1. bookVolume 70 (2020): Issue 3 (September 2020)
Journal Details
License
Format
Journal
eISSN
1820-7448
First Published
25 Mar 2014
Publication timeframe
4 times per year
Languages
English
access type Open Access

Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

Published Online: 18 Sep 2020
Volume & Issue: Volume 70 (2020) - Issue 3 (September 2020)
Page range: 395 - 400
Received: 05 Oct 2019
Accepted: 18 Feb 2020
Journal Details
License
Format
Journal
eISSN
1820-7448
First Published
25 Mar 2014
Publication timeframe
4 times per year
Languages
English
Abstract

Ganglioneuromatosis is a rare disorder characterized by hyperplasia of intestinal ganglia including myenteric plexus and enteric nerve fibers. This disorder is generally described in children, but sporadic cases have also been described in adults. Most human cases arise in the colon and rectum. The disorder has also been described in dogs, mostly juveniles, but rarely in mature dogs with the oldest dog reported with this change being 9 years old.

We report the first case in an older dog from Croatia. A 13-year old female, mixed-breed dog had a history of diarrhea and weight loss. Ultrasound revealed focally-extensive markedly thickened small intestine. The changed part of the intestine, measuring 7 mm x 20 mm, was removed on laparotomy and delivered for histopathologic examination. Grossly, the intestine showed circumferential expansion of the intestinal wall, which was whitish in color. Microscopic findings included diffuse hyperplasia of the myenteric and submucous plexus. Focally in the affected tissue a subacute ulcer was evident, which was probably not the cause of intestinal signs, as it presented a localized lesion, while ganglioneuromatosis was a diffuse change in the affected tissue.

So far, ganglioneuromatosis was reported in young dogs, rarely in adult dogs. Our report shows that ganglioneuromatosis can also be encountered in older dogs. Although the lesion presents a rare finding, it should be listed as a differential diagnosis in dogs where infectious and neoplastic etiology has been ruled out as cause of diarrhea.

Keywords

1. D’Amore ESG, Manivel JC, Pettinato G, Niehans GG, Snover DC: Intestinal ganglioneuromatosis: mucosal and transmural types. A clinicopathologic and immunohistochemical study of six cases. Hum Pathol 1991, 22:276-286.10.1016/0046-8177(91)90162-ISearch in Google Scholar

2. Higgins RJ, Bollen AW, Dickinson PJ, Sisó-Llonch S: Tumors of the Nervous System. In: Tumors in Domestic Animals, 5th ed. USA: Wiley-Blackwell, 2017, 856-858.Search in Google Scholar

3. Shekitka KM, Sobin LH: Ganglioneuromas of the gastrointestinal tract. Relation to Von Recklinghausen disease and other multiple tumor syndromes. Am J Surg Pathol 1994, 18:250-257.10.1097/00000478-199403000-00004Search in Google Scholar

4. Thway K, Fisher C: Diffuse ganglioneuromatosis in small intestine associated with neurofibromatosis type 1. Ann Pathol 2009, 13:50-54.10.1016/j.anndiagpath.2007.06.001Search in Google Scholar

5. Fairley RA, McEntee F: Colorectal Ganglioneuromatosis in a Young Female Dog (Lhasa Apso). Vet Pathol 1990, 27:206-207.10.1177/030098589002700311Search in Google Scholar

6. Hazell KLA, Reeves MP, Swift IM, Sullivan N: Small intestinal ganglioneuromatosis in a dog. Aust Vet J 2011, 89:15-18.10.1111/j.1751-0813.2010.00663.xSearch in Google Scholar

7. Bemelmans I, Küry S, Albaric O, Hordeaux J, Bertrand L, Nguyen F, Abadie J: Colorectal Hamartomatous Polyposis and Ganglioneuromatosis in a Dog. Vet Pathol 2012, 48(5):1012-1015.10.1177/0300985810384411Search in Google Scholar

8. Paris JK, McCandlish IAP, Schwarz T, Simpson JW, Smith SH: Small Intestinal Ganglioneuromatosis in a Dog. J Comp Path 2013, 148:323-328.10.1016/j.jcpa.2012.07.002Search in Google Scholar

9. Ramírez GA, Altimira J, Vilafranca M: Ganglioneuromatosis of the Gallbladder in a Dog with Cholecystitis and Cholestasis. J Comp Path 2018, 163:29-32.10.1016/j.jcpa.2018.07.002Search in Google Scholar

10. DeSchryver-Kecskemeti K, Clouse RE, Goldstein NM, Gersell D, O’Neal L: Intestinal ganglioneuromatosis. A manifestation of overproduction of nerve growth factor. N Eng J Med 1983, 308:635-639.10.1056/NEJM198303173081106Search in Google Scholar

11. Lee NC, Norton JA: Multiple endocrine neoplasia type 2b: Genetic basis and clinical expression. Surg Oncol 2000, 9:111-118.10.1016/S0960-7404(00)00038-4Search in Google Scholar

12. Qiao S, Iwashita T, Ichihara M, Murakumo Y, Yamaguchi A, Isogai M, Sakata K, Takahashi M: Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis. Clin Neuropathol 2009, 28:105-112.10.5414/NPP28105Search in Google Scholar

13. O’Donnell AM, Puri P: A role for PTEN in paediatric intestinal dysmotility disorders. Pediatr Surg Int 2011,27:491-493.10.1007/s00383-010-2828-621258937Search in Google Scholar

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