AV-153-Na (mg/kg) | Kidneys fold difference (SEM range) | Liver fold difference (SEM range) | |
---|---|---|---|
Control | 1.00 (0.97–1.03) | 1.00 (0.95–1.05) | |
0.05 | 1.28 (1.21–1.35)* | 0.94 (0.82–1.08) | |
0.50 | 1.28 (1.12–1.46)* | 1.23 (1.19–1.26) | |
Control | 1.00 (0.99–1.02) | 1.00 (0.94–1.04) | |
0.05 | 1.64 (1.51–1.78)*** | 0.79 (0.71–0.87)* | |
0.50 | 1.68 (1.47–1.91)*** | 1.09 (1.08–1.11) | |
Control | 1.00 (0.97–1.03) | 1.00 (0.92–1.09) | |
0.05 | 1.39 (1.29–1.51)** | 1.19 (1.07–1.33) | |
0.50 | 1.47 (1.30–1.66)** | 1.61 (1.59–1.62)* | |
Control | 1.00 (0.92–1.08) | 1.00 (0.94–1.06) | |
0.05 | 2.00 (1.78–2.25)*** | 1.49 (1.32–1.68)** | |
0.50 | 2.17 (1.87–2.52)*** | 1.91 (1.86–1.95)*** |
AV-153-Ca (mg/kg) | Kidney fold difference (SEM range) | Liver fold difference (SEM range) | |
---|---|---|---|
Control | 1.00 (0.97–1.03) | 1.00 (0.95–1.05) | |
0.05 | 0.89 (0.76–1.03) | 0.96 (0.94–0.99) | |
0.50 | 1.00 (0.92–1.09) | 0.89 (0.81–0.97) | |
Control | 1.00 (0.99–1.02) | 1.00 (0.94–1.04) | |
0.05 | 0.62 (0.55–0.71)** | 1.05 (1.03–1.08) | |
0.50 | 0.85 (0.75–0.95) | 0.82 (0.71–0.95) | |
Control | 1.00 (0.97–1.03) | 1.00 (0.92–1.09) | |
0.05 | 0.85 (0.77–0.93) | 0.89 (0.86–0.93) | |
0.50 | 0.90 (0.84–0.96) | 0.96 (0.88–1.05) | |
Control | 1.00 (0.92–1.08) | 1.00 (0.94–1.06) | |
0.05 | 1.03 (0.96–1.11) | 0.87 (0.82–0.93) | |
0.50 | 0.98 (0.89–1.07) | 1.35 (1.22–1.48)* |
Kidneys | Blood | |||||||
---|---|---|---|---|---|---|---|---|
Control | 20,6336 | 21,2849 | 20,2966 | 18,5916 | 19,3183 | 24,7317 | 23,9346 | 23,4343 |
19,9632 | 21,0402 | 20,1468 | 18,5301 | 19,1140 | 24,9544 | 23,9330 | 23,6485 | |
20,5162 | 20,6843 | 19,9793 | 18,4140 | 19,5568 | 23,5918 | 23,6477 | 22,6171 | |
19,7661 | 20,8542 | 20,0899 | 18,4168 | 19,5473 | 25,3724 | 23,5371 | 23,2719 | |
20,4493 | 21,1992 | 20,3281 | 18,7329 | 19,2752 | 24,2432 | 23,6730 | 22,2758 | |
20,0575 | 20,7519 | 19,8123 | 18,2283 | 18,0247 | 24,1311 | 23,7417 | 21,8996 | |
19,8994 | 20,8551 | 20,1670 | 18,5733 | 19,6721 | 24,1230 | 22,6278 | 22,9333 | |
19,9792 | 21,2709 | 20,5719 | 18,8297 | 18,5737 | 23,8446 | 23,0603 | 22,4729 | |
20,3273 | 21,4559 | 20,4872 | 18,9060 | 18,9473 | 24,8475 | 24,5772 | 23,0626 | |
20,7163 | 21,1733 | 20,4132 | 18,8730 | 19,7215 | 24,5549 | 23,4031 | 23,6338 | |
20,1879 | 21,1945 | 20,4594 | 18,7461 | 18,7025 | 24,7850 | 24,1693 | ||
18,7703 | 24,3940 | 24,0506 | ||||||
Metcarbatone 0.05 mg/kg | 21,1421 | 21,1700 | 20,2690 | 18,7102 | 19,1992 | 24,9793 | 24,9819 | 23,4209 |
20,6063 | 20,9449 | 20,0149 | 18,6103 | 18,2122 | 25,0053 | 24,6967 | 22,8411 | |
20,9352 | 21,4263 | 20,5656 | 18,9078 | 19,6951 | 24,3028 | 23,8090 | 22,9598 | |
20,5415 | 20,9494 | 20,0938 | 18,4946 | 18,7135 | 24,5634 | 24,1763 | 22,6806 | |
Metcarbatone 0.5 mg/kg | 20,8324 | 20,9915 | 20,1140 | 18,8390 | 18,9062 | 25,2567 | 23,8337 | 23,6736 |
21,1187 | 21,0831 | 20,1682 | 18,7917 | 19,2715 | 25,2724 | 24,5450 | 23,6550 | |
21,0912 | 21,1248 | 20,3896 | 18,8515 | 18,5728 | 24,6956 | 23,9355 | 22,8742 | |
20,6640 | 21,1151 | 20,0875 | 18,7441 | 18,6701 | 25,2925 | 24,5882 | 23,2121 | |
Etcarbatone 0.05 mg/kg | 20,6521 | 21,3114 | 20,2236 | 18,6247 | 18,8542 | 24,8812 | 24,1604 | 22,9606 |
21,2283 | 21,3560 | 20,3069 | 18,6993 | 19,1319 | 24,8758 | 24,7965 | 22,9433 | |
21,3387 | 21,4437 | 20,1647 | 18,7293 | 18,1798 | 24,6700 | 24,4486 | 22,5183 | |
Etcarbatone 0.5 mg/kg | 20,6957 | 21,2241 | 20,1316 | 18,4727 | 19,2888 | 24,9479 | 24,4943 | 23,1595 |
21,4283 | 21,6113 | 20,5876 | 18,8926 | 19,2577 | 24,8016 | 24,0260 | 23,0911 | |
21,0995 | 21,5415 | 20,3180 | 18,8051 | 18,9519 | 24,5479 | 24,2079 | 22,4058 | |
20,9716 | 21,4134 | 20,4994 | 18,8108 | 19,0836 | 24,6532 | 24,6596 | 22,5140 | |
Styrylcarbatone 0.05 mg/kg | 21,4476 | 21,4452 | 20,5627 | 18,6984 | 19,5796 | 23,9558 | 23,0535 | 22,6217 |
20,9010 | 21,0415 | 20,1628 | 18,3986 | 19,0160 | 24,8889 | 24,1739 | 23,2842 | |
21,3434 | 21,2509 | 20,2865 | 18,6662 | 18,1215 | 23,5157 | 23,3238 | 21,4245 | |
21,6191 | 22,0462 | 21,5846 | 18,9777 | 19,5722 | 25,4267 | 24,9225 | 23,4448 | |
Styrylcarbatone 0.5 mg/kg | 21,5660 | 21,5113 | 21,2236 | 18,9375 | 19,1745 | 23,8688 | 23,2048 | 22,2596 |
21,2131 | 21,5601 | 20,7720 | 18,7713 | 19,5076 | 24,7026 | 23,6100 | 23,0168 | |
21,0897 | 21,4685 | 20,4881 | 18,7617 | 18,9420 | 24,6156 | 23,8653 | 23,2664 | |
21,4455 | 21,6779 | 20,9215 | 18,9282 | |||||
Glutapyrone 0.05 mg/kg | 22,0678 | 22,8544 | 21,6248 | 19,8827 | 18,9078 | 23,7505 | 22,4539 | 22,0790 |
21,0281 | 22,1696 | 20,8820 | 19,3440 | 19,1537 | 23,5877 | 22,7654 | 22,3149 | |
21,1787 | 21,9149 | 20,8096 | 19,0287 | 20,1436 | 25,5499 | 23,8626 | 23,8251 | |
21,3287 | 21,5062 | 20,4549 | 18,7512 | 19,6614 | 24,1258 | 23,0498 | 23,1506 | |
Glutapyrone 0.5 mg/kg | 21,0105 | 21,8076 | 20,5749 | 18,8806 | 19,3639 | 24,6586 | 23,1130 | 22,9958 |
20,6910 | 21,6908 | 20,2656 | 18,6775 | 19,6876 | 25,6195 | 23,7417 | 24,0393 | |
21,1142 | 21,4909 | 20,2270 | 18,7062 | 19,4588 | 24,3839 | 23,1421 | 22,8727 | |
21,3715 | 21,4707 | 20,0467 | 18,8292 | 19,4118 | 24,7691 | 23,3703 | 23,2199 |
Metcarbatone (mg/kg) | Kidney fold difference (SEM range) | Blood fold difference (SEM range) | |
---|---|---|---|
Control | 1.00 (0.93–1.07) | 1.00 (0.87–1.14) | |
0.05 | 1.44 (1.34–1.54)* | 0.76 (0.56–1.04) | |
0.50 | 1.61 (1.50–1.74)** | 0.53 (0.48–0.58) | |
Control | 1.00 (0.93–1.08) | 1.00 (0.84–1.18) | |
0.05 | 1.51 (1.40–1.63)** | 0.55 (0.39–0.77) | |
0.50 | 1.69 (1.60–1.79)** | 0.58 (0.51–0.67) | |
Control | 1.00 (0.94–1.07) | 1.00 (0.90–1.12) | |
0.05 | 1.43 (1.34–1.54)* | 0.83 (0.68–1.01) | |
0.50 | 1.43 (1.34–1.53)* | 0.60 (0.55–0.64)* |
Glutapyrone (mg/kg) | Kidney fold difference (SEM range) | Blood fold difference (SEM range) | |
---|---|---|---|
Control | 1.00 (0.93–1.07) | 1.00 (0.87–1.14) | |
0.05 | 1.10 (0.95–1.26) | 1.49 (1.27–1.74) | |
0.50 | 1.21 (1.05–1.39) | 0.99 (0.86–1.14) | |
Control | 1.00 (0.93–1.08) | 1.00 (0.84–1.18) | |
0.05 | 1.40 (1.26–1.55) | 2.04 (1.94–2.14)* | |
0.50 | 1.73 (1.49–2.01)** | 1.66 (1.56–1.77) | |
Control | 1.00 (0.94–1.07) | 1.00 (0.90–1.12) | |
0.05 | 1.46 (1.28–1.66)* | 1.30 (1.19–1.42) | |
0.50 | 1.59 (1.46–1.73)** | 0.96 (0.84–1.11) |
Styrylcarbatone (mg/kg) | Kidney fold difference (SEM range) | Blood fold difference (SEM range) | |
---|---|---|---|
Control | 1.00 (0.93–1.07) | 1.00 (0.87–1.14) | |
0.05 | 1.65 (1.53–1.79)** | 0.99 (0.78–1.26) | |
0.50 | 1.53 (1.43–1.64)** | 1.13 (0.93–1.37) | |
Control | 1.00 (0.93–1.08) | 1.00 (0.84–1.18) | |
0.05 | 1.63 (1.39–1.90)** | 0.87 (0.64–1.18) | |
0.50 | 1.41 (1.36–1.47)* | 1.18 (0.97–1.44) | |
Control | 1.00 (0.94–1.07) | 1.00 (0.90–1.12) | |
0.05 | 2.05 (1.98–2.13)*** | 1.09 (0.90–1.32) | |
0.50 | 1.83 (1.75–1.91)*** | 1.08 (0.84–1.39) |
Etcarbatone (mg/kg) | Kidney fold difference (SEM range) | Blood fold difference (SEM range) | |
---|---|---|---|
Control | 1.00 (0.93–1.07) | 1.00 (0.87–1.14) | |
0.05 | 1.46 (1.29–1.65)* | 0.61 (0.52–0.70) | |
0.50 | 1.36 (1.29–1.43)* | 0.85 (0.84–0.87) | |
Control | 1.00 (0.93–1.08) | 1.00 (0.84–1.18) | |
0.05 | 1.82 (1.56–2.12)** | 0.45 (0.37–0.55) | |
0.50 | 1.61 (1.52–1.71)** | 0.66 (0.59–0.74) | |
Control | 1.00 (0.94–1.07) | 1.00 (0.90–1.12) | |
0.05 | 1.72 (1.52–1.95)** | 0.79 (0.71–0.88) | |
0.50 | 1.62 (1.53–1.72)** | 1.07 (0.99–1.17) |
Kidneys | Liver | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Control | 20,5970 | 22,5839 | 19,2551 | 19,1623 | 19,9986 | 19,8560 | 23,0557 | 21,1670 | 18,6385 | 19,8489 |
20,4384 | 22,5746 | 19,0794 | 18,8645 | 19,5620 | 19,5794 | 22,9181 | 21,1984 | 18,6208 | 19,6455 | |
20,4358 | 22,5837 | 19,1140 | 18,8865 | 19,7310 | 19,9334 | 23,3011 | 21,1796 | 19,6168 | 20,4226 | |
20,5461 | 22,7381 | 19,0685 | 19,1585 | 19,7124 | 19,7203 | 23,1264 | 21,1636 | 19,4941 | 20,2836 | |
20,3772 | 22,3517 | 19,0689 | 19,2026 | 20,2427 | 19,1888 | 22,9224 | 21,0717 | 19,1761 | 19,8373 | |
20,3640 | 22,2591 | 18,9613 | 18,9177 | 19,7695 | 19,7114 | 23,1850 | 21,1812 | 19,1708 | 20,0905 | |
20,4210 | 22,1444 | 19,0667 | 18,8171 | 19,3981 | 19,8140 | 23,5071 | 21,3909 | 19,3937 | 20,2497 | |
20,5429 | 22,3808 | 19,2618 | 20,5558 | 19,7631 | 23,3798 | 21,3486 | 19,0927 | 20,2443 | ||
20,4095 | 22,3303 | 18,9823 | 20,3727 | 19,6435 | 23,5475 | 21,2771 | 19,3322 | 20,4155 | ||
19,9648 | 22,0525 | 18,7116 | 19,2846 | |||||||
AV-153-Na 0.05 mg/kg | 21,1756 | 22,9314 | 19,3199 | 19,5803 | 20,0066 | 19,3193 | 22,6985 | 21,0440 | 18,3758 | 18,9400 |
22,0513 | 23,4752 | 19,6423 | 19,9317 | 20,6172 | 18,8415 | 22,8245 | 20,9705 | 18,3795 | 19,0355 | |
21,4856 | 23,2240 | 19,4647 | 19,6623 | 19,8643 | 19,5196 | 22,7070 | 21,0585 | 18,3857 | 19,0187 | |
21,6234 | 23,2381 | 19,5993 | 19,5928 | 19,6469 | 18,8631 | 22,7883 | 20,9608 | 18,3031 | 18,9503 | |
AV-153-Na 0.5 mg/kg | 21,9367 | 23,2775 | 19,4898 | 19,8077 | 20,0014 | 19,6059 | 22,7776 | 20,9764 | 18,4171 | 19,0567 |
21,6564 | 23,2385 | 19,5634 | 19,4900 | 19,8338 | 19,6035 | 22,8215 | 21,0093 | 18,4078 | 19,0701 | |
21,2077 | 23,2004 | 19,4074 | 19,5859 | 19,9741 | 19,5527 | 22,8589 | 20,9877 | 18,3254 | 19,1177 | |
AV-153-Ca 0.05 mg/kg | 19,7019 | 22,0370 | 19,1800 | 18,7166 | 19,3175 | 19,3393 | 22,9415 | 20,8086 | 19,1408 | 19,8715 |
19,8564 | 22,2813 | 19,3695 | 18,7706 | 19,2143 | 19,6280 | 23,3113 | 21,0154 | 19,1477 | 20,3142 | |
20,1111 | 21,8349 | 19,0583 | 18,6593 | 19,3757 | 19,3697 | 22,8512 | 20,9235 | 18,9642 | 20,2187 | |
19,6506 | 23,1935 | 21,0658 | 19,3068 | 20,0824 | ||||||
AV-153-Ca 0.5 mg/kg | 20,3086 | 22,0432 | 19,5138 | 18,8374 | 19,3591 | 19,4528 | 22,9892 | 20,7577 | 19,0212 | 19,3202 |
20,5201 | 22,7760 | 18,8733 | 19,2125 | 20,2666 | 19,5880 | 23,2170 | 21,2606 | 19,0527 | 19,6300 | |
19,5801 | 21,8729 | 18,8382 | 18,7051 | 19,3437 | 18,8662 | 23,0295 | 21,3512 | 18,8270 | 19,3601 | |
20,1326 | 22,0602 | 18,9902 | 18,8147 | 19,6876 | 19,5368 | 23,2560 | 21,5740 | 19,0952 | 19,4394 | |
20,1226 | 21,8402 | 18,8235 | 18,8101 | 19,4492 | 19,5666 | 23,0126 | 21,1141 | 18,7163 | 19,2355 |