<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>AIM</h3>
<p>The aim of the study was to evaluate cardiovascular risk in patients with diabetes mellitus type 2 according to gender.</p>
</sec>
<sec><h3>METHODS</h3>
<p>The monitoring was designed as a retrospective analysis of data obtained from the documentation of the diabetic outpatients treated with the dipeptidyl peptidase-4 inhibitors (DPP4is) or sodium–glucose co-transporter-2 (SGLT2). Cardiovascular risk was assessed according to UKPDS risk engine.</p>
</sec>
<sec><h3>RESULTS</h3>
<p>The levels of HbA1c decreased throughout the whole study. Sixty per cent of patients achieved an HbA1c level &lt;8% after 18 months. Both men and women had similar glycaemic compensation. Men had a significantly higher risk of fatal coronary heart disease (CHD) (<italic>p</italic> &lt; 0.001), stroke (<italic>p</italic> &lt; 0.01) and fatal stroke (<italic>p</italic> &lt; 0.01) compared to women. We found the risk of fatal CHD to be 38-fold higher in men compared to women (<italic>p</italic> &lt; 0.01).</p>
</sec>
<sec><h3>CONCLUSION</h3>
<p>Potential cardiovascular effects of antidiabetic treatment should be clearly defined with possible different effects according to gender. We found a much higher risk in men than women, even when their glycaemic compensation was comparable.</p>
</sec>
</abstract>

AIM
The aim of the study was to evaluate cardiovascular risk in patients with diabetes mellitus type 2 according to gender.

METHODS
The monitoring was designed as a retrospective analysis of data obtained from the documentation of the diabetic outpatients treated with the dipeptidyl peptidase-4 inhibitors (DPP4is) or sodium–glucose co-transporter-2 (SGLT2). Cardiovascular risk was assessed according to UKPDS risk engine.

RESULTS
The levels of HbA1c decreased throughout the whole study. Sixty per cent of patients achieved an HbA1c level <8% after 18 months. Both men and women had similar glycaemic compensation. Men had a significantly higher risk of fatal coronary heart disease (CHD) (p < 0.001), stroke (p < 0.01) and fatal stroke (p < 0.01) compared to women. We found the risk of fatal CHD to be 38-fold higher in men compared to women (p < 0.01).

CONCLUSION
Potential cardiovascular effects of antidiabetic treatment should be clearly defined with possible different effects according to gender. We found a much higher risk in men than women, even when their glycaemic compensation was comparable.

The Evaluation of Cardiovascular Risk in Diabetic Patients

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The Evaluation of Cardiovascular Risk in Diabetic Patients"}

AIM
The aim of the study was to evaluate cardiovascular risk in patients with diabetes mellitus type 2 according to gender.

METHODS
The monitoring was...

CVD risk	Women mean (%) ± SEM (min.–max. %)	Men mean (%) ± SEM (min.–max. %)	M vs. W p <
V1 CHD	16.58 ± 0.89 (3.10–54.90)	30.61 ± 1.87 (4.10–75.80)	0.001
V2 CHD	17.17 ± 1.03 (1.40–63.60)	30.94 ± 1.75 (5.00–70.90)	0.001
V1 fatal CHD	12.49 ± 0.84 (1.50–49.30)	23.33 ± 1.76 (1.10–66.50)	0.001
V2 fatal CHD	13.38 ± 0.98 (0.50–60.50)	24.05 ± 1.70 (1.50–65.70)	0.001
V1 stroke	9.76 ± 0.88 (1.00–55.80)	15.99 ± 1.94 (0.90–89.20)	0.01
V2 stroke	11.91 ± 1.00 (1.10–58.60)	19.23 ± 2.07 (0.80–92.90)	0.01
V1 fatal stroke	1.71 ± 0.17 (0.20–10.30)	2.98 ± 0.41 (0.10–21.40)	0.01
V2 fatal stroke	2.00 ± 0.19 (0.10–11.30)	3.44 ± 0.38 (0.10–16.80)	0.01

The Evaluation of Cardiovascular Risk in Diabetic Patients

Article Category: Original Paper

Published Online: Apr 04, 2022

Page range: 1 - 8

Received: Aug 06, 2021

Accepted: Nov 05, 2021

DOI: https://doi.org/10.2478/afpuc-2022-0001

Keywords
diabetes, UKPDS, coronary heart disease, stroke, gender

© 2022 S. Kosirova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Figure 2

Figure 3

The cardiovascular risk according to UKPDS risk engine in men and women.

The Evaluation of Cardiovascular Risk in Diabetic Patients

Article Category: Original Paper

Published Online: Apr 04, 2022

Page range: 1 - 8

Received: Aug 06, 2021

Accepted: Nov 05, 2021

DOI: https://doi.org/10.2478/afpuc-2022-0001

Keywordsdiabetes, UKPDS, coronary heart disease, stroke, gender

© 2022 S. Kosirova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Figure 2

Figure 3

The cardiovascular risk according to UKPDS risk engine in men and women.

Keywords
diabetes, UKPDS, coronary heart disease, stroke, gender