Particularities of Experimental Models Used to Induce Gastric Ulcer

1. Rau W, Hohaus C, Jessen E. A Differential Approach to Form and Site of Peptic Ulcer. Sci Rep. 2019 Jun 18;9(1):8683.10.1038/s41598-019-44893-xSearch in Google Scholar

2. Ernst H, Konturek PC, Brzozowski T, Lochs H, Hahn EG, Konturek SJ. Adaptation of gastric mucosa to stress. Effect of ranitidine. J Physiol Pharmacol. 1998 Sep;49(3):405-19.Search in Google Scholar

3. Guo S, Gao Q, Jiao Q, Hao W, Gao X, Cao JM. Gastric mucosal damage in water immersion stress: mechanism and prevention with GHRP-6. World J Gastroenterol. 2012 Jun 28;18(24):3145-55.10.3748/wjg.v18.i24.3145Search in Google Scholar

4. Rainsford KD. The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice. Agents Actions. 1987 Aug;21(3-4):316-9.10.1007/BF01966502Search in Google Scholar

5. Nur Azlina M.F., Qodriyah H., Chua K.H., & Kamisah Y. (2017). Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats. World J Gastroenterol. 23(32):5887–5894.10.3748/wjg.v23.i32.5887Search in Google Scholar

6. Somasundaram S, Rafi S, Hayllar J, Sigthorsson G, Jacob M, Price AB, et al. Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID induced injury to the rat intestine. Gut. 1997 Sep;41(3):344-53.10.1136/gut.41.3.344Search in Google Scholar

7. Chen XY, Chen HM, Liu YH, Zhang ZB, Zheng YF, Su ZQ, et al. The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. Exp Biol Med (Maywood). 2016 Jan;241(2):193-204.10.1177/1535370215600099Search in Google Scholar

8. Urushidani T, Kasuya Y, Okabe S. The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat. Jpn J Pharmacol. 1979 Oct;29(5):775-80.10.1016/S0021-5198(19)31510-0Search in Google Scholar

9. Nazarbahjat N, Kadir FA, Ariffin A, Abdulla MA, Abdullah Z, Yehye WA. Antioxidant Properties and Gastroprotective Effects of 2-(Ethylthio)Benzohydrazones on Ethanol-Induced Acute Gastric Mucosal Lesions in Rats. PLoS One. 2016;11(6):e0156022.10.1371/journal.pone.0156022489644227272221Search in Google Scholar

10. Ibrahim MY, Hashim NM, Dhiyaaldeen SM, Al-Obaidi MM, El-Ferjani RM, Adam H, et al. Acute Toxicity and Gastroprotection Studies of a New Schiff Base Derived Manganese (II) Complex against HCl/Ethanol-Induced Gastric Ulcerations in Rats. Sci Rep. 2016 May 27;6:26819.10.1038/srep26819488252027229938Search in Google Scholar

11. Warzecha Z, Dembinski A, Brzozowski T, Ceranowicz P, Dembinski M, Stachura J, et al. Histamine in stress ulcer prophylaxis in rats. J Physiol Pharmacol. 2001 Sep;52(3):407-21.Search in Google Scholar

12. Baumeister A.A., Hawkins M.F. and Uzelac S.M.( 2003): The myth of reserpineinduced depression: role in the historical development of the monoamine hypothesis. J Hist Neurosci 12: 207220.10.1076/jhin.12.2.207.1553512953623Search in Google Scholar

13. Cheng YT, Lu CC, Yen GC. Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa. Mol Nutr Food Res. 2017 Jun;61(6).10.1002/mnfr.20160065927883262Search in Google Scholar

14. Perez S, Talens-Visconti R, Rius-Perez S, Finamor I, Sastre J. Redox signaling in the gastrointestinal tract. Free Radic Biol Med. 2017 Mar;104:75-103.10.1016/j.freeradbiomed.2016.12.048Search in Google Scholar

15. Oka S, Ogino K, Hobara T, Yoshimura S, Yanai H, Okazaki Y, et al. Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat. Experientia. 1990 Mar 15;46(3):281-310.1007/BF01951766Search in Google Scholar

16. Shah DI, Santani DD, Goswami SS. A novel use of methylene blue as a pharmacological tool. J Pharmacol Toxicol Methods. 2006 Nov-Dec;54(3):273-7.10.1016/j.vascn.2005.12.003Search in Google Scholar

17. Naito Y, Yoshikawa T, Yoneta T, Yagi N, Matsuyama K, Arai M, et al. A new gastric ulcer model in rats produced by ferrous iron and ascorbic acid injection. Digestion. 1995;56(6):472-8.10.1159/000201278Search in Google Scholar

18. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology. 1945; 5:43-61.Search in Google Scholar

19. Wada K, Kamisaki Y, Kitano M, Kishimoto Y, Nakamoto K, Itoh T. A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach. Life Sci. 1996;59(19):PL295-301.10.1016/0024-3205(96)00500-0Search in Google Scholar

20. Fu Y, Wu HQ, Cui HL, Li YY, Li CZ. Gastroprotective and anti-ulcer effects of oxymatrine against several gastric ulcer models in rats: Possible roles of antioxidant, antiinflammatory, and prosurvival mechanisms. Phytother Res. 2018 Oct;32(10):2047-58.10.1002/ptr.614830024074Search in Google Scholar

21. Adinortey MB, Ansah C, Galyuon I, Nyarko A. In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents. Ulcers. 2013;2013:12.10.1155/2013/796405Search in Google Scholar

22. Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N. Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-alpha, NF-kB, and COX-2 levels, and upregulation of TFF-2 levels. Biomed Pharmacother. 2019 Feb;110:554-60.10.1016/j.biopha.2018.12.00230530291Search in Google Scholar

23. Piao X, Li S, Sui X, Guo L, Liu X, Li H, et al. 1-Deoxynojirimycin (DNJ) Ameliorates Indomethacin-Induced Gastric Ulcer in Mice by Affecting NF-kappa B Signaling Pathway. Front Pharmacol. 2018;9:372-9.10.3389/fphar.2018.00372591744829725297Search in Google Scholar