<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Filamentous fungi are crucial for recycling of organic material in nature. In natural habitats, they cope with many stress factors and therefore their adaptation ability to various conditions is very high. <italic>Trichoderma</italic> sp., fungi used in agriculture as biocontrol agent, are exposed to a variety of toxic molecules including pesticides and fungicides. They have to fight with toxic molecules using stress adaptation mechanisms known as the stress response. Adaptation of fungi to stress, especially to chemical stress, is not well studied in environmental fungal strains. Moreover, the adaptation process presents a risk of resistance mechanism induction to antifungal agents. Such resistant strains could be spread in the environment. This work aims to contribute to the knowledge of the adaptation process spread throughout the fungal kingdom. Transcriptional response of ABC transporters, the main detoxification efflux pumps of subfamily B and G in presence of antifungal agents, is shown. On the other hand, as azoles are the most commonly used antifungal structures in clinical practice and agriculture, changes in important fungal ergosterol biosynthesis genes as a result of their exposure to various azoles structure are highlighted.</p>
</abstract>

Filamentous fungi are crucial for recycling of organic material in nature. In natural habitats, they cope with many stress factors and therefore their adaptation ability to various conditions is very high. Trichoderma sp., fungi used in agriculture as biocontrol agent, are exposed to a variety of toxic molecules including pesticides and fungicides. They have to fight with toxic molecules using stress adaptation mechanisms known as the stress response. Adaptation of fungi to stress, especially to chemical stress, is not well studied in environmental fungal strains. Moreover, the adaptation process presents a risk of resistance mechanism induction to antifungal agents. Such resistant strains could be spread in the environment. This work aims to contribute to the knowledge of the adaptation process spread throughout the fungal kingdom. Transcriptional response of ABC transporters, the main detoxification efflux pumps of subfamily B and G in presence of antifungal agents, is shown. On the other hand, as azoles are the most commonly used antifungal structures in clinical practice and agriculture, changes in important fungal ergosterol biosynthesis genes as a result of their exposure to various azoles structure are highlighted.

Detoxification and adaptation mechanisms of <italic>Trichoderma atroviride</italic> to antifungal agents

Department of Biochemistry and Microbiology, Faculty of Food and Chemical Technology

Slovak University of Technology in Bratislava

Acta Chimica Slovaca

This work is licensed under the Creative Commons Attribution 4.0 International License.

Detoxification and adaptation mechanisms of  to antifungal agents

Filamentous fungi are crucial for recycling of organic material in nature. In natural habitats, they cope with many stress factors and therefore their...

Detoxification and adaptation mechanisms of Trichoderma atroviride to antifungal agents

Published Online: Sep 15, 2022

Page range: 85 - 96

DOI: https://doi.org/10.2478/acs-2022-0010

Keywords
adaptation and tolerance mechanisms of filamentous fungi, detoxification, antifungal agents

© 2022 Zuzana Kubová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Detoxification and adaptation mechanisms of Trichoderma atroviride to antifungal agents

Published Online: Sep 15, 2022

Page range: 85 - 96

DOI: https://doi.org/10.2478/acs-2022-0010

Keywordsadaptation and tolerance mechanisms of filamentous fungi, detoxification, antifungal agents

© 2022 Zuzana Kubová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
adaptation and tolerance mechanisms of filamentous fungi, detoxification, antifungal agents