<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Introduction</bold>: Cervical cancer is a type of cancer that appears in cervical cells, in the lower part of the uterus, being characterized by the proliferation of atypical cancerous cells, which can spread rapidly, representing a serious disease, with significant medical and social impact among affected individuals, and a severe evolution particularly when detected in advanced stages. The aim of this study was to evaluate the alterations found in cervical cells, caused by persistent HPV infection, using inflammatory protein biomarkers such as fibronectin and telomerase.
<bold>Material and method</bold>: This study included a total of 169 women, both asymptomatic and symptomatic, aged between 30 and 64 years. Those women underwent routine gynecological consultations or were referred to a gynecologist because of their symptoms. After selecting the patients, a Pap test and blood samples (5 ml) were taken. Using a questionnaire, information regarding sexual characteristics and behaviors, as well as personal medical history, were collected.
<bold>Results</bold>: The median value for telomerase was 0.1 ng/ml, with a minimum of 0.01 ng/ml and a maximum of 30.09 ng/ml. Based on the telomerase results, 66 (39.1%) patients had positive results (more than 0.215 units) and 103 (60.9%) had negative results. The median value for fibronectin was 3.72 ng/ml with a minimum of 0.55 ng/ml and a maximum of 89.9 ng/ml. Of all women included in the study, 36 (21.3%) had positive results (more than 10 ng/ml), and 133 (78.7%) had negative results. Also, 15.2% of patients with positive telomerase and 16.7% with positive fibronectin presented Atypical Squamous Cells of Undetermined Significance. Mature squamous metaplasia and inflammatory cells have been identified among positive and negative results of fibronectin and telomerase.
<bold>Conclusions</bold>: Positive and negative results for fibronectin and telomerase were similar in correlation with cytological results and information about HPV infection or sexual practices/characteristics were similar.
</abstract>

Introduction: Cervical cancer is a type of cancer that appears in cervical cells, in the lower part of the uterus, being characterized by the proliferation of atypical cancerous cells, which can spread rapidly, representing a serious disease, with significant medical and social impact among affected individuals, and a severe evolution particularly when detected in advanced stages. The aim of this study was to evaluate the alterations found in cervical cells, caused by persistent HPV infection, using inflammatory protein biomarkers such as fibronectin and telomerase.
Material and method: This study included a total of 169 women, both asymptomatic and symptomatic, aged between 30 and 64 years. Those women underwent routine gynecological consultations or were referred to a gynecologist because of their symptoms. After selecting the patients, a Pap test and blood samples (5 ml) were taken. Using a questionnaire, information regarding sexual characteristics and behaviors, as well as personal medical history, were collected.
Results: The median value for telomerase was 0.1 ng/ml, with a minimum of 0.01 ng/ml and a maximum of 30.09 ng/ml. Based on the telomerase results, 66 (39.1%) patients had positive results (more than 0.215 units) and 103 (60.9%) had negative results. The median value for fibronectin was 3.72 ng/ml with a minimum of 0.55 ng/ml and a maximum of 89.9 ng/ml. Of all women included in the study, 36 (21.3%) had positive results (more than 10 ng/ml), and 133 (78.7%) had negative results. Also, 15.2% of patients with positive telomerase and 16.7% with positive fibronectin presented Atypical Squamous Cells of Undetermined Significance. Mature squamous metaplasia and inflammatory cells have been identified among positive and negative results of fibronectin and telomerase.
Conclusions: Positive and negative results for fibronectin and telomerase were similar in correlation with cytological results and information about HPV infection or sexual practices/characteristics were similar.

Detection of serum telomerase and fibronectin as precursor markers of cervix cancer in patients with a positive Pap test

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures

Department of Biochemistry, Environmental Chemistry

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction: Cervical cancer is a type of cancer that appears in cervical cells, in the lower part of the uterus, being characterized by the proliferation of...

Detection of serum telomerase and fibronectin as precursor markers of cervix cancer in patients with a positive Pap test

Published Online: Jun 30, 2023

Page range: 121 - 127

Received: Mar 08, 2023

Accepted: May 11, 2023

DOI: https://doi.org/10.2478/amma-2023-0021

Keywords
cervical cancer, screening, human papillomavirus, fibronectin, telomerase

© 2023 Toader Septimiu Voidăzan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Detection of serum telomerase and fibronectin as precursor markers of cervix cancer in patients with a positive Pap test

Published Online: Jun 30, 2023

Page range: 121 - 127

Received: Mar 08, 2023

Accepted: May 11, 2023

DOI: https://doi.org/10.2478/amma-2023-0021

Keywordscervical cancer, screening, human papillomavirus, fibronectin, telomerase

© 2023 Toader Septimiu Voidăzan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
cervical cancer, screening, human papillomavirus, fibronectin, telomerase