<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Human Papillomavirus (HPV) associated with oropharyngeal and oral squamous cell carcinoma (OPSCC and OSCC) is escalating over the years. Hence, the present review aims to determine the prevalence of HPV-OSCC and HPV-OPSCC in Asian countries over the last decades. An electronic search was conducted using nine online databases to identify English-language articles on the prevalence of HPV-OPSCC and HPV-OSCC in Asian countries from January 2011 to June 2022. The risk of bias was assessed using the JBI critical appraisal checklist and the level of evidence was determined based on the OCEBM guideline. Single-arm meta-analysis was used to estimate the weighted mean prevalence of HPV-OPSCC and HPV-OSCC among patients in Asia. Subgroup analysis meta-regression and Egger’s tests were also conducted. 59 eligible studies were included with a higher prevalence of HPV-OPSCC (32.6%-37.4%) as compared to HPV-OSCC (10.9%-23.5%). Subgroup analysis revealed that the weighted mean prevalence of HPV-OPSCC was significantly higher (P&lt;0.001) among East Asians, while the weighted mean prevalence of HPV-OSCC was significantly higher (P&lt;0.001) among South Asians. All studies showed a low to moderate risk of bias with the level of evidence ranked between 2 and 3. The diagnostic tools utilised and geographical locations significantly affect the findings.</p>
</abstract>

Human Papillomavirus (HPV) associated with oropharyngeal and oral squamous cell carcinoma (OPSCC and OSCC) is escalating over the years. Hence, the present review aims to determine the prevalence of HPV-OSCC and HPV-OPSCC in Asian countries over the last decades. An electronic search was conducted using nine online databases to identify English-language articles on the prevalence of HPV-OPSCC and HPV-OSCC in Asian countries from January 2011 to June 2022. The risk of bias was assessed using the JBI critical appraisal checklist and the level of evidence was determined based on the OCEBM guideline. Single-arm meta-analysis was used to estimate the weighted mean prevalence of HPV-OPSCC and HPV-OSCC among patients in Asia. Subgroup analysis meta-regression and Egger’s tests were also conducted. 59 eligible studies were included with a higher prevalence of HPV-OPSCC (32.6%-37.4%) as compared to HPV-OSCC (10.9%-23.5%). Subgroup analysis revealed that the weighted mean prevalence of HPV-OPSCC was significantly higher (P<0.001) among East Asians, while the weighted mean prevalence of HPV-OSCC was significantly higher (P<0.001) among South Asians. All studies showed a low to moderate risk of bias with the level of evidence ranked between 2 and 3. The diagnostic tools utilised and geographical locations significantly affect the findings.

Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis

Oral and Maxillofacial Surgery Department, Dental Specialist Clinic, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry

Department of Dental Materials, Faculty of Dentistry, Asian Institute of Medicine

Science and Technology (AIMST) University

Department of Paediatric Dentistry & Orthodontics, Faculty of Dentistry

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

Human Papillomavirus (HPV) associated with oropharyngeal and oral squamous cell carcinoma (OPSCC and OSCC) is escalating over the years. Hence, the present...

Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis

Published Online: Jun 30, 2023

Page range: 77 - 92

Received: Jan 12, 2023

Accepted: Feb 05, 2023

DOI: https://doi.org/10.2478/amma-2023-0005

Keywords
Asia, epidemiology, mouth neoplasm, HPV, polymerase chain reaction

© 2023 Yy Jean Tan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis

Published Online: Jun 30, 2023

Page range: 77 - 92

Received: Jan 12, 2023

Accepted: Feb 05, 2023

DOI: https://doi.org/10.2478/amma-2023-0005

KeywordsAsia, epidemiology, mouth neoplasm, HPV, polymerase chain reaction

© 2023 Yy Jean Tan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
Asia, epidemiology, mouth neoplasm, HPV, polymerase chain reaction