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Pharmacokinetics and Bioavailability of Doxycycline Following Parenteral Administration in Rabbits

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Mar 18, 2025

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Cullere M, Zotte AD: Rabbit meat production and consumption: State of knowledge and future perspectives. Meat Sci 2018, 143: 137–146. Search in Google Scholar

Přibylová L, Součková M, Kolářová MF, Vostrá–Vydrová H, Chaloupková, H: Does a stronger bond with pet rabbits equate to better husbandry conditions for them? Applied Anim Behav Sci 2024, 270: 106143. Search in Google Scholar

Rougier S, Galland D, Boucher S, Boussarie D, Vallé M: Epidemiology and susceptibility of pathogenic bacteria responsible for upper respiratory tract infections in pet rabbits. Vet Microbiol 2006, 115: 192–198. Search in Google Scholar

Varga M: Infectious diseases of domestic rabbits. In Varga, M. (Ed.), Textbook of Rabbit Medicine (2nd ed.). Oxford, UK: Butterworth–Heinemann; 2013, 137–177, 435–471. Search in Google Scholar

Gleeson M, Petritz OA: Emerging Infectious Diseases of Rabbits. Vet Clin North Am Exot Anim Pract 2020, 23(2): 249–261. Search in Google Scholar

Zhao X, Yang J, Ju Z, Chang W, Sun S: Molecular characterization of antimicrobial resistance in Escherichia coli from rabbit farms in Tai’an, China. BioMed Res Int 2018, 2018: 8607647. Search in Google Scholar

Wang J, Sun S, Chen Y, Chen D, Sang L, Xie X: Characterisation of Bordetella bronchiseptica isolated from rabbits in Fujian, China. Epidemiol Infect 2020, 148: e237. Search in Google Scholar

Simonová M, Fotta M, Lauková A: Characteristics of Staphylococcus aureus isolated from rabbits. Folia Microbiol 2007, 52: 291–296. Search in Google Scholar

Quesenberry K, Mans C, Orcutt C: Ferrets, Rabbits and Rodents. In J.W. Carpenter (Ed), Clinical Medicine and Surgery. 2004. Search in Google Scholar

Morris TH: Antibiotic therapeutics in laboratory animals. Lab Anim 1995, 29: 16–36. Search in Google Scholar

EMA: Categorisation of Antibiotics in the European Union. Answer to the Request from the European Commission for Updating the Scientific Advice on the Impact on Public Health and Animal Health of the Use of Antibiotics in Animals. 2020. https://www.ema.europa.eu/en/documents/report/categorisation–antibiotics–european–union–answer–request–european–commission–updating–scientific–advice–impact–public–health–and–animal–health–use–antibiotics–animals_en.pdf Search in Google Scholar

Mileva R, Milanova A: Doxycicline pharmacokinetics in mammalian species of veterinary interest – an overview. Bulg J of Vet Med 2022, 25(1): 1–20. Search in Google Scholar

Mitić SS, Miletić GŽ, Kostić DA, Nasković–Ðokić DČ, Arsić BB, Rašić ID: A rapid and reliable determination of doxycycline hyclate by HPLC with UV detection in pharmaceutical samples. J Chem Soc 2008, 73: 665–671. Search in Google Scholar

Abd El–Aty AM, Goudah A, Zhou HH: Pharmacokinetics of doxycycline after administration as a single intravenous bolus and intramuscular doses to non–lactating Egyptian goats. Pharm Res 2004, 49: 487–491. Search in Google Scholar

Castro LJ, Sahagún AM, Diez MJ, Fernández N, Sierra M, García JJ: Pharmacokinetics of doxycycline in sheep after intravenous and oral administration. The Vet J 2009, 180: 389–395. Search in Google Scholar

Castro LJ, Sahagún AM, Diez MJ, Fernández N, Sierra M, García JJ: Pharmacokinetic behavior of doxycycline after intramuscular injection in sheep. Am J Vet Res 2012, 73: 714–718. Search in Google Scholar

Chapuis RJJ, Smith JS, French HM, Toka FN, Peterson EW, Little EL: Nonlinear mixed– effect pharmacokinetic modeling and distribution of doxycycline in healthy female donkeys after multiple intragastric dosing–preliminary investigation. Animals 2021, 11: 2047. Search in Google Scholar

Gutiérrez L, Ocampo L, Espinosa F, Sumano H: Pharmacokinetics of an injectable long– acting parenteral formulation of doxycycline hyclate in pigs. J Vet Pharmacol Ther 2014, 37: 83–89. Search in Google Scholar

Martínez J, Escudero E, Badillo E, Yuste MT, Galecio JS, Marín P: Pharmacokinetics of Doxycycline in Plasma and Milk after Intravenous and Intramuscular Administration in Dairy Goats. Animals 2024a, 14: 2416. Search in Google Scholar

Martínez J, Escudero E, Badillo E, Yuste MT, Galecio, JS, Marín P: Disposition kinetics and bioavailability of doxycycline after parenteral administrations in ewes. Res Vet Sci 2024b, 180: 105412. Search in Google Scholar

Meijer LA, Ceyssens KGF, de Greve BIJA, de Bruijn W: Pharmacokinetics and bioavailability of doxycycline hyclate after oral administration in calves. Vet Quart 1993, 15: 1–5. Search in Google Scholar

Mileva R, Rusenov A, Milanova A: Population pharmacokinetic modelling of orally administered doxycycline to rabbits at different ages. Antibiotics 2021, 10(3): 310. Search in Google Scholar

Vargas–Estrada D, Gracia–Mora J, Sumano H: Pharmacokinetic study of an injectable long–acting parenteral formulation of doxycycline hyclate in calves. Res Vet Sci 2008, 84: 477–482. Search in Google Scholar

Vargas D, Gutierrez L, Juárez I, Gonzalez F, Sumano H: Pharmacokinetics after administration of an injectable experimental long–acting parenteral formulation of doxycycline hyclate in goats. Am J Vet Res 2008, 69: 1085–1090. Search in Google Scholar

Turk E, Corum O, Tekeli IO, Sakin F, Uney K: Effects of single and repeated doses on disposition and kinetics of doxycycline hyclate in goats. Animals 2020, 10: 1088. Search in Google Scholar

Zozaya H, Gutierrez L, Bernad MJ, Sumano H: Pharmacokinetics of a peroral single dose of two long–acting formulations and an aqueous formulation of doxycycline hyclate in horses. Acta Vet Scand 2013, 55: 21. Search in Google Scholar

Christ AP, Trindade P, Lino R, Bitencourt A, Sonego E, Horn AI: Development of doxycycline hyclate suppositories and pharmacokinetic study in rabbits. Eur J of Pharm Sci 2020, 142: 105141. Search in Google Scholar

Fu H, Zhang L, Zhang W: Preparation of doxycycline hyclate microcapsule and its pharmacokinetic in rabbit. Acta Vet Zootech Sin 2011, 42: 1438–1444. Search in Google Scholar

Kylie J, McEwen SA, Boerlin, P, Reid–Smith RJ, Weese JS, Turner PV: Prevalence of antimicrobial resistance in fecal Escherichia coli and Salmonella enterica in Canadian commercial meat, companion, laboratory, and shelter rabbits (Oryctolagus cuniculus) and its association with routine antimicrobial use in commercial meat rabbits. Prev Vet Med 2017, 147: 53–57. Search in Google Scholar

Martínez J, Hernandis V, Badillo E, Escudero E, Galecio JS, Yuste MT, Marín P: A fast and accurate method for the quantification of doxycycline in goats plasma and milk by HPLC using a fluorescence detector. Acta Vet–Beograd 2024, 74:511–522. Search in Google Scholar

Food and Drug Administration: Bioanalytical Method Validation – Guidance for Industry. 2018 https://www.fda.gov/files/drugs/published/Bioanalytical–Method–Validation–Guidance–for–Industry.pdf Search in Google Scholar

Julious SA, Debarnot CAM: Why are pharmacokinetic data summarized by arithmetic means? J Biopharm Stat 2000, 10: 55–71. Search in Google Scholar

Clark CR: Antimicrobial Drug Use in Sheep and Goats. In Giguére, S., Prescott, J.F., Dowling, P.M. (Ed.), Antimicrobial Therapy in Veterinary Medicine. Hoboken, NJ, USA: John Wiley & Sons, Inc; 2013, 529–539. Search in Google Scholar

Fajt VR: Label and extra label drug use in small ruminants. Vet Clin N Am Food Anim Pract 2001, 17: 403–420. Search in Google Scholar

Jha VK, Jayachandran C, Singh MK, Singh SD: Pharmacokinetic data on doxycycline and its distribution in different biological fluids in female goats. Vet Res Commun 1989, 13: 11–16. Search in Google Scholar

Saivin S, Houin G: Clinical pharmacokinetics of doxycycline and minocycline. Clin Pharmacokinet 1988, 15: 355–366. Search in Google Scholar

Percy DH, Black WD: Pharmacokinetics of tetracycline in the domestic rabbit following intravenous or oral administration. Can J Vet Res 1988, 52: 5–11. Search in Google Scholar

McElroy DE, Ravis WR, Clark CH: Pharmacokinetics of oxytetracycline hydrochloride in rabbits. Am J Vet Res 1987, 48: 1261 – 1263. Search in Google Scholar

Amer AMM, El Badawy SA, Saber MS, Farid OAA, Abd–Elsalam WH, Amer MM: Pharmacokinetics of tetracycline and tetracycline loaded nanoemulsion formula in rabbits. Adv Anim Vet Sci 2020, 8(2): 130–139. Search in Google Scholar

Riond JL, Vaden SL, Riviere JE: Comparative pharmacokinetics of doxycycline in cats and dogs. J Vet Pharmacol Ther 1990, 13: 415–424. Search in Google Scholar

Toutain PL, Bousquet Melou, A: Bioavailability and its assessment. J Vet Pharmacol Ther 2004, 27(6): 455–466. Search in Google Scholar

Baert K, Croubels S, Gasthuys F, De Busser J, De Backer P: Pharmacokinetics and oral bioavailability of a doxycycline formulation (Doxycycline 75%) in nonfasted young pigs. J Vet Pharmacol Ther 2000, 23: 45–48. Search in Google Scholar

Craig WA: Pharmacodynamics of antimicrobials: general concepts and applications. In Nightingale CH, Murakawa T, Ambrose PG (Ed.), Antimicrobial pharmacodynamics in theory and clinical practice (2nd ed). Oxford, England: Marcel Dekker, Inc; 2002, 1–22. Search in Google Scholar

Cunha BA, Domenico P, Cunha CB: Pharmacodynamics of doxycycline. Clin Microbiol Infect 2000, 6(5): 270–273. Search in Google Scholar

Zhang H, Mao C, Li J, Huang Z, Gu X, Shen X, Ding H: Pharmacokinetic/pharmacodynamic integration of doxycycline against Mycoplasma hyopneumoniae in an in vitro model. Front Pharmacol 2019, 10: 1088. Search in Google Scholar

Zhang N, Gu X, Ye X, Wu X, Zhang B, Zhang L, Shen X, Jiang H, Ding H: The PK/PD interactions of doxycycline against Mycoplasma gallisepticum . Front Microbiol 2016, 7: 653–662. Search in Google Scholar

McKellar QA, Sanchez Bruni SF, Jones DG: Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine. J Vet Pharmacol Ther 2004, 27(6): 503–514. Search in Google Scholar

Zhang L, Li Y, Wang Y, Sajid A, Ahmed S, Li X: Integration of pharmacokinetic– pharmacodynamic for dose optimization of doxycycline against Haemophilus parasuis in pigs. J Vet Pharmacol Ther 2018, 41: 706–718. Search in Google Scholar

Toutain PL, Bousquet–Melou A: Free drug fraction vs free drug concentration: A matter of frequent confusion. J Vet Pharmacol Ther 2002, 25(6): 460–463. Search in Google Scholar

Toutain P, Pelligand L, Lees P, Bousquet–Mélou A, Ferran AA, Turnidge JD: The pharmacokinetic/pharmacodynamics paradigm for antimicrobial drugs in veterinary medicine: Recent advances and critical appraisal. J Vet Pharmacol Ther 2021, 44(2): 172–200. Search in Google Scholar

Bryant JE, Brown MP, Gronwall RR, Merritt KA: Study of intragastric administration of doxycycline: pharmacokinetics including body fluid, endometrial and minimum inhibitory concentrations. Equine Vet J 2000, 32(3): 233–238. Search in Google Scholar

Prats C, El Korchi G, Giralt M, Cristòfol C, Peña J, Zorrilla I, Saborit J, Pérez B: PK and PK/PD of doxycycline in drinking water after therapeutic use in pigs. J Vet Pharmacol Therdo 2005, 28: 525–530. Search in Google Scholar

Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Veterinary Medicine