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Acta Pharmaceutica
Volume 69 (2019): Issue 3 (September 2019)
Open Access
Metabolic stability and its role in the discovery of new chemical entities
Karolina Słoczyńska
Karolina Słoczyńska
Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College
Krakow, Poland
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Słoczyńska, Karolina
,
Agnieszka Gunia-Krzyżak
Agnieszka Gunia-Krzyżak
Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College
Krakow, Poland
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Gunia-Krzyżak, Agnieszka
,
Paulina Koczurkiewicz
Paulina Koczurkiewicz
Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College
Krakow, Poland
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Koczurkiewicz, Paulina
,
Katarzyna Wójcik-Pszczoła
Katarzyna Wójcik-Pszczoła
Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College
Krakow, Poland
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Wójcik-Pszczoła, Katarzyna
,
Dorota Żelaszczyk
Dorota Żelaszczyk
Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College
Krakow, Poland
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Żelaszczyk, Dorota
,
Justyna Popiół
Justyna Popiół
Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College
Krakow, Poland
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Popiół, Justyna
and
Elżbieta Pękala
Elżbieta Pękala
Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College
Krakow, Poland
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Pękala, Elżbieta
Jun 26, 2019
Acta Pharmaceutica
Volume 69 (2019): Issue 3 (September 2019)
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Published Online:
Jun 26, 2019
Page range:
345 - 361
Accepted:
Dec 29, 2018
DOI:
https://doi.org/10.2478/acph-2019-0024
Keywords
metabolic stability
,
biotransformation
,
intrinsic clearance
,
half-life
,
metabolites
,
new chemical entity
© 2019 Karolina Słoczyńska et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
