1. bookVolume 13 (2013): Issue 3 (July 2013)
Journal Details
First Published
25 Nov 2011
Publication timeframe
4 times per year
access type Open Access

Bacteriocins In Poultry Nutrition – A Review / Bakteriocyny w żywieniu drobiu – artykuł przeglądowy

Published Online: 01 Aug 2013
Volume & Issue: Volume 13 (2013) - Issue 3 (July 2013)
Page range: 449 - 462
Journal Details
First Published
25 Nov 2011
Publication timeframe
4 times per year

In recent years, a number of studies have shown a close relationship between broiler performance, health and the gastrointestinal microbiota. However, taking the complexity and biodiversity of the micro-ecosystem into consideration, a manipulation of the microbiota in a way that is profitable both for the host bird and for the farmer seems a difficult goal to achieve. Bacteriocins are extracellular proteinaceous compounds, synthesized by many bacterial species. Due to their different bacteriostatic effects, they have been used in human nutrition for decades. However, limited information is available regarding their effects in poultry, even though that similar mode of action as in other animals is possible. Therefore, the aim of the present review is to discuss present bacteriocin classification, mode of action and their potential role in poultry nutrition.


Adebayo C.O., Aderiye B.I. (2011). Suspected mode of antimycotic action of brevicin SG1 against Candida albicans and Penicillium citrinum. Food Control, 22: 1814-1820.10.1016/j.foodcont.2011.04.013Open DOISearch in Google Scholar

Alloui M.N., Szczurek W., Świ ątkiewicz S. (2013). The usefulness of prebiotics and probiotics in modern poultry nutrition:areview. Ann. Anim. Sci., 13: 17-32.Search in Google Scholar

Audisio M.C., Oliver G., Apella M.C. (1999). Antagonistic effect of Enterococcus faecium J96 against human and poultry pathogenic Salmonella spp. J. Food Prot., 62: 751-755.Search in Google Scholar

Barnby - Smith F.M. (1992). Bacteriocins: applications in food preservation. Trends Food Sci. Technol., 3: 133-137.Search in Google Scholar

Belguesmia Y., Madi A., Sperandio D., Merieau A., Feuilloley M., Prevost H., Drider D., Connil N. (2011). Growing insights into the safety of bacteriocins: the case of enterocin S37. Res. Microbiol., 162: 159-163.10.1016/j.resmic.2010.09.019Open DOISearch in Google Scholar

Bordignon S.E., Miyaoka M.F., Spier M.R., Rubel R., Soccol V.T., Soccol C.R. (2011). Production biomolecule with inhibitory activity against Gram-negative bacteria isolated from faeces of broilers and swine. Braz. Arch. Biol. Technol., 54: 723-731.10.1590/S1516-89132011000400011Open DOISearch in Google Scholar

Choct M. (2009). Managing gut health through nutrition. Br. Poultry Sci., 50: 9-15.10.1080/00071660802538632Open DOISearch in Google Scholar

Cleveland J., Montville T.J., Nes I.F., Chikindas M.L. (2001). Bacteriocins: safe, natural antimicrobials for food preservation. Int. J. Food Microbiol., 71: 1-20.1176488610.1016/S0168-1605(01)00560-8Search in Google Scholar

Cole K., Farnell M., Donoghue A., Stern N., Svetoch E., Eruslanov B., Volo -dina L., Kovalev Y., Perelygin V., Mitsevich E. (2006). Bacteriocins reduce Campylobacter colonization and alter gut morphology in turkey poults. Poultry Sci., 85, p. 1570.10.1093/ps/85.9.157016977842Search in Google Scholar

Cotter P.D., Hill C., Ross R.P. (2005). Bacteriocins: Developing innate immunity for food. Nature Reviews Microbiology, 3: 777-788.1620571110.1038/nrmicro127316205711Search in Google Scholar

Dahiya J., Wilkie D., Van Kessel A., Drew M. (2006). Potential strategies for controlling necrotic enteritis in broiler chickens in post-antibiotic era. Anim. Feed Sci. Technol., 129: 60-88.10.1016/j.anifeedsci.2005.12.003Open DOISearch in Google Scholar

De Vuyst L., Leroy F. (2007). Bacteriocins from lactic acid bacteria: production, purification, and food applications. J. Mol. Microbiol. Biotechnol., 13: 194-199.10.1159/00010475217827969Open DOISearch in Google Scholar

Deegan L.H., Cotter P.D., Hill C., Ross P. (2006). Bacteriocins: Biological tools for bio-preservation and shelf-life extension. Int. Dairy J., 16: 1058-1071.10.1016/j.idairyj.2005.10.026Open DOISearch in Google Scholar

Diep D.B., Skaugen M., Salehian Z., Holo H., Nes I.F. (2007). Common mechanisms of target cell recognition and immunity for class IIbacteriocins. Proc. Natl. Acad. Sci. USA, 104: 2384-2389.10.1073/pnas.0608775104Open DOISearch in Google Scholar

Ennahar S., Sashihara T., Sonomoto K., Ishizaki A. (2000). Class IIa bacteriocins: biosynthesis, structure and activity. FEMS Microbiol. Rev., 24: 85-106.1064060010.1111/j.1574-6976.2000.tb00534.xSearch in Google Scholar

Galvez A., Abriouel H., Lopez R.L., Ben Omar N. (2007 a). Bacteriocin-based strategies for food biopreservation. Int. J. Food Microbiol., 120: 51-70.1761415110.1016/j.ijfoodmicro.2007.06.001Search in Google Scholar

Galvez A., Abriouel H., Lopez R.L, Omar N.B. (2007 b). Bacteriocin-based strategies for food biopreservation. Int. J. Food Microbiol., 120: 51-70.1761415110.1016/j.ijfoodmicro.2007.06.001Search in Google Scholar

Galvez A., Lopez R.L, Abriouel H., Valdivia E., Ben Omar N. (2008). Application of bacteriocins in the control of foodborne pathogenic and spoilage bacteria. Crit. Rev. Biotechnol., 28: 125-152.10.1080/0738855080210720218568851Open DOISearch in Google Scholar

Gholamiandehkordi A., Timbermont L., Lanckriet A., Broeck W.V.D., Peder-sen K., Dewulf J., Pasmans F., Haesebrouck F., Ducatelle R., Van Immerseel F. (2007). Quantification of gut lesions inasubclinical necrotic enteritis model. Avian Pathol., 36: 375-382.10.1080/03079450701589118Open DOISearch in Google Scholar

Grilli E., Messina M.R., Catelli E., Morlacchini M., Piva A. (2009). Pediocin Aimproves growth performance of broilers challenged with Clostridium perfringens. Poultry Sci., 88: 2152-2158.10.3382/ps.2009-00160Open DOISearch in Google Scholar

Hechard Y., Sahl H.D. (2002). Mode of action of modified and unmodified bacteriocins from Gram-positive bacteria. Biochimie, 84: 545-557.1242379910.1016/S0300-9084(02)01417-7Search in Google Scholar

Jack R., Tagg J., Ray B. (1995). Bacteriocins of gram-positive bacteria. Microbiol. Rev., 59: 171-200.760340810.1128/mr.59.2.171-200.19952393597603408Search in Google Scholar

Joerger R. (2003). Alternatives to antibiotics: bacteriocins, antimicrobial peptides and bacteriophages. Poultry Sci., 82, p. 640.10.1093/ps/82.4.64012710486Search in Google Scholar

Johansen C.H., Bjerrum L., Pedersen K. (2007). Impact of salinomycin on the intestinal microflora of broiler chickens. Acta Vet. Scand., 49, p. 30.1796348510.1186/1751-0147-49-30Search in Google Scholar

Józefiak D., Rutkowski A., Kaczmarek S., Jensen B.B., Engberg R.M., Hoj-berg O. (2010 a). Effect of β-glucanase and xylanase supplementation of barley- and rye-based diets on caecal microbiota of broiler chickens. Br. Poultry Sci., 51: 546-557.10.1080/00071668.2010.507243Open DOISearch in Google Scholar

Józefiak D., Rutkowski A., Martin S.A. (2004). Carbohydrate fermentation in the avian ceca:areview. Anim. Feed Sci. Technol., 113, pp. 1-15.10.1016/j.anifeedsci.2003.09.007Search in Google Scholar

Józefiak D., Sip A., Kaczmarek S., Rutkowski A. (2010 b). The effects of Carnobacteriumdivergens AS7 bacteriocin on gastrointestinal microflora in vitro and on nutrient retention in broiler chickens. J. Anim. Feed Sci., 19: 460-467.10.22358/jafs/66310/2010Search in Google Scholar

Józefiak D., Sip A., Rawski M., Rutkowski A., Kaczmarek S., Hojberg O., Jen-sen B.B., Engberg R.M. (2011 a). Dietary divercin modifies gastrointestinal microbiota and improves growth performance in broiler chickens. Br. Poultry Sci., 52: 492-499.10.1080/00071668.2011.602963Open DOISearch in Google Scholar

Józefiak D., Sip A., Rawski M., Steiner T., Rutkowski A. (2011 b). The dose response effects of liquid and lyophilized Carnobacterium divergens AS7 bacteriocin on the nutrient retention and performance of broiler chickens. J. Anim. Feed Sci., 20: 401-411.10.22358/jafs/66195/2011Search in Google Scholar

Józefiak D., Sip A., Rutkowski A., Rawski M., Kaczmarek S., Wolun- Chole- wa M., Engberg R.M., Hojberg O. (2012). Lyophilized Carnobacterium divergens AS7 bacteriocin preparation improves performance of broiler chickens challenged with Clostridium perfringens. Poultry Sci., 91: 1899-1907.10.3382/ps.2012-02151Open DOISearch in Google Scholar

Kaldhusdal M., Evensen O., Landsverk T. (1995). Clostridium perfringens necrotizing enteritis of the fowl:alight microscopic, immunohistochemical and ultrastructural study of spontaneous disease. Avian Pathol., 24: 421-433.10.1080/03079459508419082Open DOISearch in Google Scholar

Kaldhusdal M., Hofshagen M. (1992). Barley inclusion and avoparcin supplementation in broiler diets. 2. Clinical, pathological, and bacteriological findings inamild form of necrotic enteritis. Poultry Sci., 71: 1145-1153.Search in Google Scholar

Klaenhammer T.R. (1993). Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol. Rev., 12: 39-85.839821710.1016/0168-6445(93)90057-GSearch in Google Scholar

Laukova A., Guba P., Nemcova R., Vasilkova Z. (2003). Reduction of Salmonella in gnotobiotic Japanese quails caused by the enterocin A-producing EK13 strain of Enterococcus faecium. Vet. Res. Commun., 27: 275-280.10.1023/A:1024027923824Open DOISearch in Google Scholar

Le Blay G., Lacroix C., Zihler A., Fliss I. (2007). In vitro inhibition activity of nisin A, nisin Z, pediocin PA-1 and antibiotics against common intestinal bacteria. Lett. Appl. Microbiol., 45: 252-257.1771883510.1111/j.1472-765X.2007.02178.xSearch in Google Scholar

Leisner J.R.J., Laursen B.G, Pr Èvost H., Drider D., Dalgaard P. (2007). Carnobacterium: positive and negative effects in the environment and in foods. FEMS Microbiol. Rev., 31: 592-613.10.1111/j.1574-6976.2007.00080.xOpen DOISearch in Google Scholar

Line J.E., Svetoch E.A., Eruslanov B.V., Perelygin V.V., Mitsevich E.V., Mit-sevich I.P., Levchuk V.P., Svetoch O.E., Seal B.S., Siragusa G.R., Stern N.J. (2008). Isolation and purification of enterocin E-760 with broad antimicrobial activity against grampositive and gram-negative bacteria. Antimicrob. Agents Chemother., 52: 1094-1100.Search in Google Scholar

Lu J., Hofacre C., Smith F., Lee M.D. (2008). Effects of feed additives on the development on the ileal bacterial community of the broiler chicken. Animal, 2: 669-676.22443592Search in Google Scholar

Marugg J.D. (1991). Bacteriocins, their role in developing natural products. Food Biotechnol., 5: 305-312.10.1080/08905439109549812Open DOISearch in Google Scholar

Montville T.J., Winkowski K., Ludescher R.D. (1995). Models and mechanisms for bacteriocin action and application. Int. Dairy J., 5: 797-814.10.1016/0958-6946(95)00034-8Open DOISearch in Google Scholar

Musikasang H., Sohsomboon N., Tani A., Maneerat S. (2012). Bacteriocin-producing lactic acid bacteria asaprobiotic potential from Thai indigenous chickens. Czech J. Anim. Sci., 57: 137-149.Search in Google Scholar

Nava G.M., Bielke L.R., Callaway T.R., Castaneda M.P. (2005). Probiotic alternatives to reduce gastrointestinal infections: the poultry experience. Anim. Health Res. Rev., 6: 105-118.1616401210.1079/AHR2005103Search in Google Scholar

Nazef L., Belguesmia Y., Tani A., Prevost H., Drider D. (2008). Identification of lactic acid bacteria from poultry feces: evidence on anti-Campylobacter and anti-Listeria activities. Poultry Sci., 87, p. 329.10.3382/ps.2007-00282Search in Google Scholar

Nes I.F., Diep D.B, Havarstein L.S., Brurberg M.B., Eijsink V., Holo H. (1996). Biosynthesis of bacteriocins in lactic acid bacteria. Antonie Van Leeuwenhoek Int. J. Gen. Molec. Microbiol., 70: 113-128.Search in Google Scholar

O ' Sullivan L., Ross R.P., Hill C. (2002). Potential of bacteriocin-producing lactic acid bacteria for improvements in food safety and quality. Biochimie, 84: 593-604.10.1016/S0300-9084(02)01457-8Open DOISearch in Google Scholar

Ogunbanwo S.T., Sanni A.I., Onilude A.A. (2004). Influence of bacteriocin in the control of Escherichia coli infection of broiler chickens in Nigeria. World J. Microbiol. Biotechnol., 20: 51-56.Search in Google Scholar

Portrait V., Cottenceau G., Pons A.M. (2000). A Fusobacterium mortiferum strain producesabacteriocin-like substance(s) inhibiting Salmonella enteritidis. Lett. Appl. Microbiol., 31: 115-117.10.1046/j.1365-2672.2000.00774.x10972711Open DOISearch in Google Scholar

Rehman H., Vahjen W., Awad W., Zentek J. (2007). Indigenous bacteria and bacterial metabolic products in the gastrointestinal tract of broiler chickens. Archiv. Anim.319-335.10.1080/1745039070155681718030916Search in Google Scholar

Richard C., Cañon R., Naghmouchi K., Bertrand D., Pr ēvost H., Drider D. (2006). Evidence on correlation between number of disulfide bridge and toxicity of class IIa bacteriocins. Food Microbiol., 23: 175-183.10.1016/j.fm.2005.02.00116943002Open DOISearch in Google Scholar

Rihakova J., Petit V.W., Demnerova K., Prevost H., Rebuffat S., Drider D. (2009). Insights into Structure-Activity Relationships in the C-Terminal Region of Divercin V41,a Class IIa Bacteriocin with High-Level Antilisterial Activity. Applied and Environmental Microbiology, 7: 1811-1819.10.1128/AEM.02266-08266318819181835Open DOISearch in Google Scholar

Robyn J., Rasschaert G., Messens W., Pasmans F., Heyndrickx M. (2012). Screening for lactic acid bacteria capable of inhibiting Campylobacter jejuni in in vitro simulations of the broiler chicken caecal environment. Benef. Mirbobes, 3: 299-308.10.3920/BM2012.002123234730Open DOISearch in Google Scholar

Schillinger U., Geisen R., Holzapfel W.H. (1996). Potential of antagonistic microorganisms and bacteriocins for the biological preservation of foods. Trends Food Sci. Technol., 7: 158-164.Search in Google Scholar

Shin M.S., Han S.K., Ji A.R., Kim K.S., Lee W.K. (2008). Isolation and characterization of bacteriocin-producing bacteria from the gastrointestinal tract of broiler chickens for probiotic use. J. Appl. Microbiol., 105: 2203-2212.10.1111/j.1365-2672.2008.03935.x19120666Open DOISearch in Google Scholar

Sip A., Grajek W., Boyaval P. (1998). Enhancement of bacteriocin production by Carnobacteriumdivergens AS7 in the presence ofabacteriocin-sensitive strain Carnobacterium piscicola. Int. J. Food Microbiol., 42: 63-69.Search in Google Scholar

Stern N.J., Svetoch E.A., Eruslanov B.V., Kovalev Y.N., Volodina L.I., Perely -gin V.V., Mitsevich E.V., Mitsevich I.P., Levchuk V.P.. (2005). Paenibacillus polymyxa purified bacteriocin to control Campylobacter jejuni in chickens. J. Food Prot., 68: 1450-1453.Search in Google Scholar

Stern N.J., Svetoch E.A., Eruslanov B.V., Perelygin V.V., Mitsevich E.V., Mit-sevich I.P., Pokhilenko V.D., Levchuk V.P., Svetoch O.E., Seal B.S. (2006). Isolation ofaLactobacillus salivarius strain and purification of its bacteriocin, which is inhibitory to Campylobacter jejuni in the chicken gastrointestinal system. Antimicrob. Agents Chemother., 50: 3111-3116.Search in Google Scholar

Tahiri I., Desbiens M., Benech R., Kheadr E., Lacroix C., Thibault S., Ouel -let D., Fliss I. (2004). Purification, characterization and amino acid sequencing of divergicin M35:anovel class IIa bacteriocin produced by Carnobacterium divergens M35. Int. J. Food Microbiol., 97: 123-136.10.1016/j.ijfoodmicro.2004.04.01315541799Open DOISearch in Google Scholar

Totton S.C., Farrar A.M., Wilkins W., Bucher O., Waddell L.A., Wilhelm B.J., Mc - Ewen S.A., Rajic A. (2012). The effectiveness of selected feed and water additives for reducing Salmonella spp. of public health importance in broiler chickens: Asystematic review, meta-analysis, and meta-regression approach. Prev. Vet. Med., 106: 197-213.10.1016/j.prevetmed.2012.07.00722858425Open DOISearch in Google Scholar

Van Immerseel F., Rood J., Moore R., Titball R. (2009). Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol., pp. 32-36.10.1016/j.tim.2008.09.00518977143Search in Google Scholar

Williams R.B. (2005). Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity. Avian Pathol., 34: 159-180.10.1080/030794505001121951619169916191699Open DOISearch in Google Scholar

Wilson J., Tice G., Brash M.L., St Hilaire S. (2005). Manifestations of Clostridium perfringens and related bacterial enteritides in broiler chickens. Worlds Poultry Sci. J., 61: 435-449.Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo