<abstract xmlns="http://www.w3.org/1999/xhtml">Peripheral nerve sheath tumors (PNSTs) comprise a heterogeneous group of neoplasms originating from the elements of the nerve sheath. They are divided into two forms: benign and malignant PNST. Both benign and malignant PNSTs are not very common in domestic animals but they are reported in different animal species. Histologically, PNSTs are composed predominantly of spindle cells arranged in bundles, whorls and sheets, with a different number of pleomorphic cells and mitotic figures.The aim of this study was a reclassification of 17 dog tumor samples initially diagnosed with peripheral nerve sheath tumors using histopathological analysis. The main criterion for reclassification was immunohistochemical positivity for various antigens.PNSTs are often histologically very similar to other spindle cell tumors and immunohistochemistry is required for differential diagnosis. PNSTs generally express vimentin, S-100 protein, glial fibrillary acidic protein (GFAP), collagen IV and laminin.Four tumor samples were positive to muscular marker α-SMA and vimentin and negative for S-100 protein and desmin. The spindle cells whirling around some blood vessels were observed in these tumors so they were reclassified as perivascular wall tumors (PWTs). The other 13 tumors were S-100 protein and vimentin positive and α-SMA and desmin negative, thus classified as PNST.The use of the immunohistochemical panel is necessary for distinguishing PNSTs from PWTs in routine diagnostics.</abstract>

Peripheral nerve sheath tumors (PNSTs) comprise a heterogeneous group of neoplasms originating from the elements of the nerve sheath. They are divided into two forms: benign and malignant PNST. Both benign and malignant PNSTs are not very common in domestic animals but they are reported in different animal species. Histologically, PNSTs are composed predominantly of spindle cells arranged in bundles, whorls and sheets, with a different number of pleomorphic cells and mitotic figures.The aim of this study was a reclassification of 17 dog tumor samples initially diagnosed with peripheral nerve sheath tumors using histopathological analysis. The main criterion for reclassification was immunohistochemical positivity for various antigens.PNSTs are often histologically very similar to other spindle cell tumors and immunohistochemistry is required for differential diagnosis. PNSTs generally express vimentin, S-100 protein, glial fibrillary acidic protein (GFAP), collagen IV and laminin.Four tumor samples were positive to muscular marker α-SMA and vimentin and negative for S-100 protein and desmin. The spindle cells whirling around some blood vessels were observed in these tumors so they were reclassified as perivascular wall tumors (PWTs). The other 13 tumors were S-100 protein and vimentin positive and α-SMA and desmin negative, thus classified as PNST.The use of the immunohistochemical panel is necessary for distinguishing PNSTs from PWTs in routine diagnostics.

Immunohistochemical Distinguishing between Canine Peripheral Nerve Sheath Tumors and Perivascular Wall Tumors

Department of Pathology, Faculty of Veterinary Medicine

Scientific Veterinary Institute “Novi Sad”

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Peripheral nerve sheath tumors (PNSTs) comprise a heterogeneous group of neoplasms originating from the elements of the nerve sheath. They are divided into two...

Immunohistochemical Distinguishing between Canine Peripheral Nerve Sheath Tumors and Perivascular Wall Tumors

Published Online: Sep 24, 2019

Page range: 290 - 299

Received: May 13, 2019

Accepted: Jul 27, 2019

DOI: https://doi.org/10.2478/acve-2019-0024

Keywords
canine, immunohistochemistry, peripheral nerve sheath tumors

© 2019 Ivana Vučićević et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Immunohistochemical Distinguishing between Canine Peripheral Nerve Sheath Tumors and Perivascular Wall Tumors

Published Online: Sep 24, 2019

Page range: 290 - 299

Received: May 13, 2019

Accepted: Jul 27, 2019

DOI: https://doi.org/10.2478/acve-2019-0024

Keywordscanine, immunohistochemistry, peripheral nerve sheath tumors

© 2019 Ivana Vučićević et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
canine, immunohistochemistry, peripheral nerve sheath tumors