and spectroscopic data. In addition, the <italic>in vitro</italic> antibacterial activities of these pyrimidine derivatives were evaluated using Bauer-Kirby disc diffusion method.</p>
</abstract>

The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1H)-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and thiourea. These thione derivatives were characterized by their analytical, physical, and spectroscopic data. In addition, the in vitro antibacterial activities of these pyrimidine derivatives were evaluated using Bauer-Kirby disc diffusion method.

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1<italic>H</italic>)-thiones

Ovidius University Annals of Chemistry

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1)-thiones

The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1H)-thione compounds using sodium hydroxide...

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones

Published Online: Jun 07, 2024

Page range: 36 - 42

Received: Aug 04, 2023

Accepted: Apr 20, 2024

DOI: https://doi.org/10.2478/auoc-2024-0005

Keywords
pyrimidinethiones, acetonaphthones, thiourea, NMR spectra, antibacterial activity

© 2024 Rajendran Venkatraman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones

Published Online: Jun 07, 2024

Page range: 36 - 42

Received: Aug 04, 2023

Accepted: Apr 20, 2024

DOI: https://doi.org/10.2478/auoc-2024-0005

Keywordspyrimidinethiones, acetonaphthones, thiourea, NMR spectra, antibacterial activity

© 2024 Rajendran Venkatraman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
pyrimidinethiones, acetonaphthones, thiourea, NMR spectra, antibacterial activity