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Antinociceptive Effect of P-Cymene and Cinnamaldehyde: Their Relationship with the L-Arginine-Nitric Oxide Pathway in Rats

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Jun 16, 2025

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Assis DB, Aragão Neto HC, da Fonsêca DV, de Andrade HHN, Braga RM, Badr N, Maia MDS, Castro RD, Scotti L, Scotti MT, de Almeida RN: Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review Front Pharmacol 2020, 11,777. Search in Google Scholar

Tomanić D, Božin B, Čabarkapa I, Kladar N, Radinović M, Maletić M, Kovačević Z: Chemical composition, antioxidant and antibacterial activity of two different essential oils against mastitis associated pathogen. Acta Vet-Beograd 2022, 72(1):45-58. Search in Google Scholar

Ebani VV, Mancianti F: Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections. Vet Sci 2020, 7(4):193. Search in Google Scholar

Đorđe S. Marjanović SĐ, Zdravković N, Milovanović M, Nedeljković Trailović J, Robertson PA, Todorović Z, Trailović MS: Carvacrol acts as a potent selective antagonist of different types of nicotinic acetylcholine receptors and enhances the effect of monepantel in the parasitic nematode Ascaris suum. Vet Parasitol 2020, 278:109031. Search in Google Scholar

Tambur Z, Žižak Besu I, Žižak Ž, Joksić A, Opačić D, Biočanin V: Antiproliferative effect of Spilanthes acmella extracts on human cervix adenocarcinoma and human myelogenous leukemia cells. Acta Vet-Beograd 2024, 74(4):538-545. Search in Google Scholar

Eder JL, Lucielli S, Raquel GJ, Francine NV, Débora MM: Antinociceptive Effect of Essential Oils and Their Constituents: an Update Review. J Braz Chem Soc 2016, 27(3): 435-474. Search in Google Scholar

Bezerra AJN, Silva FCO, da Silva AW, Ferreira MKA, Marinho EM, Marinho MM, Magalhães FEA, Bandeira PN, Rodrigues Teixeira AM, Marinho ES, de Menezes JESA, Dos Santos HS: Antinociceptive effect of triterpene acetyl aleuritolic acid isolated from Croton zehntneri in adult zebrafish (Danio rerio). Biochem Biophys Res Commun 2021, 534:478-484. Search in Google Scholar

Gouveia DN, Costa JS, Oliveira MA, Rabelo TK, Silva AMOE, Carvalho AA, Miguel-Dos-Santos R, Lauton-Santos S, Scotti L, Scotti MT, Santos MRVD, Quintans-Júnior LJ, Albuquerque Junior RLC, Guimarães AG: α-Terpineol reduces cancer pain via modulation of oxidative stress and inhibition of iNOS. Biomed Pharmacother 2018, 105:652-661. Search in Google Scholar

Niu CS, Li Y, Liu YB, Ma SG, Wang XJ, Liu F, Liu S, Qu J, Yu SS: Diverse epoxy grayanane diterpenoids with analgesic activity from the roots of Pieris formosa. Fitoterapia 2019, 133:29-34. Search in Google Scholar

De Cássia da Silveira e Sá R, Lima TC, da Nóbrega FR, de Brito AEM, de Sousa DP: Analgesic-like activity of essential oil constituents: An update. Int J Mol Sci 2017, 18:2392. Search in Google Scholar

de Oliveira TM, de Carvalho RB, da Costa IH, de Oliveira GA, de Souza AA, de Lima SG, de Freitas RM: Evaluation of p-cymene, a natural antioxidant. Pharm Biol 2015, 53(3):423-8. Search in Google Scholar

Rao PV, Gan SH: Cinnamon: a multifaceted medicinal plant. Evid Based Complement Alternat Med 2014:642942. Search in Google Scholar

Yu C, Li YL, Liang M, Dai SY, Ma L, Li WGLai F, Liu XM: Characteristics and hazards of the cinnamaldehyde oxidation process. RSC Adv 2020, 10(32):19124-19133. Search in Google Scholar

Santana MF, Quintans-Júnior LJ, Cavalcanti CH, Oliveira mgB, Guimaraes AG, Cunha ES, Melo MS, Santos MRV, Araújo AAS, Bonjardim LR: p-Cymene reduces orofacial nociceptive response in mice. Brazil J Pharmacog 2011, 21(6):1138-1143. Search in Google Scholar

Santana MF, Guimaraes AG, Chaves DO, Silva JC, Bonjardim LR, de Lucca Júnior W, de Ferro JN, Barreto EO, dos Santos FE, Soares, MB. Villarreal CF, Quintas S, Quintas Junior L: The anti-hyperalgesic and anti-inflammatory profiles of p-cymene: Evidence for the involvement of opioid system and cytokines. Pharm Biol 2015, 53:1583–1590. Search in Google Scholar

Taylor JC, Dewberry LS, Totsch SK, Yessick LR, DeBerry JJ, Watts SA, Sorge RE: A novel zebrafish-based nociception model. Physiol Behav 2017, 174:83-88. Search in Google Scholar

Pigatto GR, Silva CS, Parizotto NA: Photobiomodulation therapy reduces acute pain and inflammation in mice. J Photochem Photobiol B 2019, 196:111513. Search in Google Scholar

Ghardashpour M, Saeedi M, Negarandeh R, Enderami ES, Ghorbani A, Lotfzadeh A, Jafari A, Arezoumandi A, Hassannia H, Molania T: Anti-inflammatory and tissue repair effect of cinnamaldehyde and nano cinnamaldehyde on gingival fibroblasts and macrophages. BMC Oral Health 2023, 23:1014. Search in Google Scholar

Guo J, Yan S, Jiang X, Su Z, Zhang F, Xie J, Hao E, Yao C: Advances in pharmacological effects and mechanism of action of cinnamaldehyde. Front Pharmacol 2024, 15:1365949. Search in Google Scholar

Chao Ma: Animal Models of Pain. Int Anesthesiol Clin 2007, 45(2):121-131. Search in Google Scholar

Patil KR, Mahajan UB, Unger BS, Goyal SN, Belemkar S, Surana SJ, Ojha S, Patil CR: Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals. Int J Mol Sci 2019, 20(18):4367. Search in Google Scholar

Carvalho IO, Queiroz CVG, Marques GFO, Craveiro RMCB, Xavier Júnior FAF, Gouveia Júnior FS, Lopes LGF, Chaves EMC, Monteiro HAS, Assreuy AMS, Evangelista JSAM: The nitric oxide pathway is involved in the anti-inflammatory effect of the rutheniumcomplex [Ru(bpy)2(2-MIM) (NO)] (PF6)3. Eur J Pharmacol 2022, 921:174869. Search in Google Scholar

Мilovanović M, Vučković S, Prostran M, Trailović S, Jovanović M: L-arginine-NO system participates in the analgesic effect of flunixin meglumine in the rat. Acta Vet-Beograd 2016, 66(1):103-114. Search in Google Scholar

Sachs D, Cunha FQ, Ferreira SH: Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci USA 2004, 101(10):3680-5. Search in Google Scholar

Barbosa AL, Pinheiro CA, Oliveira GJ, Torres JN, Moraes MO, Ribeiro RA, Vale ML, Souza MH: Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by walker tumor bearing in rats. Braz J Med Biol Res 2012, 45(6):531-6. Search in Google Scholar

Milovanović M, Milosavljević M, Marjanović Đ, Trailović MS, Vučinić M, Nedeljković Trailović J, Marković M, Durđević D: The effect of carvacrol on inflammatory pain and motor coordination in rats. Acta Vet-Beograd 2016, 66(4):478-488. Search in Google Scholar

Vivancos GG, Verri Jr WA, Cunha TM, Schivo IRS, Parada CA, Cunha FQ, Ferreira SH: An electronic pressure-meter nociception paw test for rats. Braz J Med Biol Res 2004, 37(3):391-399. Search in Google Scholar

Quintans SSJ, Menezes PP, Santos MR, Bonjardim LR, Almeida JR, Gelain DP, Araújo AA, Quintans-Júnior LJ: Improvement of p-cymene antinociceptive and anti-inflammatory effects by inclusion in ß-cyclodextrin. Phytomedicine 2013, 20:436-440. Search in Google Scholar

Quintans-Júnior L, Moreira JC, Pasquali MA, Rabie SM, Pires AS, Schröder R, Rabelo TK, Santos JP, Lima PS, Cavalcanti SC, Araújo AA, Quintans JS, Gelain DP: Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models. ISRN Toxicology 2013, ID 459530. Search in Google Scholar

Molania T, Malekzadeh Shafaroudi A, Saeedi M, Moosazadeh M, Valipour F, Rostamkalaei SS, Salehabadi N, Salehi M: Evaluation of cinnamaldehyde mucoadhesive patches on minor recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled clinical trial. BMC Oral Health 2022, 22(1):235. Search in Google Scholar

Molania T, Moghadamnia AA, Pouramir M, Aghel S, Moslemi D, Ghassemi L, Motallebnejad M: The effect of Cinnamaldehyde on mucositis and salivary antioxidant capacity in gamma-irradiated rats (a preliminary study). DARU J Pharmac Sci 2012, 20(1):89. Search in Google Scholar

Christopherson SK, Bredt SD: Nitric oxide in excitable tissues: physiological roles and disease. J Clin Invest 1997, 100(10):2424-2429. Search in Google Scholar

Tao F, Tao YX, Mao P, Zhao C, Li D, Liaw WJ, Raja SN, Johns RA: Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neurosci 2003, 120(3):847-54. Search in Google Scholar

Azevedo Ade O, Campos JJ, de Souza GG, Veloso Cde C, Duarte ID, Braga FC, Perez Ade C: Antinociceptive and anti-inflammatory effects of myricetin 3-O-β-galactoside isolated from Davilla elliptica: involvement of the nitrergic system. J Nat Med 2015, 69(4):487-93. Search in Google Scholar

Abacioğlu N, Tunçtan B, Akbulut E, Cakici I: Participation of the L-arginine-NO-cGMP cascade by chemically induced abdominal constriction in the mouse. Life Sci 2000, 67:1127-1137. Search in Google Scholar

Mansouri MT, Naghizadeh B, Ghorbanzadeh B, Alboghobeish S, Houshmand G, Amirgholami N: Venlafaxine Attenuates the Development of Morphine Tolerance and Dependence: Role of L-Arginine/Nitric Oxide/cGMP Pathway. Endocr Metab Immune Disord Drug Targets 2018, 18(4):362-370. Search in Google Scholar

Safaripour S, Nemati Y, Parvardeh S, Ghafghazi S, Fouladzadeh A, Moghimi M: Role of L-arginine/SNAP/NO/cGMP/KATP channel signalling pathway in the antinociceptive effect of a-terpineol in mice. J Pharm Pharmacol 2018, 70(4):507-515. Search in Google Scholar

Hernandez-Leon A, González-Trujano ME, Narváez-González F, Pérez-Ortega G, Rivero-Cruz F, Aguilar MI: Role of ß-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil. Molecules 2020, 25:675. Search in Google Scholar

Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Veterinary Medicine