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Chitosan Hydrogel Improves Bioavailability of Megosin

E. M. Sultanova

E. M. Sultanova

Laboratory of Proteins and Peptides Chemistry, Institute of Bioorganic chemistry, Academy of Sciences of UzbekistanTashkent, Uzbekistan
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Sultanova, E. M.
, 
M. K. Salakhutdinova

M. K. Salakhutdinova

Laboratory of Proteins and Peptides Chemistry, Institute of Bioorganic chemistry, Academy of Sciences of UzbekistanTashkent, Uzbekistan
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Salakhutdinova, M. K.
, 
Y. I. Oshchepkova

Y. I. Oshchepkova

Laboratory of Proteins and Peptides Chemistry, Institute of Bioorganic chemistry, Academy of Sciences of UzbekistanTashkent, Uzbekistan
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Oshchepkova, Y. I.
, 
A. M. Asrorov

A. M. Asrorov

  • Laboratory of Proteins and Peptides Chemistry, Institute of Bioorganic chemistry, Academy of Sciences of UzbekistanTashkent, Uzbekistan
  • State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesChina
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Asrorov, A. M.
, 
M. J. Oripova

M. J. Oripova

Laboratory of Proteins and Peptides Chemistry, Institute of Bioorganic chemistry, Academy of Sciences of UzbekistanTashkent, Uzbekistan
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Oripova, M. J.
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U. J. Ishimov

U. J. Ishimov

Laboratory of Proteins and Peptides Chemistry, Institute of Bioorganic chemistry, Academy of Sciences of UzbekistanTashkent, Uzbekistan
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Ishimov, U. J.
 and 
S. I. Salikhov

S. I. Salikhov

Laboratory of Proteins and Peptides Chemistry, Institute of Bioorganic chemistry, Academy of Sciences of UzbekistanTashkent, Uzbekistan
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Salikhov, S. I.
  
Nov 18, 2020
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Article Category: Original Paper
Published Online: Nov 18, 2020
Page range: 1 - 6
Received: May 10, 2019
Accepted: Jan 14, 2020
DOI: https://doi.org/10.2478/afpuc-2020-0006
Keywords
© 2019 Sultanova E. M. et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Structure of megosin
Structure of megosin

Figure 2

Kinetics of megosin release from 4% chitosan gel samples
Kinetics of megosin release from 4% chitosan gel samples

Figure 3

HPLC analysis of megosin in 4% chitosan gel cross-linked with 1.4% STPP
HPLC analysis of megosin in 4% chitosan gel cross-linked with 1.4% STPP

Figure 4

Infrared spectra of chitosan (A), megosin (B), and the dried gel sample on their bases (C)
Infrared spectra of chitosan (A), megosin (B), and the dried gel sample on their bases (C)

Releasing level of megosin from chitosan hydrogels

Gel compositionRelease percentage of megosin from the gel for 7 h
Chitosan (%)Megosin (mg)STPP (%)
211.420.73 ± 2.33
221.425.88 ± 1.11
212.846.72 ± 2.58
222.832.93 ± 0.89
41059.89 ± 1.80
411.451.62 ± 1.68
412.844.91 ± 1.44
415.611.96 ± 0.69
51011.07 ± 2.13
511.46.71 ± 0.667
Language:
English
Publication timeframe:
2 times per year
Journal Subjects:
Pharmacy, Pharmacy, other
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