<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The present study was performed to determine the effect of melatonin on cadmium accumulation and haematological parameters changes in females of Prussian carp (<italic>Carassius gibelio</italic> B.). The fish were exposed to a sublethal concentration of cadmium (0.4 and 4.0 mg/L) without or with melatonin implant (containing 18 mg melatonin hormone) for 1, 4, 7, 10 and 13 weeks. After the 7th week, Cd-exposed fish were divided into two groups. The first group of fish were subjected to depuration in clear water, while the second group remained exposed to the same concentrations of cadmium. After the 10th and 13th weeks of exposure the kidney, spleen, heart and blood were taken in order to determine the cadmium concentration and to analyse haematological parameters. The results of this study showed an increase in the concentration of cadmium in the tissues and blood in fish exposed to the highest dose (4.0 mg/L) of cadmium in water with a dependence on the exposure duration. Additionally, it was shown that melatonin administration reduced the cadmium concentration in the tissues and blood, and melatonin had a protective effect against cadmium accumulation. Moreover, the results showed a significant increase in blood parameters (RBC, Ht and Hb) in fish treated with the highest dose of cadmium. However, implantation of melatonin in cadmium-treated fish resulted in marked improvements in haematological parameters. Thus, melatonin can be a good implementation to alleviate, at least partially, the toxicity of cadmium.</p>
</abstract>

The present study was performed to determine the effect of melatonin on cadmium accumulation and haematological parameters changes in females of Prussian carp (Carassius gibelio B.). The fish were exposed to a sublethal concentration of cadmium (0.4 and 4.0 mg/L) without or with melatonin implant (containing 18 mg melatonin hormone) for 1, 4, 7, 10 and 13 weeks. After the 7th week, Cd-exposed fish were divided into two groups. The first group of fish were subjected to depuration in clear water, while the second group remained exposed to the same concentrations of cadmium. After the 10th and 13th weeks of exposure the kidney, spleen, heart and blood were taken in order to determine the cadmium concentration and to analyse haematological parameters. The results of this study showed an increase in the concentration of cadmium in the tissues and blood in fish exposed to the highest dose (4.0 mg/L) of cadmium in water with a dependence on the exposure duration. Additionally, it was shown that melatonin administration reduced the cadmium concentration in the tissues and blood, and melatonin had a protective effect against cadmium accumulation. Moreover, the results showed a significant increase in blood parameters (RBC, Ht and Hb) in fish treated with the highest dose of cadmium. However, implantation of melatonin in cadmium-treated fish resulted in marked improvements in haematological parameters. Thus, melatonin can be a good implementation to alleviate, at least partially, the toxicity of cadmium.

Effects of Melatonin on Cadmium Accumulation and Haematological Parameters in Cadmium Intoxicated Prussian Carp (<italic>Carassius gibelio</italic> B.)

Department of Animal Nutrition and Biotechnology, and Fisheries

Department of Animal Physiology and Endocrinology

Annals of Animal Science

This work is licensed under the Creative Commons Attribution 4.0 International License.

Effects of Melatonin on Cadmium Accumulation and Haematological Parameters in Cadmium Intoxicated Prussian Carp ( B.)

The present study was performed to determine the effect of melatonin on cadmium accumulation and haematological parameters changes in females of Prussian carp...

Effects of Melatonin on Cadmium Accumulation and Haematological Parameters in Cadmium Intoxicated Prussian Carp (Carassius gibelio B.)

Published Online: Aug 05, 2021

Page range: 899 - 923

Received: Feb 06, 2020

Accepted: May 15, 2020

DOI: https://doi.org/10.2478/aoas-2020-0105

Keywords
cadmium, Prussian carp, haematological parameters, accumulation, depuration

© 2021 Ewa Drąg-Kozak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Effects of Melatonin on Cadmium Accumulation and Haematological Parameters in Cadmium Intoxicated Prussian Carp (Carassius gibelio B.)

Published Online: Aug 05, 2021

Page range: 899 - 923

Received: Feb 06, 2020

Accepted: May 15, 2020

DOI: https://doi.org/10.2478/aoas-2020-0105

Keywordscadmium, Prussian carp, haematological parameters, accumulation, depuration

© 2021 Ewa Drąg-Kozak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
cadmium, Prussian carp, haematological parameters, accumulation, depuration