<abstract xmlns="http://www.w3.org/1999/xhtml">
<sec><h3>Aim: </h3>
<p>The purpose of this study was to examine the effect of Aronia melanocarpa fruit juice (AMFJ) on the histology of the myocardium and coronary arteries in metabolic syndrome (MS) rats. </p>
</sec>
<sec><h3>Materials and methods: </h3>
<p>The animals were divided into five groups: control, MS, MS+AMFJ2.5, MS+AMFJ5, and MS+AMFJ10. For 10 weeks, the control group received regular rat chaw and tap water, the other groups – high-fat, high-fructose diet and 10% fructose in their drinking water to induce MS. Throughout the experiment, rats received a daily oral treatment: the control and MS groups – 10 ml/kg distilled water, the other groups – AMFJ at doses of 2.5, 5.0, and 10.0 ml/kg, respectively. At the end of the experimental period, the animals were sacrificed and tissue samples from the myocardium and coronary arteries were evaluated histologically.</p>
</sec>
<sec><h3>Results: </h3>
<p>In the MS group, degeneration of the cardiomyocytes and endothelial cell necrosis were detected. In the MS+AMFJ2.5 group, cardiomyocyte damage was decreased, the endothelium was damaged and the preserved cells were activated. In MS+AMFJ5 and MS+AMFJ10 groups, the myocardium and the endothelial layer of the coronary arteries were preserved.</p>
</sec>
<sec><h3>Conclusion: </h3>
<p>These results indicate cardio- and vasoprotective effects of the juice.</p>
</sec>
</abstract>

Aim: 
The purpose of this study was to examine the effect of Aronia melanocarpa fruit juice (AMFJ) on the histology of the myocardium and coronary arteries in metabolic syndrome (MS) rats. 

Materials and methods: 
The animals were divided into five groups: control, MS, MS+AMFJ2.5, MS+AMFJ5, and MS+AMFJ10. For 10 weeks, the control group received regular rat chaw and tap water, the other groups – high-fat, high-fructose diet and 10% fructose in their drinking water to induce MS. Throughout the experiment, rats received a daily oral treatment: the control and MS groups – 10 ml/kg distilled water, the other groups – AMFJ at doses of 2.5, 5.0, and 10.0 ml/kg, respectively. At the end of the experimental period, the animals were sacrificed and tissue samples from the myocardium and coronary arteries were evaluated histologically.

Results: 
In the MS group, degeneration of the cardiomyocytes and endothelial cell necrosis were detected. In the MS+AMFJ2.5 group, cardiomyocyte damage was decreased, the endothelium was damaged and the preserved cells were activated. In MS+AMFJ5 and MS+AMFJ10 groups, the myocardium and the endothelial layer of the coronary arteries were preserved.

Conclusion: 
These results indicate cardio- and vasoprotective effects of the juice.

Aronia Melanocarpa Fruit Juice Ameliorates the Histopathological Changes in the Myocardium and Coronary Arteries in a Rat Metabolic Syndrome Model

Department of Pharmacology and Clinical Pharmacology and Therapeutics, Faculty of Medicine

Medical University Prof. Dr. Paraskev Stoyanov – Varna

Department of Basic and Clinical Pathology

Forensic Medicine and Deontology, Faculty of Medicine,  Medical University Prof. Dr. Paraskev Stoyanov – Varna

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Aim: 
The purpose of this study was to examine the effect of Aronia melanocarpa fruit juice (AMFJ) on the histology of the myocardium and coronary arteries in...

Aronia Melanocarpa Fruit Juice Ameliorates the Histopathological Changes in the Myocardium and Coronary Arteries in a Rat Metabolic Syndrome Model

Published Online: Sep 29, 2023

Page range: 36 - 40

Received: Feb 28, 2023

Accepted: Aug 13, 2023

DOI: https://doi.org/10.2478/amb-2023-0028

Keywords
Aronia melanocarpa, histology, myocardium, coronary artery, metabolic syndrome

© 2023 M. Reyzov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Aronia Melanocarpa Fruit Juice Ameliorates the Histopathological Changes in the Myocardium and Coronary Arteries in a Rat Metabolic Syndrome Model

Published Online: Sep 29, 2023

Page range: 36 - 40

Received: Feb 28, 2023

Accepted: Aug 13, 2023

DOI: https://doi.org/10.2478/amb-2023-0028

KeywordsAronia melanocarpa, histology, myocardium, coronary artery, metabolic syndrome

© 2023 M. Reyzov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Aronia melanocarpa, histology, myocardium, coronary artery, metabolic syndrome