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Evaluating the Reliability of Cytological Analysis in Diagnosing Malignant Pleural Effusions: Challenges and Implications

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Sep 09, 2025

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Skok K, Hladnik G, Grm A, Crnjac A. Malignant Pleural Effusion and Its Current Management: A Review. Medicina (Kaunas). 2019 Aug 15;55(8):490. doi: 10.3390/medicina55080490. Search in Google Scholar

Piggott LM, Hayes C, Greene J, Fitzgerald DB. Malignant pleural disease. Breathe (Sheff). 2023 Dec;19(4):230145. doi: 10.1183/20734735.0145-2023. Search in Google Scholar

Wang ST, Chen CL, Liang SH, et al. Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature. Open Med (Wars). 2021 Mar 12;16(1):387-396. doi: 10.1515/med-2021-0243. Search in Google Scholar

Jimenez Castro D, Diaz Nuevo G, Perez-Rodriguez E, Light RW. Diagnostic value of adenosine deaminase in nontuberculous lymphocytic pleural effusions. Eur Respir J 2003; 21:220–4. Search in Google Scholar

Wu H, Khosla R, Rohatgi PK, et al. The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective study. Lung India. 2017 Jan-Feb;34(1):34-37. doi: 10.4103/0970-2113.197120. Search in Google Scholar

Pairman L, Beckert LEL, Dagger M, Maze MJ. Evaluation of pleural fluid cytology for the diagnosis of malignant pleural effusion: a retrospective cohort study. Intern Med J. 2022 Jul;52(7):1154-1159. doi: 10.1111/imj.15725. Search in Google Scholar

Shidham VB, Layfield LJ. Approach to Diagnostic Cytopathology of Serous Effusions. Cytojournal. 2021 Dec 6; 18:32. doi: 10.25259/CMAS_02_03_2021. Search in Google Scholar

Abramowitz Y, Simanovsky N, Goldstein MS, Hiller N. Pleural effusion: characterization with CT attenuation values and CT appearance. AJR Am J Roentgenol. 2009 Mar;192(3):618-23. doi: 10.2214/AJR.08.1286. Search in Google Scholar

Priddy-Arrington MA, Niu S, Wilson EM, et al. The Cytological Diagnosis of a Malignant Effusion Is Independent of the Volume of Fluid Processed. Diagn Cytopathol. 2024 Oct 30. doi: 10.1002/dc.25416. Epub ahead of print. Search in Google Scholar

Gurung P, Goldblatt M, Huggins JT, et al. Pleural fluid analysis and radiographic, sonographic, and echocardiographic characteristics of hepatic hydrothorax. Chest. 2011 Aug;140(2):448-453. doi: 10.1378/chest.10-2134. Search in Google Scholar

Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Basic Medical Science, Immunology, Clinical Medicine, Clinical Medicine, other