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Orexin receptor blockers: A tool for lowering alcohol intake and alcohol addictive behavior in the light of preclinical studies

Kamila Czora-Poczwardowska
Kamila Czora-Poczwardowska
, 
Radosław Kujawski
Radosław Kujawski
, 
Julia Słyńko-Krzyżostaniak
Julia Słyńko-Krzyżostaniak
, 
Przemysław Ł. Mikołajczak
Przemysław Ł. Mikołajczak
 and 
Michał Szulc
Michał Szulc
   | Dec 29, 2021
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Article Category: Review
Published Online: Dec 29, 2021
Page range: 959 - 969
Received: Aug 16, 2020
Accepted: Apr 16, 2021
DOI: https://doi.org/10.2478/ahem-2021-0007
Keywords
© 2021 Kamila Czora-Poczwardowska., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Summary of behavioral preclinical experiments using antagonists of OXR along with a brief description of some experimental details

Antagonist In vitro study (Cellular measurements) In vivo (Proven action) Procedure Dose/Administration Effect specificity Author’s
SB-334867 N/l + P female rat 2-bottle choice 3, 10, or 30 mg/kg, i.p. N/l [4]
N/l - P female rat Operant progressive ratio N/l
N/l + Male C57BL/6 mice Binge drinking -
SB-334867 + + All procedures 15%EtOH Male C57BL/6 mice Binge drinking 20%EtOH 5 mg/kg, i.p. N/l [48]
SB-334867 N/l + Male P rat Operant progressive ratio 10%EtOH 3 μg VTA + [61]
SB-334867 N/l + Female P rat Operant progressive ratio for EtOH->PSR ->Relapse ->SB administration>PSR ->Relapse 15%EtOH 10 or 20 mg/kg, i.p. N/l [59]
SB-334867 + + Male P rat Operant progressive ratio 10%EtOH 5 or 10 mg/kg i.p. + [57]
SB-334867 + + Male C57BL/6 mice 2-bottle choice 15%EtOH 0.3, 1, 3 or 10 mg/kg i.p. + [49]
SB-334867 + mNAsh + mPFC + Male C57BL/6 mice Binge drinking 15%EtOH 3 μg mNAsh and mPFC + [50]
+ Male Long Evans rat Operant progressive ratio 20%EtOH N/l
SB-334867 + + Male P rat Operant responding ratio 10%EtOH 20 mg/kg, i.p. + [58]
GSK1059865 + + Male C57BL/6 mice intermittent ethanol or air exposure in inhalation chambers 15%EtOH 10, 25, 50 mg/kg i.p + [60]
SB-334867 N/l + Male Wistar rat 2-bottle choice 10%EtOH 3 ng, 6 ng NAcc - [44]
SB-334867 N/l + Male Sprague Dawley rat 2-bottle choice 10%EtOH 30 mg/kg, i.p. + [46]
SB-334867 N/l + Male Sprague-Dawley rat Operant progressive ratio cue-induced reinstatement 10, or 20 mg/kg i.p. + [47]
+ 20%EtOH
SB-334867 + + Male C57BL/6 mice Binge drinking 20%EtOH 5 or 10 mg/kg, i.p. - [51]
SB-334867 + + Male C57BL/6 mice Binge drinking 20%EtOH 6.0 pg VTA and CeA + [55]
SB-334867 - + Male Long-Evans rat Operant progressive ratio 10%EtOH 5, 10, 15, 20 mg/kg, i.p. + [43]
SB-408124 + - Male DBA/2 mice CPP 3, 10, 30 mg/kg, s.c. N/l [45]
- Male Wistar rat Operant progressive ratio
All procedures 8%EtOH
SB-334867 + - Male DBA/2J mice CPP 10, 15, 20, 30, 40 mg/kg, i.p. N/l [52]
20%EtOH
LSN2424100 N/l - P female rat 2-bottle choice 10 or 30 mg/kg, i.p. N/l [4]
N/l + P female rat Operant progressive ratio 3, 10, 30 mg/kg i.p N/l
N/l + Male C57BL/6 mice Binge drinking 5, 30, 60 mg/kg i.p -
All procedures 15%EtOH
TCS-OX2-29 + aPVT + pPVT- Male Long-Evans rat 2-bottle-choice 20%EtOH 10 nmol aPVT, pPVT aPVT + pPVT- [42]
TCS-OX2-29 + NAcc + NAcsh - Male P rats cue-induced reinstatement of ethanol-seeking 100 μg or 300 μg NAcsh or NAcc + [56]
+ Operant responding ratio 10%EtOH
TCS-OX2-29 + Male C57BL/6 mice 2-bottle choice 15%EtOH 3 or 10 mg/kg i.p N/l [49]
TCS-OX2-29 + Male C57BL/6 mice Binge drinking 15%EtOH 3 μg mNAsh N/l [50]
- Operant progressive ratio 20%EtOH N/l
TCS-OX2-29 + Male C57BL/6 mice Binge drinking 20%EtOH 5.0, or 7.5 μg VTA, CeA - [55]
JNJ10397049 + - Male DBA/2 mice CPP 1, 3, and 10 mg/kg, s.c. + [45]
+ Male Wistar rat Operant progressive ratio
All procedures 8%EtOH
Almorexant N/l + P female rat 2-bottle choice 60 or 100 mg/kg, i.p. N/l [4]
+ P female rat Operant progressive ratio 10, 30, or 60 mg/kg, i.p. N/l
+ Male C57BL/6 mice Binge drinking 5, 50, or 100 mg/kg, i.p. -
All procedures 15%EtOH
Almorexant + VTA + SN - Male Long-Evans rat Operant progressive ratio 20%EtOH 3, 10 and 15 mg/kg, i.p. VTA and SN - [62]
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Life Sciences, Molecular Biology, Microbiology and Virology, Medicine, Basic Medical Science, Immunology
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