<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Chronic kidney disease (CKD) is one of the clinical features characterized by progressive and irreversible loss of renal function. The incidence of this pathology is constantly increasing globally, due to the growing number of patients diagnosed with diabetes and hypertension, both diseases generating tubular fibrosis and kidney dysfunction. Through experimental models for the production of tubulo-interstitial fibrosis (TIF), we try to understand deeply and comprehensively the main pathogenic mechanisms that govern the onset, progression and worsening of CKD. Understanding the mechanisms underlying the production of this pathology, one can try therapeutic methods to produce an evolutionary slowdown in CKD and also translate the main benefits in clinical practice, based on these experimental models of basic research.</p>
</abstract>

Chronic kidney disease (CKD) is one of the clinical features characterized by progressive and irreversible loss of renal function. The incidence of this pathology is constantly increasing globally, due to the growing number of patients diagnosed with diabetes and hypertension, both diseases generating tubular fibrosis and kidney dysfunction. Through experimental models for the production of tubulo-interstitial fibrosis (TIF), we try to understand deeply and comprehensively the main pathogenic mechanisms that govern the onset, progression and worsening of CKD. Understanding the mechanisms underlying the production of this pathology, one can try therapeutic methods to produce an evolutionary slowdown in CKD and also translate the main benefits in clinical practice, based on these experimental models of basic research.

Some Models of Chronic Kidney Disease Induced in the Experimental Animal

“George Emil” Palade University of Medicine, Pharmacy, Science and Technology of Târgu-Mureș

Acta Medica Transilvanica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Some Models of Chronic Kidney Disease Induced in the Experimental Animal"}

Chronic kidney disease (CKD) is one of the clinical features characterized by progressive and irreversible loss of renal function. The incidence of this...

Some Models of Chronic Kidney Disease Induced in the Experimental Animal

Published Online: Jan 24, 2022

Page range: 53 - 55

Received: Oct 23, 2021

Accepted: Dec 02, 2021

DOI: https://doi.org/10.2478/amtsb-2021-0074

Keywords
chronic kidney disease (CKD), tubulointerstitial fibrosis (TIF)

© 2021 Mihai Ciprian Stoica et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Some Models of Chronic Kidney Disease Induced in the Experimental Animal

Published Online: Jan 24, 2022

Page range: 53 - 55

Received: Oct 23, 2021

Accepted: Dec 02, 2021

DOI: https://doi.org/10.2478/amtsb-2021-0074

Keywordschronic kidney disease (CKD), tubulointerstitial fibrosis (TIF)

© 2021 Mihai Ciprian Stoica et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
chronic kidney disease (CKD), tubulointerstitial fibrosis (TIF)