1. bookVolume 19 (2019): Issue 1 (January 2019)
Journal Details
License
Format
Journal
eISSN
2300-8733
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
access type Open Access

Redox and Immunological Status of Turkeys Fed Diets with Different Levels and Sources of Copper

Published Online: 01 Feb 2019
Volume & Issue: Volume 19 (2019) - Issue 1 (January 2019)
Page range: 215 - 227
Received: 09 Jul 2018
Accepted: 20 Nov 2018
Journal Details
License
Format
Journal
eISSN
2300-8733
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
Abstract

This study, performed on turkeys aged 1 to 98 days, aimed to investigate whether different dietary inclusion levels (20, 10, 2 mg kg−1) of copper nanoparticles (Cu-NP) as a substitute for copper sulphate (Cu-SUL) affect redox and immunological status of turkeys’ tissues. No significant differences in the final body weights of turkeys were found across the dietary treatments. A comparison of the physiological effects of Cu-NP and Cu-SUL revealed equivocal metabolic responses including decreased superoxide dismutase (SOD) activity in the liver, increased SOD and catalase activities in breast muscles, decreased total glutathione concentrations in breast muscles, and decreased plasma IgY concentrations. An analysis of the antioxidant and immune status parameters in the blood, liver and breast meat of turkeys indicates that 10 mg/kg is the optimal inclusion level of additional Cu. Both two-fold higher and five-fold lower Cu supplementation levels have a negative influence on selected parameters of the antioxidant and immune status of birds. Lower supplementation levels of Cu-NP (2 and 10 mg/kg) exert similar physiological effects to Cu-SUL, whereas higher addition of Cu-NP (20 mg/kg) may negatively affect selected redox parameters and stimulate the synthesis of the proinflammatory cytokine IL-6. The results of the present study indicate that further research is needed to establish the actual dietary requirements for Cu in turkeys and the efficacy of nanoparticles as a new additional Cu source in turkey nutrition.

Keywords

Ajuwon O.R., Idowu O.M.O., Afolabi S.A., Kehinde B.O., Oguntola O.O., Olatun-bosun K.O. (2011). The effects of dietary copper supplementation on oxidative and antioxidant systems in broiler chickens. Arch. Zootec., 60: 275–282.Search in Google Scholar

Albanese A., Tang P.S., Chan W.C.W. (2012). The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu. Rev. Biomed. Eng., 14: 1–16.Search in Google Scholar

Amstad P., Moret R., Cerutti P. (1994). Glutathione peroxidase compensates for the hypersensitivity of Cu, Zn-superoxide dismutase overproducers to oxidant stress. J. Biol. Chem., 269: 1606–1609.Search in Google Scholar

Bao Y.M., Choct M., Iji P., Bruerton A. (2007). Effect of organically complexed copper, iron, manganese and zinc on broiler performance, mineral excretion and accumulation in tissues. J. Appl. Poultry Res., 16: 448–455.Search in Google Scholar

Bunglavan S.J., Dass A.K.G., Shrivastava S. (2014). Use of nanoparticles as feed additives to improve digestion and absorption in livestock. Livestock Res. Int., 2: 36–47.Search in Google Scholar

Dinant H.J., Dijkmans B.A.C. (1999). New therapeutic targets for rheumatoid arthritis. Pharm. World Sci., 21: 49–59.Search in Google Scholar

EFSA, Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). (2016). Revision of the currently authorised maximum copper content in complete feed. EFSA J., 14: 4563.Search in Google Scholar

El Sabry M.I., Mc Millin K.W., Sabliov C.M. (2018). Nanotechnology considerations for poultry and livestock production systems – a review. Ann. Anim. Sci., 18: 319–334.Search in Google Scholar

Freedman J.H., Wolterbeek H.T. (1989). The role of glutathione in copper metabolism and toxicity. J. Biol. Chem., 264: 5590–5605.Search in Google Scholar

Hill E.K., Li J. (2017). Current and future prospects for nanotechnology in animal production. J. Anim. Sci. Biotechnol., 8: 26.Search in Google Scholar

Hussain N., Jaitley V., Florence A.T. (2001). Recent advances in the understanding of uptake of microparticles across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev., 50: 107–142.Search in Google Scholar

Hybrid Turkeys (2013). Nutrient Guidelines. http://resources.hybridturkeys.com/nutrition/commercial-guidelines (accessed 09.07.2018).Search in Google Scholar

Kim J.W., Chao P.Y., Allen A. (1992). Inhibition of elevated hepatic glutathione abolishes copper deficiency cholesterolemia. FASEB J., 6: 2467–2471.Search in Google Scholar

Klasing K.C. (1998). Nutritional modulation of resistance to infectious diseases. Poultry Sci., 77: 1119–1125.Search in Google Scholar

Maheshwari S. (2013). Environmental impacts of poultry production. Poult. Fish Wildl. Sci., 1: 101–103.Search in Google Scholar

Majewski M., Ognik K., Zduńczyk P., Juśkiewicz J. (2017). Effect of dietary copper nanoparticles versus one copper (II) salt: analysis of vasoreactivity in a rat model. Pharmacol. Rep., 69: 1282–1288.Search in Google Scholar

Makarski B., Gortat M., Lechowski J.,Żukiewicz-Sobczak W., Sobczak P., Zawiślak K. (2014). Impact of copper (Cu) at the dose of 50 mg on haematological and biochemical blood parameters in turkeys, and level of Cu accumulation in the selected tissues as a source of information on product safety for consumers. Ann. Agric. Environ. Med., 21: 567–570.Search in Google Scholar

Malavolta M., Piacenza F., Basso A., Giacconi R., Costarelli L., Mocchegia-ni E. (2015). Serum copper to zinc ratio: relationship with aging and health status. Mech. Ageing. Dev., 151: 93–100.Search in Google Scholar

Mc Cord J.M. (1983). The superoxide free radical: its biochemistry and pathophysiology. Surgery, 94: 412–414.Search in Google Scholar

Mikulski D., Jankowski J., Zduńczyk Z., Wróblewska M., Mikulska M. (2009). Copper balance, bone mineralization and the growth performance of turkeys fed diet with two types of Cu supplements. J. Anim. Feed Sci., 18: 677–688.Search in Google Scholar

Nollet L., Huyghebaert G., Spring P. (2008). Effect of different levels of dietary organic (Biolpex) trace minerals on live performance of broiler chickens by growth phases. J. Appl. Poultry Res., 17: 109–115.Search in Google Scholar

NRC (1994). Nutrient Requirements of Poultry. 9th rev. ed. Natl. Acad. Press, Washington, DC.Search in Google Scholar

Ognik K., Wertelecki T. (2012). Effect of different vitamin E sources and levels on selected oxidative status indices in blood and tissues as well as on rearing performance of slaughter turkey hens. J. Appl. Poultry Res., 2: 259–271.Search in Google Scholar

Ognik K., Stępniowska A., Cholewińska E., Kozłowski K. (2016). The effect of administration of copper nanoparticles to chickens in drinking water on estimated intestinal absorption of iron, zinc, and calcium. Poultry Sci., 95: 2045–2051.Search in Google Scholar

Percival S.S. (1998). Copper and immunity. Am. J. Clin. Nutr., 67: 1064S–1068S.Search in Google Scholar

Samanta B., Ghosh P.R., Biswas A., Das S.K. (2011). The effects of copper supplementation on the performance and hematological parameters of broiler chickens. Asian-Australas. J. Anim. Sci., 24: 1001–1006.Search in Google Scholar

Smulikowska S., Rutkowski A. (2005). Recommended Allowances and Nutritive Value of Feedstuffs – Poultry Feeding Standards (in Polish). 5th ed. Smulikowska, S., Rutkowski, A., Eds. The Kielanowski Institute of Animal Physiology and Nutrition, Jablonna, PAS, Poland.Search in Google Scholar

Sunderman Jr F.W., Nomoto S. (1970). Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity. Clin. Chem., 16: 903–910.Search in Google Scholar

Tomaszewska E., Muszyński S., Ognik K., Dobrowolski P., Kwiecień M., Juśkiewicz J., Chocyk D., Świetlicki M., Blicharski T., Gładyszewska B. (2017). Comparison of the effect of dietary copper nanoparticles with copper (II) salt on bone geometric and structural parameters as well as material characteristics in a rat model. J. Trace Elem. Med. Biol., 42: 103–110.Search in Google Scholar

Wang C., Wang M.Q., Ye S.S., Tao W.J., Du Y.J. (2011). Effects of copper-loaded chitosan nanoparticles on growth and immunity in broilers. Poultry Sci., 90: 2223–2228.Search in Google Scholar

Xiang-Qi Z., Zhang K.-Y., Ding X.-M., Bai S.-P. (2009). Effects of dietary supplementation with copper sulfate or tribasic copper chloride on carcass characteristics, tissular nutrients deposition and oxidation in broilers. Pakistan J. Nutr., 8: 1114–1119.Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo