Adverse drug reactions in the ambulatory internal patients at the emergency department: Focus on causality assessment and drug-drug interactions

1 S. Sundaran, A. Udayan, K. Hareendranath, B. Eliyas, B. Ganesan, A. Hassan, R. Subash, V. Palakkal and M. S. Salahudeen, Study on the classification, causality, preventability and severity of adverse drug reaction using spontaneous reporting system in hospitalized patients, Pharmacy 6(4) (2018) Article ID 108 (9 pages); https://doi.org/10.3390/pharmacy6040108 Search in Google Scholar

2 O. Laatikainen, S. Sneck and M. Turpeinen, Medication-related adverse events in health care—what have we learned? A narrative overview of the current knowledge, Eur. J. Clin. Pharmacol.78 (2022) 159–170; https://doi.org/10.1007/s00228-021-03213-x Search in Google Scholar

3 J. J. Coleman and S. K. Pontefract, Adverse drug reactions, Clin. Med. 16(5) (2016) 481–485; https://doi.org/10.7861/clinmedicine.16-5-481 Search in Google Scholar

4 A. M. Schurig, M. Böhme, K. S. Just, C. Scholl, H. Dormann, B. Plank-Kiegele, T. Seufferlein, I. Gräff, M. Schwab and J. C. Stingl, Adverse drug reactions (ADR) and emergencies-the prevalence of suspected ADR in four emergency departments in Germany, Dtsch. Arztebl. Int. 115 (2018) 251–258; https://doi.org/10.3238/arztebl.2018.0251 Search in Google Scholar

5 T. M. Yadesa, F. E. Kitutu, S. Deyno, P. E. Ogwang, R. Tamukong and P. E. Alele, Prevalence, characteristics and predicting risk factors of adverse drug reactions among hospitalized older adults: A systematic review and meta-analysis, SAGE Open Med. 9 (2021) 1–14; https://doi.org/10.1177/20503121211039099 Search in Google Scholar

6 T. M. Alhawassi, I. Krass, B. Bajorek and L. G. Pont, A systematic review of the prevalence and risk factors for adverse drug reactions in the elderly in the acute care setting, Clin. Interv. Aging 9 (2014) 2079–2086; https://doi.org/10.2147/CIA.S71178 Search in Google Scholar

7 M. Kauppila, J. T. Backman, M. Niemi and O. Lapatto-Reiniluoto, Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department, Eur. J. Clin. Pharmacol. 77 (2021) 643–650; https://doi.org/10.1007/s00228-020-03043-3 Search in Google Scholar

8 C. Pedrós, F. Formiga, X. Corbella and J. M. Arnau, Adverse drug reactions leading to urgent hospital admission in an elderly population: Prevalence and main features, Eur. J. Clin. Pharmacol. 72 (2016) 219–226.; https://doi.org/10.1007/s00228-015-1974-0 Search in Google Scholar

9 J. Ma, Y. Wang, M. Gao, Q. Meng and J. Liu, Adverse drug reactions as the cause of emergency department admission of patients aged 80 years and older, Eur. J. Intern. Med. 23(6) (2012) e162-e163; https://doi.org/10.1016/j.ejim.2012.05.004 Search in Google Scholar

10 N. Fokter, M. Možina and M. Brvar, Potential drug-drug interactions and admissions due to drug-drug interactions in patients treated in medical departments, Wiener Klin. Wochenschr. 122 (2010) 81–88; https://doi.org/10.1007/s00508-009-1251-2 Search in Google Scholar

11 S. K. Behera, S. Das, A. S. Xavier, S. Velupula and S. Sandhiya, Comparison of different methods for causality assessment of adverse drug reactions, Int. J. Clin. Pharm. 40 (2018) 903–910; https://doi.org/10.1007/s11096-018-0694-9 Search in Google Scholar

12 S. Pande, Causality or relatedness assessment in adverse drug reaction and its relevance in dermatology, Indian J. Dermatol. 63(1) (2018) 18–21; https://doi.org/10.4103/IJD.IJD_579_17 Search in Google Scholar

13 The Uppsala Monitoring Centre. The Use of the WHO-UMC System for Standardised Case Causality Assessment, June 2013; https://www.who.int/publications/m/item/WHO-causality-assessment; last access date November 10, 2022. Search in Google Scholar

14 C. A. Naranjo, U. Busto, E. M. Sellers, P. Sandor, I. Ruiz, E. A. Roberts, E. Janacek, C. Domecq and D. J. Greenblatt, A method for estimating the probability of adverse drug reactions, Clin. Pharmacol. Ther. 30 (1981) 239–245; https://doi.org/10.1038/CLPT.1981.154 Search in Google Scholar

15 T. J. Oscanoa, F. Lizaraso and A. Carvajal, Hospital admissions due to adverse drug reactions in the elderly. A meta-analysis, Eur. J. Clin. Pharmacol. 73 (2017) 759–770; https://doi.org/10.1007/s00228-017-2225-3 Search in Google Scholar

16 K. S. Just, H. Dormann, M. Schurig, M. Böhme, M. Steffens, B. Plank-Kiegele, K. Ettrich, T. Seufferlein, I. Gräff, S. Igel, S. Schricker, S. U. Jaeger, M. Schwab and J. C. Stingl, The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study, Br. J. Clin. Pharmacol. 86 (2020) 2144–2154; https://doi.org/10.1111/bcp.14304 Search in Google Scholar

17 M. Kyonen, I. Folatre, X. Lagos and S. Vargas, Comparison of two methods to assess causality of adverse drug reactions, Rev. Med. Chile 143(7) (2015) 880–886; https://doi.org/10.4067/s0034-98872015000700009 Search in Google Scholar

18 L. Magro, E. Arzenton, R. Leone, M. G. Stano, M. Vezzaro, A. Rudolph, I. Castagna and U. Moretti, Identifying and characterizing serious adverse drug reactions associated with drug-drug interactions in a spontaneous reporting database, Front. Pharmacol. 11 (2021) Article ID 622862 (9 pages); https://doi.org/10.3389/fphar.2020.622862 Search in Google Scholar

19 T. N. G. de Andrade Santos, G. M. da Cruz Macieira, B. M. C. Sodré Alves, T. Onozato, G. C. Cardoso, M. T. F. Nascimento, P. R. S. Martins-Filho, D. P. de Lyra, Jr. and A. D. de Oliveira Filho, Prevalence of clinically manifested drug interactions in hospitalized patients: A systematic review and meta-analysis, PLoS ONE 15(7) (2020) e0235353 (14 pages); https://doi.org/10.1371/journal.pone.0235353 Search in Google Scholar

20 P. Olivier, L. Bertrand, M. Tubery, D. Lauque, J. L. Montastruc and M. Lapeyre-Mestre, Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department: A prospective survey, Drugs Aging 26 (2009) 475–482; https://doi.org/10.2165/00002512-200926060-00004 Search in Google Scholar

21 C. Bucşa, A. Farcaş, I. Cazacu, D. Leucuta, A. Achimas-Cadariu, C. Mogosan and M. Bojita, How many potential drug-drug interactions cause adverse drug reactions in hospitalized patients?, Eur. J. Intern. Med. 24 (2013) 27–33; https://doi.org/10.1016/j.ejim.2012.09.011 Search in Google Scholar

22 L. M. De Oliveira, J. D. A. C. Diel, A. Nunes and T. Da Silva Dal Pizzol, Prevalence of drug interactions in hospitalised elderly patients: A systematic review, Eur. J. Hosp. Pharm. 28 (2021) 4–9; https://doi.org/10.1136/ejhpharm-2019-002111 Search in Google Scholar

23 Official Gazette of the Republic of Slovenia, No. 17/14 and 66/19, Medicinal Products Act, http://www.pisrs.si/Pis.web/pregledPredpisa?id=ZAKO6295; last access date November 9, 2022. Search in Google Scholar

24 Official Gazette of the Republic of Slovenia, No. 57/14 and 27/17, Rules on Pharmacovigilance of Medicinal Products for Human Use; http://www.pisrs.si/Pis.web/pregledPredpisa?id=PRAV12129; last access date November 9, 2022. Search in Google Scholar

25 U. S. Department of Health and Human Services, Common Terminology Criteria for Adverse Events (CTCAE) – Version 5.0, Nov 27, 2017; https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcae_v5_quick_reference_5x7.pdf; last visit November 9, 2022 Search in Google Scholar

26 S. Gautron, J. Wentzell, S. Kanji, T. Nguyen, D. M. Kobewka and E. MacDonald, Characterization of serious adverse drug reactions in hospital to determine potential implications of mandatory reporting, Can. J. Hosp. Pharm. 71 (2018) 316–323. Search in Google Scholar

27 S. L. Chan, X. Ang, L. L. Sani, H. Y. Ng, M. D. Winther, J. J. Liu, L. R. Brunham and A. Chan, Prevalence and characteristics of adverse drug reactions at admission to hospital: a prospective observational study, Br. J. Clin. Pharmacol. 82 (2016) 1636–1646; https://doi.org/10.1111/bcp.13081 Search in Google Scholar

28 S. Dechanont, S. Maphanta, B. Butthum and C. Kongkaew, Hospital admissions/visits associated with drug-drug interactions: a systematic review and meta-analysis, Pharmacoepidemiol. Drug Saf. 23 (2014) 489–497; https://doi.org/10.1002/pds Search in Google Scholar

29 H. Murayama, M. Sakuma, Y. Takahashi and T. Morimoto, Improving the assessment of adverse drug reactions using the Naranjo algorithm in daily practice: The Japan adverse drug events study, Pharmacol. Res. Perspect. 6(1) (2018) e00373 (7 pages); https://doi.org/10.1002/prp2.373 Search in Google Scholar

30 A. Ghosh, A. Hegde, S. Grover, Mirtazapine-associated hyponatremia presenting as delirium, Indian J. Pharmacol. 46(4) (2014) 448–449; https://doi.org/10.4103/0253-7613.135964 Search in Google Scholar

31 E. Tantisattamo, A. Chokechanachaisakul, S. Pitukweerakul, P. Ratanasrimetha, P. Shrivastava and D. Samarapungavan, Calcineurin inhibitor-induced hyperkalemia and salt-sensitive hypertension in early post-kidney transplant period, FASEB J. 30(S1) (2016) 916.19-916.19; https://doi.org/10.1096/fasebj.30.1_supplement.916.19 Search in Google Scholar

32 M. A. Raebel, Hyperkalemia associated with use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, Cardiovasc. Ther. 30(3) (2012) e156–e166; https://doi.org/10.1111/j.1755-5922.2010.00258.x Search in Google Scholar

33 M. Becker, M. Kallewaard, P. W. J. Caspers, L. E. Visser, H. G. M. Leufkens and B. H. Ch. Stricker, Hospitalisations and emergency department visits due to drug-drug interactions: a literature review, Pharmacoepidemiol. Drug Saf. 16(6) (2007) 641–651; https://doi.org/10.1002/pds.1351 Search in Google Scholar

34 W. Y. Zheng, L. C. Richardson, L. Li, R. O. Day, J. I. Westbrook and M. T. Baysari, Drug-drug interactions and their harmful effects in hospitalised patients: a systematic review and meta-analysis, Eur. J. Clin. Pharmacol. 74 (2018) 15–27; https://doi.org/10.1007/S00228-017-2357-5 Search in Google Scholar

35 N. Muhič, A. Mrhar and M. Brvar, Comparative analysis of three drug-drug interaction screening systems against probable clinically relevant drug-drug interactions: a prospective cohort study, Eur. J. Clin. Pharmacol. 73 (2017) 875–882; https://doi.org/10.1007/s00228-017-2232-4 Search in Google Scholar

36 A. J. Karter, Role of self-monitoring of blood glucose in glycemic control, Endocr. Pract. 12(Suppl. 1) (2006) 110–117; https://doi.org/10.4158/EP.12.S1.110 Search in Google Scholar

37 E. Espinel, J. Joven, I. Gil, P. Suñé, B. Renedo, J. Fort and D. Serón, Risk of hyperkalemia in patients with moderate chronic kidney disease initiating angiotensin converting enzyme inhibitors or angiotensin receptor blockers: a randomized study, BMC Res. Notes 6 (2013) Article ID 306 (9 pages); https://doi.org/10.1186/1756-0500-6-306 Search in Google Scholar

38 C. Bhanu, D. Nimmons, I. Petersen, M. Orlu, D. Davis, H. Hussain, S. Magammanage and K. Walters, Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled trials, PLoS Med. 18(11) (2021) e1003821 (14 pages); https://doi.org/10.1371/journal.pmed.1003821 Search in Google Scholar

39 A.S. Abuzour, G. Hoad-Reddick, M. Shahid, D. T. Steinke, M. P. Tully, S. D. Williams and P. J. Lewis, Patient prioritisation for hospital pharmacy services: current approaches in the UK, Eur. J. Hosp. Pharm. 28(Suppl. 2) (2021) e102–e108; https://doi.org/10.1136/ejhpharm-2020-002365 Search in Google Scholar

40 L. Létinier, A. Ferreira, A. Marceron, M. Babin, J. Micallef, G. Miremont-Salamé and A. Pariente, Spontaneous reports of serious adverse drug reactions resulting from drug–drug interactions: An analysis from the French pharmacovigilance database, Front. Pharmacol. 11 (2021) Article ID 624562 (8 pages); https://doi.org/10.3389/fphar.2020.624562 Search in Google Scholar

41 M. Lucic, P. Milosević, B. N. Martić, M. M. Paut-Kusturica, M. Jovančević, B. M. Ubavić, B. Todorovic, J. D. Krajačić and L. A. Rašković, The role of a pharmacist in pharmacovigilance system, J. Hosp. Pharmacol. 5(3) (2018) 715–727; https://doi.org/10.5937/HPIMJ1803715L Search in Google Scholar

42 S. L. Gray, L. A. Hart, S. Perera, T. P. Semla, K. E. Schmader and J. T. Hanlon, Meta-analysis of interventions to reduce adverse drug reactions in older adults, J. Am. Geriatr. Soc. 66(2) (2018) 282–288; https://doi.org/10.1111/jgs.15195 Search in Google Scholar