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European Pharmaceutical Journal
Volume 70 (2023): Issue s1 (December 2023)
Open Access
A Multiple Unit Abuse-deterrent Dosage Form Based on Sodium Alginate
M. Papadakos
M. Papadakos
,
M. Špaglová
M. Špaglová
,
M. Čuchorová
M. Čuchorová
and
M. Hanko
M. Hanko
| Sep 15, 2023
European Pharmaceutical Journal
Volume 70 (2023): Issue s1 (December 2023)
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Article Category:
Special issue article
Published Online:
Sep 15, 2023
Page range:
75 - 79
Received:
Apr 14, 2018
Accepted:
Jun 01, 2018
DOI:
https://doi.org/10.2478/afpuc-2023-0020
Keywords
Multiple unit dosage form
,
Abuse deterrent dosage form
,
Microcapsules
,
Microbeads
,
Sodium alginate
© 2023 M. Papadakos et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1.
Hot dried Ca2+-alginate microcapsules at 77× and 100× magnification.
Figure 2.
Ca2+-alginate microcapsules taken after 24 h in artificial intestinal fluid pH 6.8 (a1 – hot dried, a2 – freeze-dried), artificial gastric fluid pH 1.2 (b1 – hot dried, b2 – freeze-dried), and artificial gastric fluid with ethanol 40% (w/w) (c1 – hot dried, c2 – freeze-dried)
Figure 3.
The swelling ability of Ca2+-alginate microcapsules in artificial gastric fluid (pH 1.2), artificial gastric fluid with 40% (w/w) ethanol (pH 1.2 + EtOH), and artificial intestinal fluid (pH 6.8).