Aronia Melanocarpa Fruit Juice Ameliorates the Histopathological Changes in the Myocardium and Coronary Arteries in a Rat Metabolic Syndrome Model

1Tune JD, Goodwill AG, Sassoon DJ et al. Cardiovascular consequences of metabolic syndrome. Transl Res. 2017;183:57-70.Search in Google Scholar

2Gao Y, Ren Y, Guo YK et al. Metabolic syndrome and myocardium steatosis in subclinical type 2 diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Cardiovasc Diabetol. 2020;19(1):70.Search in Google Scholar

3Li ZL, Woollard JR, Ebrahimi B et al. Transition from obesity to metabolic syndrome is associated with altered myocardial autophagy and apoptosis. Arterioscler Thromb Vasc Biol. 2012;32(5):1132-41.Search in Google Scholar

4Zheng M, Choi SY, Tahk SJ et al. The relationship between volumetric plaque components and classical cardiovascular risk factors and the metabolic syndrome a 3-vessel coronary artery virtual histology-intravascular ultrasound analysis. JACC Cardiovasc Interv. 2011;4(5):503-10.Search in Google Scholar

5Parzonko A, Naruszewicz M. Cardioprotective effects of Aronia melanocarpa anthocynanins. From laboratory experiments to clinical practice. Curr Pharm Des. 2016;22(2):174-9.Search in Google Scholar

6Valcheva-Kuzmanova S, Denev P, Krachanova M et al. Composition and antioxidant acitivity of Aronia Melanocarpa fruit juice. Varna Med Forum. 2014;3(1):15-20. Search in Google Scholar

7Koba S. Angiotensin II, oxidative stress, and sympathetic nervous system hyperactivity in heart failure. Yonago Acta Med. 2018;61(2):103-9.Search in Google Scholar

8Bruno RM, Ghiadoni L, Seravalle G et al. Sympathetic regulation of vascular function in health and disease. Front Physiol. 2012;3:284.Search in Google Scholar

9Aroor AR, Demarco VG, Jia G et al. The role of tissue reninangiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness. Front Endocrinol (Lausanne). 2013;4:161.Search in Google Scholar

10Blann AD. Endothelial cell activation, injury, damage and dys-function: separate entities or mutual terms? Blood Coagul Fibrinolysis. 2000;11(7):623-30.Search in Google Scholar

11Tran V, De Silva TM, Sobey CG et al. The vascular consequences of metabolic syndrome: rodent models, endothelial dysfunction, and current therapies. Front Pharmacol. 2020;11:148.Search in Google Scholar

12Death AK, Fisher EJ, McGrath KC et al. High glucose alters matrix metalloproteinase expression in two key vascular cells: potential impact on atherosclerosis in diabetes. Atherosclerosis. 2003;168(2):263-9.Search in Google Scholar

13Daskalova E, Delchev S, Peeva Y et al. Antiatherogenic and cardioprotective effects of black chokeberry (Aronia melanocarpa) juice in aging rats. Evid Based Complement Alternat Med. 2015;2015:717439.Search in Google Scholar

14Daskalova E, Delchev S, Vladimirova-Kitova L et al. Aronia melanocarpa fruit juice modulates ACE2 immunoexpression and diminishes age-related remodeling of coronary arteries in rats. Foods. 2022;11(9):1220.Search in Google Scholar

15Jadeja RN, Upadhyay KK, Devkar RV et al. Naturally occurring Nrf2 activators: potential in treatment of liver injury. Oxid Med Cell Longev. 2016;2016:3453926.Search in Google Scholar

16Akhlaghi M, Bandy B. Preconditioning and acute effects of flavonoids in protecting cardiomyocytes from oxidative cell death. Oxid Med Cell Longev. 2012;2012:782321.Search in Google Scholar

17Isaak CK, Petkau JC, Blewett H et al. Lingonberry anthocyanins protect cardiac cells from oxidative-stress-induced apoptosis. Can J Physiol Pharmacol. 2017;95(8):904-10.Search in Google Scholar

18Louis XL, Thandapilly SJ, Kalt W et al. Blueberry polyphenols prevent cardiomyocyte death by preventing calpain activation and oxidative stress. Food Funct. 2014;5(8):1785-94.Search in Google Scholar

19Thandapilly SJ, Louis XL, Yang T, et al. Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway. Eur J Pharmacol. 2011;668(1-2):217-24.Search in Google Scholar

20Parichatikanond W, Pinthong D, Mangmool S. Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin. Planta Med. 2012;78(15):1626-32.Search in Google Scholar

21Santos IB, de Bem GF, da Costa CA et al. Açaí seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet-fed mice. Nutr Res. 2020;79:35-49.Search in Google Scholar

22Kim JH, Auger C, Kurita I, et al. Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase. Nitric Oxide. 2013;35:54-64.Search in Google Scholar

23Iwashima T, Kudome Y, Kishimoto Y et al. Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3. Food Nutr Res. 2019;63.Search in Google Scholar

24Zapolska-Downar D, Bryk D, Małecki M et al. Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells. Eur J Nutr. 2012;51(5):563-72.Search in Google Scholar