<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite <italic>Babesia canis</italic>. Our hypothesis was that blood redox homeostasis of patients that suffered acute <italic>B. canis</italic> infection might be disturbed even after treatment with imidocarb-dipropionate and successful clinical recovery. Eight owner dogs with acute <italic>B. canis</italic> infection were used for this study. We analyzed the complete blood count, acute phase proteins (ceruloplasmin, haptoglobin, paraoxonase-1) in the serum, antioxidant enzymes (catalase and glutathione peroxidase) in the erythrocytes, and oxidative stress markers (malondialdehyde in erythrocytes and thiol groups in serum) at presentation and 15 days after treatment. Results were evaluated by corresponding statistical tests. At presentation, anemia, low/normal leukocyte count and severe thrombocytopenia occurred together with increased ceruloplasmin, haptoglobin levels within the reference interval, decreased paraoxonase-1 and compromised antioxidant defense in the red blood cells. After treatment and successful clinical recovery, hematological values generally fitted within the reference intervals, acute phase proteins were within the physiological levels in the majority of cases and the activities of the antioxidant enzymes were increased. However, elevated malondialdehyde levels indicated increased oxidative damage of erythrocytes that remained as a deleterious sequel despite a successful clinical recovery of the dogs.</p>
</abstract>

Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was that blood redox homeostasis of patients that suffered acute B. canis infection might be disturbed even after treatment with imidocarb-dipropionate and successful clinical recovery. Eight owner dogs with acute B. canis infection were used for this study. We analyzed the complete blood count, acute phase proteins (ceruloplasmin, haptoglobin, paraoxonase-1) in the serum, antioxidant enzymes (catalase and glutathione peroxidase) in the erythrocytes, and oxidative stress markers (malondialdehyde in erythrocytes and thiol groups in serum) at presentation and 15 days after treatment. Results were evaluated by corresponding statistical tests. At presentation, anemia, low/normal leukocyte count and severe thrombocytopenia occurred together with increased ceruloplasmin, haptoglobin levels within the reference interval, decreased paraoxonase-1 and compromised antioxidant defense in the red blood cells. After treatment and successful clinical recovery, hematological values generally fitted within the reference intervals, acute phase proteins were within the physiological levels in the majority of cases and the activities of the antioxidant enzymes were increased. However, elevated malondialdehyde levels indicated increased oxidative damage of erythrocytes that remained as a deleterious sequel despite a successful clinical recovery of the dogs.

Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute <italic>Babesia canis</italic> Infection in Dogs

Acta Veterinaria

This work is licensed under the Creative Commons Attribution 4.0 International License.

Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute  Infection in Dogs

Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was...

Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs

Published Online: Jul 12, 2021

Page range: 158 - 169

Received: Apr 02, 2021

Accepted: May 24, 2021

DOI: https://doi.org/10.2478/acve-2021-0014

Keywords
acute phase proteins, babesiosis, erythrocytes, inflammation, oxidative stress

© 2021 Kristina Spariosu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs

Published Online: Jul 12, 2021

Page range: 158 - 169

Received: Apr 02, 2021

Accepted: May 24, 2021

DOI: https://doi.org/10.2478/acve-2021-0014

Keywordsacute phase proteins, babesiosis, erythrocytes, inflammation, oxidative stress

© 2021 Kristina Spariosu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
acute phase proteins, babesiosis, erythrocytes, inflammation, oxidative stress