<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>This study evaluated the anti-inflammation effect of the three main short-chain fatty acids (SCFAs) on <italic>Acinetobacter baumannii</italic>-induced THP-1 cells. The three main SCFAs could inhibit <italic>A. baumannii</italic>-stimulated THP-1 cell NF-κB pathway activity and the expressions of NLRP3 inflamma-some and GSDMD, and increase autophagy. The three main SCFAs, especially the sodium butyrate (NaB), had the effect of down-regulation of ROS and <italic>TLR-2</italic> expression in THP-1 cells. NaB and sodium propionate (NaPc), but not sodium acetate (NaAc), dramatically suppressed <italic>IL-1β</italic> and <italic>IFN-γ</italic> expression. The results indicated that NaB and NaPc could significantly inhibit the inflammation of THP-1 cells induced by <italic>A. baumannii</italic>, and the inhibitory effect was in the order of NaB > NaPc > NaAC. NaB and NaPc may inhibit inflammation through TLR-2/NF-κB/ROS/NLRP3 signaling pathway.</p>
</abstract>

This study evaluated the anti-inflammation effect of the three main short-chain fatty acids (SCFAs) on Acinetobacter baumannii-induced THP-1 cells. The three main SCFAs could inhibit A. baumannii-stimulated THP-1 cell NF-κB pathway activity and the expressions of NLRP3 inflamma-some and GSDMD, and increase autophagy. The three main SCFAs, especially the sodium butyrate (NaB), had the effect of down-regulation of ROS and TLR-2 expression in THP-1 cells. NaB and sodium propionate (NaPc), but not sodium acetate (NaAc), dramatically suppressed IL-1β and IFN-γ expression. The results indicated that NaB and NaPc could significantly inhibit the inflammation of THP-1 cells induced by A. baumannii, and the inhibitory effect was in the order of NaB > NaPc > NaAC. NaB and NaPc may inhibit inflammation through TLR-2/NF-κB/ROS/NLRP3 signaling pathway.

Anti-inflammatory effects of NaB and NaPc in <italic>Acinetobacter baumannii</italic>-stimulated THP-1 cells <italic>via</italic> TLR-2/NF-κB/ROS/NLRP3 pathway

The First Affiliated Hospital of Soochow University Suzhou

Affiliated Hospital of Jiangsu University

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Anti-inflammatory effects of NaB and NaPc in -stimulated THP-1 cells  TLR-2/NF-κB/ROS/NLRP3 pathway

This study evaluated the anti-inflammation effect of the three main short-chain fatty acids (SCFAs) on Acinetobacter baumannii-induced THP-1 cells. The three...

Anti-inflammatory effects of NaB and NaPc in Acinetobacter baumannii-stimulated THP-1 cells via TLR-2/NF-κB/ROS/NLRP3 pathway

Published Online: Oct 18, 2022

Page range: 615 - 628

Accepted: Apr 11, 2022

DOI: https://doi.org/10.2478/acph-2022-0036

Keywords
short-chain fatty acids (SCFAs), autophagy, NLRP3, nuclear factor-κB (NF-κB), inflammation

© 2022 Chen Shu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Anti-inflammatory effects of NaB and NaPc in Acinetobacter baumannii-stimulated THP-1 cells via TLR-2/NF-κB/ROS/NLRP3 pathway

Published Online: Oct 18, 2022

Page range: 615 - 628

Accepted: Apr 11, 2022

DOI: https://doi.org/10.2478/acph-2022-0036

Keywordsshort-chain fatty acids (SCFAs), autophagy, NLRP3, nuclear factor-κB (NF-κB), inflammation

© 2022 Chen Shu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
short-chain fatty acids (SCFAs), autophagy, NLRP3, nuclear factor-κB (NF-κB), inflammation