This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
P. J. Barnes, S. D. Shapiro and R. A. Pauwels, Chronic obstructive pulmonary disease: Molecular and cellular mechanisms, Eur. Respir. J.22 (2003) 672–688; https://doi.org/10.1183/09031936.03.00040703Search in Google Scholar
M. R. Spitz, J. E. Muscat, G. Rennert and K. K. Aben, Risk of lung cancer in family history 48 (2013) 1957–1968; https://doi.org/10.1016/j.ejca.2012.01.038Search in Google Scholar
R. Pauwels, S. Buist, P. Calverley, C. Jenkins and S. Hurd, Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease. NHBLI/WHO global initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary, Rev. Port. Pneumol.7 (2001) 398–400; https://doi.org/10.1016/S0873-2159(15)30846-1Search in Google Scholar
P. J. Barnes, Cellular and molecular mechanisms of chronic obstructive pulmonary disease, Clin. Chest Med.35 (2014) 71–86; https://doi.org/10.1016/j.ccm.2013.10.004Search in Google Scholar
K. M. Beeh, O. Kornmann, R. Buhl, S. V. Culpitt, M. A. Giembycz and P. J. Barnes, Neutrophil chemotactic activity of sputum from patients with COPD, Chest123 (2003) 1240–1247; https://doi.org/10.1378/chest.123.4.1240Search in Google Scholar
Y. Qiu, J. Zhu, V. Bandi, R. L. Atmar, K. Hattotuwa, K. K. Guntupalli and P. K. Jeffery, Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med.168 (2003) 968–975; https://doi.org/10.1164/rccm.200208-794OCSearch in Google Scholar
R. E. K. Russell, A. Thorley, S. V. Culpitt, S. Dodd, L. E. Donnelly, C. Demattos, M. Fitzgerald and P. J. Barnes, Alveolar macrophage-mediated elastolysis: Roles of matrix metalloproteinases, cysteine, and serine proteases, Am. J. Physiol. - Lung Cell. Mol. Physiol.283 (2002) 867–873; https://doi.org/10.1152/ajplung.00020.2002Search in Google Scholar
G. Caramori, M. Romagnoli, P. Casolari, C. Bellettato, G. Casoni, P. Boschetto, K. Fan Chung, P. J. Barnes, I. M. Adcock, A. Ciaccia, L. M. Fabbri and A. Papi, Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations, Thorax58 (2003) 348–351; https://doi.org/10.1136/thorax.58.4.348Search in Google Scholar
J. Wang, R. A. Urbanowicz, P. J. Tighe, I. Todd, J. M. Corne and L. C. Fairclough, Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD), PLoS One8 (2013) 1–9; https://doi.org/10.1371/journal.pone.0058556Search in Google Scholar
K. F. Chung and I. M. Adcock, Multifaceted mechanisms in COPD: Inflammation, immunity, and tissue repair and destruction, Eur. Respir. J.31 (2008) 1334–1356; https://doi.org/10.1183/09031936.00018908Search in Google Scholar
M. Williams, I. Todd and L. C. Fairclough, The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review, Inflamm. Res.70 (2021) 11–18; https://doi.org/10.1007/s00011-020-01408-zSearch in Google Scholar
C. M. Freeman, J. L. Curtis and S. W. Chensue, CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity, Am. J. Pathol.171 (2007) 767–776; https://doi.org/10.2353/ajpath.2007.061177Search in Google Scholar
G. Chrysofakis, N. Tzanakis, D. Kyriakoy, M. Tsoumakidou, I. Tsiligianni, M. Klimathianaki and N. M. Siafakas, Perforin expression and cytotoxic activity of sputum CD8+ lymphocytes in patients with COPD, Chest125 (2004) 71–76; https://doi.org/10.1378/chest.125.1.71Search in Google Scholar
W. C. S. Cho, C. K. Kwan, S. Yau, P. P. F. So, P. C. M. Poon and J. S. K. Au, The role of inflammation in the pathogenesis of lung cancer, Expert Opin. Ther. Targets15 (2011) 1127–1137; https://doi.org/10.1517/14728222.2011.599801Search in Google Scholar
S. Zienolddiny, D. Campa, H. Lind, D. Ryberg, V. Skaug, L. Stangeland, D. H. Phillips, F. Canzian and A. Haugen, Polymorphisms of DNA repair genes and risk of non-small cell lung cancer, Carcinogenesis27 (2006) 560–567; https://doi.org/10.1093/carcin/bgi232Search in Google Scholar
W. Zhou, G. Liu, D. P. Miller, S. W. Thurston, L. L. Xu, J. C. Wain, T. J. Lynch, L. Su and D. C. Chris-tiani, Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk, Cancer Epidemiol. Biomarkers Prev.12 (2003) 359–365.Search in Google Scholar
P. J. Barnes, The cytokine network in chronic obstructive pulmonary disease, Am. J. Respir. Cell Mol. Biol.41 (2009) 631–638; https://doi.org/10.1165/rcmb.2009-0220TRSearch in Google Scholar
B. S. A. Silva, F. S. Lira, D. Ramos, J. S. Uzeloto, F. E. Rossi, A. P. C. F. Freire, R. N. Silva, I. B. Trevisan, L. A. Gobbo and E. M. C. Ramos, Severity of COPD and its relationship with IL-10, Cytokine106 (2018) 95–100; https://doi.org/10.1016/j.cyto.2017.10.018Search in Google Scholar
B. R. Celli, N. Locantore, J. Yates, R. Tal-Singer, B. E. Miller, P. Bakke, P. Calverley, H. Coxson, C. Crim, L. D. Edwards, D. A. Lomas, A. Duvoix, W. MacNee, S. Rennard, E. Silverman, J. Vestbo, E. Wouters and A. Agustí, Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med.185 (2012) 1065–1072; https://doi.org/10.1164/rccm.201110-1792OCSearch in Google Scholar
Y. Wu and B. P. Zhou, TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion, Br. J. Cancer102 (2010) 639–644; https://doi.org/10.1038/sj.bjc.6605530Search in Google Scholar
K. Gong, G. Guo, N. Beckley, Y. Zhang, X. Yang, M. Sharma and A. A. Habib, Tumor necrosis factor in lung cancer: Complex roles in biology and resistance to treatment, Neoplasia23 (2021) 189–196; https://doi.org/10.1016/j.neo.2020.12.006Search in Google Scholar
M. H. Wang, H. J. Cordell and K. Van Steen, Statistical methods for genome-wide association studies, Semin. Cancer Biol.55 (2019) 53–60; https://doi.org/10.1016/j.semcancer.2018.04.008Search in Google Scholar
J. N. Hirschhorn and M. J. Daly, Genome-wide association studies for common diseases and complex traits, Nat. Rev. Genet.6 (2005) 95–108; https://doi.org/10.1038/nrg1521Search in Google Scholar
A. Sud, B. Kinnersley and R. S. Houlston, Genome-wide association studies of cancer: Current insights and future perspectives, Nat. Rev. Cancer17 (2017) 692–704; https://doi.org/10.1038/nrc.2017.82Search in Google Scholar
Y. Bossé and C. I. Amos, A decade of GWAS results in lung cancer, Cancer Epidemiol. Biomarkers Prev.27 (2018) 363–379; https://doi.org/10.1158/1055-9965.EPI-16-0794Search in Google Scholar
M. S. Shiels, E. A. Engels, J. Shi, M. T. Landi, D. Albanes, N. Chatterjee, S. J. Chanock, N. E. Caporaso and A. K. Chaturvedi, Genetic variation in innate immunity and inflammation pathways associated with lung cancer risk, Cancer118 (2012) 5630–5636; https://doi.org/10.1002/cncr.27605Search in Google Scholar
Q. Wang, J. Gu, L. Wang, D. W. Chang, Y. Ye, M. Huang, J. A. Roth and X. Wu, Genetic associations of T cell cancer immune response-related genes with T cell phenotypes and clinical outcomes of early-stage lung cancer, J. Immunother. Cancer8 (2020) Article ID e000336; (13 pages); https://doi.org/10.1136/jitc-2019-000336Search in Google Scholar
D. Watza, C. M. Lusk, G. Dyson, K. S. Purrington, A. S. Wenzlaff, C. Neslund-Dudas, A. O. Soubani, S. M. Gadgeel and A. G. Schwartz, COPD-dependent effects of genetic variation in key inflammation pathway genes on lung cancer risk, Int. J. Cancer147 (2020) 747–756; https://doi.org/10.1002/ijc.32780Search in Google Scholar
J. Chen, R. Y. Liu, L. Yang, J. Zhao, X. Zhao, D. Lu, N. Yi, B. Han, X. F. Chen, K. Zhang, J. He, Z. Lei, Y. Zhou, B. Pasche, X. Li and H. T. Zhang, A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk, J. Cancer Res. Clin. Oncol.139 (2013) 231–242; https://doi.org/10.1007/s00432-012-1314-zSearch in Google Scholar
I. A. Yang, J. W. Holloway and K. M. Fong, Genetic susceptibility to lung cancer and co-morbidities, J. Thorac. Dis.5(Supl. 5) (2013) S454–S462; https://doi.org/10.3978/j.issn.2072-1439.2013.08.06Search in Google Scholar
C. Sudlow, J. Gallacher, N. Allen, V. Beral, P. Burton, J. Danesh, P. Downey, P. Elliott, J. Green, M. Landray, B. Liu, P. Matthews, G. Ong, J. Pell, A. Silman, A. Young, T. Sprosen, T. Peakman and R. Collins, UK biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age, PLoS Med.12 (2015) 1–10; https://doi.org/10.1371/journal.pmed.1001779Search in Google Scholar
S. A. Miller, D. D. Dykes and H. F. Polesky, A simple salting out procedure for extracting DNA from human nucleated cells, Nucleic Acids Res.16(3) (1988) Article ID 1215 (1 page); https://doi.org/10.1093/nar/16.3.1215Search in Google Scholar
D. C. Rio, M. Ares, G. J. Hannon and T. W. Nilsen, Purification of RNA using TRIzol (TRI Reagent), Cold Spring Harb. Protoc.5 (2010) 1–4; https://doi.org/10.1101/pdb.prot5439Search in Google Scholar
K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method, Methods25 (2001) 402–408; https://doi.org/10.1006/meth.2001.1262Search in Google Scholar
H. Arora, S. M. Wilcox, L. A. Johnson, L. Munro, B. A. Eyford, C. G. Pfeifer, I. Welch and W. A. Jefferies, The ATP-binding cassette gene ABCF1 functions as an E2 ubiquitin-conjugating enzyme controlling macrophage polarization to dampen lethal septic shock, Immunity50(2) (2019) Article ID e6, 418–431; https://doi.org/10.1016/j.immuni.2019.01.014Search in Google Scholar
Q. T. Cao, J. A. Aguiar, B. J. M. Tremblay, N. Abbas, N. Tiessen, S. Revill, N. Makhdami, A. Ayoub, G. Cox, K. Ask, A. C. Doxey and J. A. Hirota, ABCF1 regulates dsDNA-induced immune responses in human airway epithelial cells, Front. Cell. Infect. Microbiol.10 (2020) 1–17; https://doi.org/10.3389/fcimb.2020.00487Search in Google Scholar
V. Zachariou, R. S. Duman and E. J. Nestler, G proteins, Basic Neurochem. (2012) 411–422; https://doi.org/10.1016/B978-0-12-374947-5.00021-3Search in Google Scholar
C. C. Fraser, G protein-coupled receptor connectivity to NF-κB in inflammation and cancer, Int. Rev. Immunol.27 (2008) 320–350; https://doi.org/10.1080/08830180802262765Search in Google Scholar
F. Bazzoni and B. Beutler, The tumor necrosis factor ligand and receptor families, N. Engl. J. Med.334 (1996) 1717–1725.Search in Google Scholar
M. M. Stankovic, A. R. Nestrovic, A. M. Tomovic, N. D. Petrovic-Stanojevic, M. S. Andjelic-Jelic, V. B. Dopudja-Pantic, L. M. Nagorni-Obradovic, M. M. Mitic-Milikic and D. P. Radojkovic, TNF-α-308 promotor polymorphism in patients with chronic obstructive pulmonary disease and lung cancer, Neoplasma56 (2009) 348–352; https://doi.org/10.4149/neo_2009_04_348Search in Google Scholar
C. M. Shih, Y. L. Lee, H. L. Chiou, W. Chen, G. C. Chang, M. C. Chou and L. Y. Lin, Association of TNF-α polymorphism with susceptibility to and severity of non-small cell lung cancer, Lung Cancer52 (2006) 15–20; https://doi.org/10.1016/j.lungcan.2005.11.011Search in Google Scholar
C. A. van der Weyden, S. A. Pileri, A. L. Feldman, J. Whisstock and H. M. Prince, Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight into future directions, Blood Cancer J.7 (2017) Article ID e603 (10 pages); https://doi.org/10.1038/bcj.2017.85Search in Google Scholar
J. S. Brody and A. Spira, Chronic obstructive pulmonary disease, inflammation, and lung cancer, Proc. Am. Thorac. Soc.3 (2006) 535–537; https://doi.org/10.1513/pats.200603-089MSSearch in Google Scholar
T. Liu, L. Zhang, D. Joo and S. C. Sun, NF-κB signaling in inflammation, Signal Transduct. Target. Ther.2 (2017) Article ID 17023 (9 pages); https://doi.org/10.1038/sigtrans.2017.23Search in Google Scholar
J. Wang, R. Ferreira, W. Lu, S. Farrow, K. Downes, L. Jermutus, R. Minter, R. S. Al-Lamki, J. S. Pober and J. R. Bradley, TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway, Sci. Rep.8 (2018) 1–11; https://doi.org/10.1038/s41598-018-30621-4Search in Google Scholar
T. C. Cheung, M. W. Steinberg, L. M. Oborne, M. G. Macauley, S. Fukuyama, H. Sanjo, C. D’Souza, P. S. Norris, K. Pfeffer, K. M. Murphy, M. Kronenberg, P. G. Spear and C. F. Ware, Unconventional ligand activation of herpesvirus entry mediator signals cell survival, Proc. Natl. Acad. Sci. U. S. A.106 (2009) 6244–6249; https://doi.org/10.1073/pnas.0902115106Search in Google Scholar
D. S. Vinay and B. S. Kwon, 4-1BB signaling beyond T cells, Cell. Mol. Immunol.8 (2011) 281–284; https://doi.org/10.1038/cmi.2010.82Search in Google Scholar
C. Z. Ni, K. Welsh, E. Leo, C. K. Chiou, H. Wu, J. C. Reed and K. R. Ely, Molecular basis for CD40 signaling mediated by TRAF3, Proc. Natl. Acad. Sci. U. S. A.97 (2000) 10395–10399; https://doi.org/10.1073/pnas.97.19.10395Search in Google Scholar
P. Bista, W. Zeng, S. Ryan, V. Bailly, J. L. Browning and M. E. Lukashev, TRAF3 controls activation of the canonical and alternative NFκB by the lymphotoxin beta receptor, J. Biol. Chem.285 (2010) 12971–12978; https://doi.org/10.1074/jbc.M109.076091Search in Google Scholar
A. Oeckinghaus and S. Ghosh, The NF-kappaB family of transcription factors and its regulation., Cold Spring Harb. Perspect. Biol.1 (2009) 1–14; https://doi.org/10.1101/cshperspect.a000034Search in Google Scholar
R. Zaynagetdinov, T. P. Sherrill, L. A. Gleaves, P. Hunt, W. Han, A. G. McLoed, J. A. Saxon, H. Tanjore, P. M. Gulleman, L. R. Young and T. S. Blackwell, Chronic NF-κB activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs, Onco-target7 (2016) 5470–5482; https://doi.org/10.18632/oncotarget.6562Search in Google Scholar
T. R. Malek and I. Castro, Interleukin-2 receptor signaling: At the interface between tolerance and immunity, Immunity33 (2010) 153–165; https://doi.org/10.1016/j.immuni.2010.08.004Search in Google Scholar
M. Permanyer, B. Bošnjak, S. Glage, M. Friedrichsen, S. Floess, J. Huehn, G. E. Patzer, I. Odak, N. Eckert, R. Zargari, L. Ospina-Quintero, H. Georgiev and R. Förster, Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool, Cell. Mol. Immunol.18 (2021) 398–414; https://doi.org/10.1038/s41423-020-00599-zSearch in Google Scholar
F. Herr, R. Lemoine, F. Gouilleux, D. Meley, I. Kazma, A. Heraud, F. Velge-Roussel, C. Baron and Y. Lebranchu, IL-2 phosphorylates STAT5 to drive IFN-γ production and activation of human dendritic cells, J. Immunol.192 (2014) 5660–5670; https://doi.org/10.4049/jimmunol.1300422Search in Google Scholar
A. L. McDoniels-Silvers, G. D. Stoner, R. A. Lubet and M. You, Differential expression of critical cellular genes in human lung adenocarcinomas and squamous cell carcinomas in comparison to normal lung tissues, Neoplasia4 (2002) 141–150; https://doi.org/10.1038/sj/neo/7900217Search in Google Scholar
Z. Jia, Z. Zhang, Q. Yang, C. Deng, D. Li and L. Ren, Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk, Int. Immunopharmacol.74 (2019) Article ID 105716; https://doi.org/10.1016/j.intimp.2019.105716Search in Google Scholar
Q. Guan, Y. Tian, Z. Zhang, L. Zhang, P. Zhao and J. Li, Identification of potential key genes in the pathogenesis of chronic obstructive pulmonary disease through bioinformatics analysis, Front. Genet.12 (2021) Article ID 754569 (11 pages); https://doi.org/10.3389/fgene.2021.754569Search in Google Scholar
H. Kato and A. Perl, Double-edged sword: Interleukin-2 promotes T regulatory cell differentiation but also expands interleukin-13- and interferon-γ-producing CD8+ T cells via STAT6-GATA-3 axis in systemic lupus erythematosus, Front. Immunol.12 (2021) Article ID 635531 (9 pages); https://doi.org/10.3389/fimmu.2021.635531Search in Google Scholar
Y. Zhang, L. Ren, J. Sun, F. Han and X. Guo, Increased serum soluble interleukin-2 receptor associated with severity of acute exacerbation of chronic obstructive pulmonary disease, Int. J. Chron. Obstruct. Pulmon. Dis.16 (2021) 2561–2573; https://doi.org/10.2147/COPD.S321904Search in Google Scholar