Association between the severity of OSAHS patients and serum PCSK9 levels
Xiaohui Zhang
- School of Medicine, Southeast UniversityNanjing, China
- Department of Cardiology, Yancheng First People’s Hospital, First Yancheng Hospital affiliated of Medical School, Nanjing UniversityYanCheng, China
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, Tiantian Ge
Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast UniversityNanjing, China
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, Songsong Song
Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast UniversityNanjing, China
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, Ming Lou
School of Medicine, Southeast UniversityNanjing, China
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and Jiayi Tong
Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast UniversityNanjing, China
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Aug 11, 2025
About this article
Article Category: Original Study
Published Online: Aug 11, 2025
Page range: 119 - 126
Received: Jul 22, 2024
Accepted: Mar 24, 2025
DOI: https://doi.org/10.2478/ahem-2025-0007
Keywords
© 2025 Xiaohui Zhang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1.
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Figure 3.
The characteristics of the participants
| Male [n (%)] | 23 (48.9) | 33 (64.7) | 28 (54.9) | 24 (72.7) | 2.16 | 0.094 |
| Age (years) | 64.5±16.48 | 66.6±13.81 | 68.5±13.58 | 63.0±14.87 | 1.14 | 0.33 |
| BMI (kg/m2) | 22.6±3.12 | 23.7±3.09 | 25.0±3.22 | 27.6±4.46 | 15.37 | 0.001 |
| Smoking [n (%)] | 14 (29.79) | 20 (39.22) | 22 (43.14) | 21 (63.64) | 3.18 | 0.025 |
| Hypertension [n (%)] | 5 (10.64) | 10 (19.61) | 11 (21.57) | 8 (24.24) | 1.14 | 0.33 |
| Hyperlipidemia [n (%)] | 26 (55.32) | 33 (64.71) | 29 (56.86) | 24 (72.73) | 1.06 | 0.37 |
| Diabetes [n (%)] | 12 (25.53) | 17 (33.33) | 14 (27.45) | 17 (51.52) | 2.21 | 0.089 |
| Atrial fibrillation [n (%)] | 12 (25.53) | 10 (19.61) | 24 (47.06) | 18 (54.55) | 6.31 | 0.001 |
| Coronary heart disease [n (%)] | 21 (44.68) | 24 (47.06) | 25 (49.02) | 16 (48.48) | 0.07 | 0.98 |
| Renal insufficiency [n (%)] | 6 (12.77) | 6 (11.76) | 6 (11.76) | 8 (24.24) | 0.28 | 0.84 |
| Heart failure [n (%)] | 11 (23.4) | 10 (19.61) | 30 (58.82) | 14 (42.42) | 0.36 | 0.09 |
| LDL-C (mmol/l) | 2.4±0.76 | 2.2±0.90 | 2.7±1.13 | 2.8±0.98 | 0.61 | 0.61 |
| HDL-C (mmol/l) | 1.2±0.32 | 1.2±0.34 | 1.1±0.30 | 1.1±0.24 | 3.17 | 0.26 |
| TC (mmol/l) | 3.9±1.18 | 3.8±1.11 | 4.9±1.54 | 4.7±1.51 | 5.4 | 0.001 |
| TG (mmol/l) | 1.2±0.77 | 1.3±0.60 | 1.6±0.95 | 1.7±1.50 | 2.94 | 0.035 |
| Lpa (mg/l) | 1.1±0.22 | 1.1±0.20 | 1.1±0.20 | 1.0±0.20 | 0.9 | 0.44 |
| Apoprotein A (mg/l) | 0.74±0.26 | 0.69±0.24 | 0.78±0.34 | 0.74±0.24 | 0.99 | 0.4 |
| Apoprotein B (mg/l) | 223.6±237.78 | 227.3±185.53 | 333.0±262.85 | 335.6±199.48 | 3.49 | 0.017 |
| Glycosylated hemolobin (%) | 6.19±1.32 | 6.28±1.21 | 6.41±1.19 | 6.86±1.56 | 1.82 | 0.15 |
| Uric acid (umol/l) | 400.4±126.98 | 428.5±133.29 | 434.1±127.14 | 451.2±123.32 | 1.12 | 0.34 |
| PCSK9 (ng/ml) | 23.9±24.93 | 61.2±36.80 | 149.2±94.73 | 274.7±61.72 | 128 | 0.001 |
The association between different degrees of OSAHS and PCSK9 levels
| Varuables | Crude Model | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
| 95% CI | P-value | 95% CI | P-value | 95% CI | P-value | |
| OSAS | ||||||
| No | Reference | Reference | Reference | |||
| Mild | 1.051(1.028–1.076) | <0.001 | 1.051(1.028–1.077) | <0.001 | 1.051(1.027–1.078) | <0.001 |
| Moderate | 1.065(1.042–1.093) | <0.001 | 1.066(1.042–1.094) | <0.001 | 1.062(1.037–1.090) | <0.001 |
| Severe | 1.083(1.060–1.114) | <0.001 | 1.083(1.060–1.115) | <0.001 | 1.080(1.055–1.113) | <0.001 |