This work is licensed under the Creative Commons Attribution 4.0 International License.
Safe S. Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Crit Rev Toxicol 1984;13:319–95. doi: 10.3109/10408448409023762SafeSPolychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action1984133199510.3109/104084484090237626091997Open DOISearch in Google Scholar
Faroon OM, Samuel Keith L, Smith-Simon C, De Rosa CT; World Health Organization. Polychlorinated Biphenyls: Human Health Aspects. Concise International Chemical Assessment Document 55. Geneva: World Health Organization; 2003 [displayed 8. June 2020]. Available at https://www.who.int/ipcs/publications/cicad/en/cicad55.pdf?ua=1FaroonOMSamuel KeithLSmith-SimonCDe RosaCTWorld Health OrganizationGenevaWorld Health Organization2003[displayed 8. June 2020]. Available athttps://www.who.int/ipcs/publications/cicad/en/cicad55.pdf?ua=1Search in Google Scholar
Erickson MD, Kaley RG. Applications of polychlorinated biphenyls. Environ Sci Pollut Res Int 2011;18:135–51. doi: 10.1007/s11356-010-0392-1EricksonMDKaleyRGApplications of polychlorinated biphenyls2011181355110.1007/s11356-010-0392-120848233Open DOISearch in Google Scholar
Carpenter DO. Polychlorinated biphenyls (PCBs): routes of exposure and effects on human health. Rev Environ Health 2006;21:1–23. doi: 10.1515/reveh.2006.21.1.1CarpenterDOPolychlorinated biphenyls (PCBs): routes of exposure and effects on human health20062112310.1515/reveh.2006.21.1.116700427Open DOISearch in Google Scholar
ATSDR Agency for Toxic Substances and Disease Registry 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs) [displayed 8 June 2020]. Avalable at https://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=142&tid=26Avalable athttps://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=142&tid=26Search in Google Scholar
Banudevi S, Krishnamoorthy G, Venkataraman P, Vignesh C, Aruldhas MM, Arunakaran J. Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. Food Chem Toxicol 2006;44:2040–6. doi: 10.1016/j.fct.2006.07.017BanudeviSKrishnamoorthyGVenkataramanPVigneshCAruldhasMMArunakaranJRole of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats2006442040610.1016/j.fct.2006.07.01716979807Open DOISearch in Google Scholar
Buha A, Antonijević B, Milovanović V, Janković S, Bulat Z, Matović V. Polychlorinated biphenyls as oxidative stress inducers in liver of subacutely exposed rats: implication for dose-dependence toxicity and benchmark dose concept. Environ Res 2015;136:309–17. doi: 10.1016/j. envres.2014.11.005BuhaAAntonijevićBMilovanovićVJankovićSBulatZMatovićVPolychlorinated biphenyls as oxidative stress inducers in liver of subacutely exposed rats: implication for dose-dependence toxicity and benchmark dose concept20151363091710.1016/j.envres.2014.11.00525460651Open DOISearch in Google Scholar
Sekaran S, Kandaswamy S, Gunasekaran K, Perumal E, Afsar Basha FY, Madhan Mohan BJ, Jagadeesan A. Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats. J Biochem Mol Toxicol 2012;26:522–32. doi: 10.1002/jbt.21466SekaranSKandaswamySGunasekaranKPerumalEAfsar BashaFYMadhan MohanBJJagadeesanAProtective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats2012265223210.1002/jbt.2146623281070Open DOISearch in Google Scholar
Ruan J, Guo J, Huang Y, Mao Y, Yang Z, Zuo Z. Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. Environ Res 2020;181:108909. doi: 10.1016/j. envres.2019.108909RuanJGuoJHuangYMaoYYangZZuoZAdolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice202018110890910.1016/j.envres.2019.10890931776016Open DOISearch in Google Scholar
Aly HA, Domènech O, Abdel-Naim AB. Aroclor 1254 impairs spermatogenesis and induces oxidative stress in rat testicular mitochondria. Food Chem Toxicol 2009;47:1733–8. doi: 10.1016/j.fct.2009.03.019AlyHADomènechOAbdel-NaimABAroclor 1254 impairs spermatogenesis and induces oxidative stress in rat testicular mitochondria2009471733810.1016/j.fct.2009.03.01919306909Open DOISearch in Google Scholar
Gaschler MM, Stockwell BR. Lipid peroxidation in cell death. Biochem Biophys Res Commun 2017;482:419–25. doi: 10.1016/j.bbrc.2016.10.086GaschlerMMStockwellBRLipid peroxidation in cell death20174824192510.1016/j.bbrc.2016.10.086531940328212725Open DOISearch in Google Scholar
Zhong Y, Guo P, Wang X, An J. Aroclor 1254 inhibits cell viability and induces apoptosis of human A549 lung cancer cells by modulating the intracellular Ca(2+) level and ROS production through the mitochondrial pathway. J Environ Sci Health A Tox Hazard Subst Environ Eng 2015;50:806–13. doi: 10.1080/10934529.2015.1019797.ZhongYGuoPWangXAnJAroclor 1254 inhibits cell viability and induces apoptosis of human A549 lung cancer cells by modulating the intracellular Ca(2+) level and ROS production through the mitochondrial pathway2015508061310.1080/10934529.2015.101979726030686Open DOISearch in Google Scholar
Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation, production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014;2014:360438. doi: 10.1155/2014/360438AyalaAMuñozMFArgüellesSLipid peroxidation, production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal2014201436043810.1155/2014/360438406672224999379Open DOISearch in Google Scholar
Davies MJ. Protein oxidation and peroxidation. Biochem J 2016;473:805–25. doi: 10.1042/BJ20151227DaviesMJProtein oxidation and peroxidation20164738052510.1042/BJ20151227481957027026395Open DOISearch in Google Scholar
WHO/JECFA. Polychlorinated Biphenyls [displayed 8 June 2020]. Available at https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=1103WHO/JECFAAvailable athttps://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=1103Search in Google Scholar
Boverhof DR, Burgoon LD, Tashiro C, Sharratt B, Chittim B, Harkema JR, Mendrick DL, Zacharewski TR. Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice. Toxicol Sci 2006;94:398–416. doi: 10.1093/toxsci/kfl100BoverhofDRBurgoonLDTashiroCSharrattBChittimBHarkemaJRMendrickDLZacharewskiTRComparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice20069439841610.1093/toxsci/kfl10016960034Open DOISearch in Google Scholar
Fletcher N, Wahlström D, Lundberg R, Nilsson CB, Nilsson KC, Stockling K, Hellmold H, Håkansson H. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: a microarray study. Toxicol Appl Pharmacol 2005;207:1–24. doi: 10.1016/j.taap.2004.12.003FletcherNWahlströmDLundbergRNilssonCBNilssonKCStocklingKHellmoldHHåkanssonH2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: a microarray study200520712410.1016/j.taap.2004.12.00316054898Open DOISearch in Google Scholar
Jin MH, Ko HK, Hong CH, Han SW. In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin affects the development of reproductive system in mouse. Yonsei Med J 2008;49:843–50. doi: 10.3349/ymj.2008.49.5.843JinMHKoHKHongCHHanSW.In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin affects the development of reproductive system in mouse2008498435010.3349/ymj.2008.49.5.843261537918972606Open DOISearch in Google Scholar
Korenaga T, Fukusato T, Ohta M, Asaoka K, Murata N, Arima A, Kubota S. Long-term effects of subcutaneously injected 2,3,7,8-tetrachlorodibenzo-p-dioxin on the liver of rhesus monkeys. Chemosphere 2007;67:S399-S404. doi: 10.1016/j. chemosphere.2006.05.135KorenagaTFukusatoTOhtaMAsaokaKMurataNArimaAKubotaSLong-term effects of subcutaneously injected 2,3,7,8-tetrachlorodibenzo-p-dioxin on the liver of rhesus monkeys200767S399S40410.1016/j.chemosphere.2006.05.13517223175Open DOISearch in Google Scholar
Ohbayashi H, Sasaki T, Matsumoto M, Noguchi T, Yamazaki K, Aiso S, Nagano K, Arito H, Yamamoto S. Dose- and time-dependent effects of 2,3,7,8-tetrabromodibenzo-p-dioxin on rat liver. J Toxicol Sci 2007;32:47–56. doi: 10.2131/jts.32.47OhbayashiHSasakiTMatsumotoMNoguchiTYamazakiKAisoSNaganoKAritoHYamamotoSDose- and time-dependent effects of 2,3,7,8-tetrabromodibenzo-p-dioxin on rat liver200732475610.2131/jts.32.4717327693Open DOISearch in Google Scholar
Majumdar A, Nirwane A, Kamble R. New evidences of neurotoxicity of Aroclor 1254 in mice brain: potential of coenzyme q10 in abating the detrimental outcomes. Environ Health Toxicol 2014;10:e2014001. doi: 10.5620/eht.2014.29. e2014001MajumdarANirwaneAKambleRNew evidences of neurotoxicity of Aroclor 1254 in mice brain: potential of coenzyme q10 in abating the detrimental outcomes201410e201400110.5620/eht.2014.29.e2014001396584824683537Open DOISearch in Google Scholar
Kutlu S, Colakoglu N, Halifeoglu I, Sandal S, Seyran AD, Aydin M, Yılmaz B. Comparative evaluation of hepatotoxic and nephrotoxic effects of Aroclors 1221 and 1254 in female rats. Cell Biochem Funct 2007;25:167–72. doi: 10.1002/cbf.1289KutluSColakogluNHalifeogluISandalSSeyranADAydinMYılmazBComparative evaluation of hepatotoxic and nephrotoxic effects of Aroclors 1221 and 1254 in female rats2007251677210.1002/cbf.128916180246Open DOISearch in Google Scholar
Aydin S, Erkekoglu P, Başaran N, Kocer-Gumusel B. Impact of selenium status on Aroclor 1254-induced DNA damage in sperm and different tissues of rats. Toxicol Mech Methods 2018;28:252–61. doi: 10.1080/15376516.2017.1397234AydinSErkekogluPBaşaranNKocer-GumuselBImpact of selenium status on Aroclor 1254-induced DNA damage in sperm and different tissues of rats2018282526110.1080/15376516.2017.139723429082812Open DOISearch in Google Scholar
Erkekoglu P, Arnaud J, Rachidi W, Kocer-Gumusel B, Favier A, Hincal F. The effects of di(2-ethylhexyl) phthalate and/or selenium on trace element levels in different organs of rats. J Trace Elem Med Biol 2015;29:296–302. doi: 10.1016/j. jtemb.2014.08.002ErkekogluPArnaudJRachidiWKocer-GumuselBFavierAHincalFThe effects of di(2-ethylhexyl) phthalate and/or selenium on trace element levels in different organs of rats20152929630210.1016/j.jtemb.2014.08.00225193691Open DOISearch in Google Scholar
Duntas LH, Smyth PPA. Selenoproteins and thyroid cancer. In: Liu J, Luo G, Mu Y, editors. Selenoproteins and mimics. Berlin, Heidelberg: Springer-Verlag; 2012. p. 173–82.DuntasLHSmythPPASelenoproteins and thyroid cancerInLiuJLuoGMuYeditorsBerlin, HeidelbergSpringer-Verlag2012p1738210.1007/978-3-642-22236-8_12Search in Google Scholar
Bao RK, Zheng SF, Wang XY. Selenium protects against cadmium-induced kidney apoptosis in chickens by activating the PI3K/AKT/Bcl-2 signaling pathway. Environ Sci Pollut Res 2017;24:20342–53. doi: 10.1007/s11356-017-9422-6BaoRKZhengSFWangXYSelenium protects against cadmium-induced kidney apoptosis in chickens by activating the PI3K/AKT/Bcl-2 signaling pathway201724203425310.1007/s11356-017-9422-628707237Open DOISearch in Google Scholar
Wang X, An Y, Jiao W, Zhang Z, Han H, Gu X, Teng X. Selenium protects against lead-induced apoptosis via endoplasmic reticulum stress in chicken kidneys. Biol Trace Elem Res 2018;182:354–63. doi: 10.1007/s12011-017-1097-9WangXAnYJiaoWZhangZHanHGuXTengXSelenium protects against lead-induced apoptosis via endoplasmic reticulum stress in chicken kidneys20181823546310.1007/s12011-017-1097-928748446Open DOISearch in Google Scholar
Stadtman TC. Selenium biochemistry mammalian selenoenzymes. Ann N Y Acad Sci 2000;899:399–402. doi: 10.1111/j.1749-6632.2000.tb06203.xStadtmanTCSelenium biochemistry mammalian selenoenzymes200089939940210.1111/j.1749-6632.2000.tb06203.x10863556Open DOISearch in Google Scholar
Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005;12:1161–208. doi: 10.2174/0929867053764635ValkoMMorrisHCroninMTMetals, toxicity and oxidative stress200512116120810.2174/092986705376463515892631Open DOISearch in Google Scholar
Deneysel ve diğer bilimsel amaçlar için kullanılan hayvanların refah ve korunmasına dair yönetmelik [Regulation of the welfare and protection of animals used for experimental and other scientific purposes, in Turkish). Turkish Official Gazette 2011;28141 [displayed on 12 June 2020]. Available at http://www.resmigazete.gov.tr/eskiler/2011/12/20111213-4.htmTurkish Official Gazette 2011;28141 [displayed on 12 June 2020]. Available athttp://www.resmigazete.gov.tr/eskiler/2011/12/20111213-4.htmSearch in Google Scholar
Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes [displayed 8 June 2020]. Available at http://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32010L0063Available athttp://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32010L0063Search in Google Scholar
Erkekoglu P, Giray BK, Kizilgün M, Rachidi W, Hininger-Favier I, Roussel AM, Favier A, Hincal F. Di(2-ethylhexyl) phthalate-induced renal oxidative stress in rats and protective effect of selenium. Toxicol Mech Methods 2012;22:415–23. doi: 10.3109/15376516.2012.666652ErkekogluPGirayBKKizilgünMRachidiWHininger-FavierIRousselAMFavierAHincalFDi(2-ethylhexyl) phthalate-induced renal oxidative stress in rats and protective effect of selenium2012224152310.3109/15376516.2012.66665222394345Open DOISearch in Google Scholar
Panev A, Hauptmanova K, Pavlata L, Pechova A, Filípek J, Dvorak R. Effect of supplementation of various selenium forms and doses on selected parameters of ruminal fluid and blood in sheep. Czech J Anim Sci 2013;58:37–46. doi: 10.17221/6524-CJASPanevAHauptmanovaKPavlataLPechovaAFilípekJDvorakREffect of supplementation of various selenium forms and doses on selected parameters of ruminal fluid and blood in sheep201358374610.17221/6524-CJASOpen DOISearch in Google Scholar
Sundae RA. Chapter 8. Regulation of selenoprotein expression. In: Hatfield D, editor. Selenium: its molecular biology and role in human health. Massachusetts: Kluwer Academic Publishers; 2003. p. 81–98.SundaeRAChapter 8. Regulation of selenoprotein expressionInHatfieldDeditorMassachusettsKluwer Academic Publishers2003p8198Search in Google Scholar
Krieg RC, Dong Y, Schwamborn K, Knuechel R. Protein quantification and its tolerance for different interfering reagents using the BCA-method with regard to 2D SDS PAGE. J Biochem Biophys Methods 2005;65:13–9. doi: 10.1016/j.jbbm.2005.08.005KriegRCDongYSchwambornKKnuechelRProtein quantification and its tolerance for different interfering reagents using the BCA-method with regard to 2D SDS PAGE20056513910.1016/j.jbbm.2005.08.00516226314Open DOISearch in Google Scholar
Sedighi O, Zargari M, Varshi G. Effect of selenium supplementation on glutathione peroxidase enzyme activity in patients with chronic kidney disease: a randomized clinical trial. Nephrourol Mon 2014;6(3):e17945. doi: 10.5812/numonthly.17945SedighiOZargariMVarshiGEffect of selenium supplementation on glutathione peroxidase enzyme activity in patients with chronic kidney disease: a randomized clinical trial201463e1794510.5812/numonthly.17945409067325032143Open DOISearch in Google Scholar
Giray B, Riondel J, Richard MJ, Favier A, Hincal F. Oxidant/antioxidant status in relation to thyroid hormone metabolism in selenium- and/or iodine-deficient rats. J Trace Elem Exp Med 2004;17:109–21. doi: 10.1002/jtra.20001GirayBRiondelJRichardMJFavierAHincalFOxidant/antioxidant status in relation to thyroid hormone metabolism in selenium- and/or iodine-deficient rats2004171092110.1002/jtra.20001Open DOISearch in Google Scholar
Erkekoglu P, Chao MW, Ye W, Ge J, Trudel LJ, Skipper PL, Kocer-Gumusel B, Engelward BP, Wogan GN, Tannenbaum SR. Cytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds. Food Chem Toxicol 2014;72:98–110. doi: 10.1016/j.fct.2014.06.031ErkekogluPChaoMWYeWGeJTrudelLJSkipperPLKocer-GumuselBEngelwardBPWoganGNTannenbaumSRCytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds2014729811010.1016/j.fct.2014.06.03125014158Open DOISearch in Google Scholar
Tang W, Cheng JP, Yang YC, Wang WH. Assessing adverse effects of Aroclor 1254 on perinatally exposed rat offspring. Biomed Environ Sci 2015;28:687–90. doi: 10.3967/bes2015.097TangWChengJPYangYCWangWHAssessing adverse effects of Aroclor 1254 on perinatally exposed rat offspring2015286879010.3967/bes2015.09726464258Open DOISearch in Google Scholar
Venkataraman P, Selvakumar K, Krishnamoorthy G, Muthusami S, Rameshkumar R, Prakash S, Arunakaran J. Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats. Neurosci Res 2010;66:189–97. doi: 10.1016/j.neures.2009.10.015VenkataramanPSelvakumarKKrishnamoorthyGMuthusamiSRameshkumarRPrakashSArunakaranJEffect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats2010661899710.1016/j.neures.2009.10.01519914309Open DOISearch in Google Scholar