Detection of serum telomerase and fibronectin as precursor markers of cervix cancer in patients with a positive Pap test

1 Huang J., Qian Z., Gong Y., Wang Y., Guan Y., Han Y., et al. Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning. J. Med. Genet. 2018; 56:186–194. doi: 10.1136/jmedgenet-2018-105745. Open DOISearch in Google Scholar

2 American Cancer Society. Cancer facts & figures 2018. Atlanta, GA: American Cancer Society, 2018. Search in Google Scholar

3 World health Organization (2020). Global strategy to accelerate the elimination of cervical cancer as a public health problem. https://www.who.int/publications/i/item/9789240014107 Search in Google Scholar

4 Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021:71:209–49. doi:10.3322/caac.21660. Open DOISearch in Google Scholar

5 Todor RD, Bratucu G, Moga MA, Candrea AN, Marceanu LG, Anastasiu CV. Challenges in the Prevention of Cervical Cancer in Romania. Int J Environ Res Public Health. 2021 Feb 10;18(4):1721. doi: 10.3390/ijerph18041721. Open DOISearch in Google Scholar

6 Voidăzan, T.S.; Budianu, M.A.; Rozsnyai, F.F.; Kovacs, Z.; Uzun, C.C.; Neagu, N. Assessing the Level of Knowledge, Beliefs and Acceptance of HPV Vaccine: A Cross-Sectional Study in Romania. Int. J. Environ. Res. Public Health 2022, 19, 6939. https://doi.org/10.3390/ijerph19116939 Search in Google Scholar

7 Chatterjee S., Gupta D., Caputo T.A., Holcomb K. Disparities in Gynecological Malignancies. Front. Oncol. 2016; 6:36. doi: 10.3389/fonc.2016.00036. Open DOISearch in Google Scholar

8 Bosch FX, De Sanjosé S. The epidemiology of human papillomavirus infection and cervical cancer. Dis Markers 2007; 23(4): 213–227. Search in Google Scholar

9 Kahn J.A. HPV vaccination for the prevention of cervical intraepithelial neoplasia. N. Engl. J. Med. 2009; 361:271–278. doi: 10.1056/NEJMct0806938. Open DOISearch in Google Scholar

10 Tekalegn Y, Sahiledengle B, Woldeyohannes D, Atlaw D, Degno S, Desta F, et al. High parity is associated with increased risk of cervical cancer: Systematic review and meta-analysis of case-control studies. Womens Health (Lond). 2022;18:17455065221075904. doi: 10.1177/17455065221075904. Open DOISearch in Google Scholar

11 Chrysostomou A.C, Stylianou D.C, Constantinidou A, Kostrikis L.G. Cervical Cancer Screening Programs in Europe: The Transition Towards HPV Vaccination and Population-Based HPV Testing. Viruses. 2018 Dec 19;10(12):729. doi: 10.3390/v10120729. Open DOISearch in Google Scholar

12 Panczyszyn A., Bernacka E.B., Głab G., Telomeres and Telomerase During Human Papillomavirus Induced Carcinogenesis, Mol Diagn Ther, 2018 22:421–430 https://doi.org/10.1007/s40291-018-0336 Search in Google Scholar

13 Molano M., Martín D.C., Acosta P.M, Hernández G, Cornall A., Buitrago O., et al. Telomerase activity in cervical scrapes of women with high grade cervical disease: A nested case control study, Oncology Letters. 2017; 15:354-360, DOI: 10.3892/ol.2017.7324 Open DOISearch in Google Scholar

14 He, H.; Pan, Q.; Pan, J.; Chen, Y.; Cao, L. Study on the correlation between hTREC and HPV load and cervical CINI/II/III lesions and cervical cancer. J. Clin. Lab. Anal. 2020; 34, e23257. https://doi.org/10.1002/jcla.23257. Search in Google Scholar

15 Ji, W.; Lou, W.; Hong, Z.; Qiu, L.; Di, W. Genomic amplification of HPV, h‐TERC and c‐MYC in liquid‐based cytological specimens for screening of cervical intraepithelial neoplasia and cancer. Oncol. Lett. 2019; 17:2099–2106. https://doi.org/10.3892/ol.2018.9825. Search in Google Scholar

16 https://resources.rndsystems.com/pdfs/datasheets/dfbn10.pdf Search in Google Scholar

17 Voidăzan, S.T.; Dianzani, C.; Husariu, M.A.; Geréd, B.; Turdean, S.G.; Uzun, C.C.; Kovacs, Z.; Rozsnyai, F.F.; Neagu, N. The Role of p16/Ki‐67 Immunostaining, hTERC Amplification and Fibronectin in Predicting Cervical Cancer Progression: A Systematic Review. Biology 2022, 11, 956. https://doi.org/10.3390/biology11070956 Search in Google Scholar

18 Nayar R, Wilbur DC. The Pap test and Bethesda. Cancer Cytopathol 2015;123:271–81. Search in Google Scholar

19 Jahic M, Jahic E. Diagnostic approach to patients with atypical squamous cells of undetermined significance cytologic findings on cervix. Med Arch 2016;70:296–8. Search in Google Scholar

20 https://www.lsbio.com/elisakits/manualpdf/ls-f12713.pdf Search in Google Scholar