<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The current study assessed the benefits of marjoram essential oil (MEO) in reducing the aflatoxin B1 (AFB1) toxicity in growing rabbits. Forty-eight rabbits, aged 4 weeks, were randomly assigned to four groups (4 replications of 3 rabbits/replicate) as follows: BD group (control); AFB1 group (supplemented with AFB1 0.3 mg/kg diet); MEO-supplemented group (1 g MEO/kg diet); AFB1 + MEO group (AFB1 0.3 mg/kg diet + 1 g MEO/kg diet). AFB1 exposure resulted in reduction of rabbit growth and total protein and albumin content in serum; increased liver function related enzymes (ALP, ALT and AST); induced oxidative stress displayed by lower level of antioxidant enzymes (CAT and GSH), increased biomarkers of DNA and lipid oxidative damage with significant upregulation of the tumor suppressor protein interferon-γ, interleukin 1β, tumor necrosis factor-α and heat shock protein-70 when compared to the control (P&lt;0.05). Moreover, exposure to AFB1 increased the bioaccumulation of AFB1 residues in rabbit liver. Supplementation of MEO in the AFB1-exposed rabbits alleviated all of its negative effects. In conclusion, dietary addition of 1 g MEO could effectively ameliorate the adverse impacts of AFB1 on rabbit growth; enhanced their antioxidants and reduced oxidative stress and inflammatory response indicators, as well as the AFB1 residues in liver.</p>
</abstract>

The current study assessed the benefits of marjoram essential oil (MEO) in reducing the aflatoxin B1 (AFB1) toxicity in growing rabbits. Forty-eight rabbits, aged 4 weeks, were randomly assigned to four groups (4 replications of 3 rabbits/replicate) as follows: BD group (control); AFB1 group (supplemented with AFB1 0.3 mg/kg diet); MEO-supplemented group (1 g MEO/kg diet); AFB1 + MEO group (AFB1 0.3 mg/kg diet + 1 g MEO/kg diet). AFB1 exposure resulted in reduction of rabbit growth and total protein and albumin content in serum; increased liver function related enzymes (ALP, ALT and AST); induced oxidative stress displayed by lower level of antioxidant enzymes (CAT and GSH), increased biomarkers of DNA and lipid oxidative damage with significant upregulation of the tumor suppressor protein interferon-γ, interleukin 1β, tumor necrosis factor-α and heat shock protein-70 when compared to the control (P<0.05). Moreover, exposure to AFB1 increased the bioaccumulation of AFB1 residues in rabbit liver. Supplementation of MEO in the AFB1-exposed rabbits alleviated all of its negative effects. In conclusion, dietary addition of 1 g MEO could effectively ameliorate the adverse impacts of AFB1 on rabbit growth; enhanced their antioxidants and reduced oxidative stress and inflammatory response indicators, as well as the AFB1 residues in liver.

<italic>Origanum majorana</italic> Essential Oil Ameliorated the Behavioral, Biochemical, Physiological and Performance Perturbations Induced by Aflatoxin B1 in Growing Rabbits

Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine

Behaviour and Management of Animal, Poultry and Aquatics Department, Faculty of Veterinary Medicine

Nutrition and Veterinary Clinical Nutrition Department, Faculty of Veterinary Medicine

Department of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine

Department of Animal and Poultry production, Faculty of Agriculture

Poultry Department, Faculty of Agriculture

Anatomy and Embryology Department, Faculty of Veterinary Medicine

Annals of Animal Science

This work is licensed under the Creative Commons Attribution 4.0 International License.

 Essential Oil Ameliorated the Behavioral, Biochemical, Physiological and Performance Perturbations Induced by Aflatoxin B1 in Growing Rabbits

The current study assessed the benefits of marjoram essential oil (MEO) in reducing the aflatoxin B1 (AFB1) toxicity in growing rabbits. Forty-eight rabbits,...

Origanum majorana Essential Oil Ameliorated the Behavioral, Biochemical, Physiological and Performance Perturbations Induced by Aflatoxin B1 in Growing Rabbits

Published Online: Nov 13, 2023

Page range: 1201 - 1210

Received: Jan 22, 2023

Accepted: Apr 03, 2023

DOI: https://doi.org/10.2478/aoas-2023-0035

Keywords
aflatoxins, marjoram, rabbit, growth, behavior, antioxidant, liver

© 2023 Mayada R. Farag et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Origanum majorana Essential Oil Ameliorated the Behavioral, Biochemical, Physiological and Performance Perturbations Induced by Aflatoxin B1 in Growing Rabbits

Published Online: Nov 13, 2023

Page range: 1201 - 1210

Received: Jan 22, 2023

Accepted: Apr 03, 2023

DOI: https://doi.org/10.2478/aoas-2023-0035

Keywordsaflatoxins, marjoram, rabbit, growth, behavior, antioxidant, liver

© 2023 Mayada R. Farag et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
aflatoxins, marjoram, rabbit, growth, behavior, antioxidant, liver