Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents

1. N. C. Desai, H. Somani, A. Trivedi, K. Bhatt, L. Nawale, V. M. Khedkar, P. C. Jha and D. Sarkar, Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents, Bioorg. Med. Chem. Lett. 26 (2016) 1776–1783; https://doi.org/10.1016/j.bmcl.2016.02.04310.1016/j.bmcl.2016.02.043Search in Google Scholar

2. A. G. Banerjee, N. Das, S. A. Shengule, R. S. Srivastava and S. K. Shrivastava, Synthesis, characterization, evaluation and molecular dynamics studies of 5,6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti–inflammatory and analgesic agents, Eur. J. Med. Chem. 101 (2015) 81–95; https://doi.org/10.1016/j.ejmech.2015.06.02010.1016/j.ejmech.2015.06.020Search in Google Scholar

3. W. Wu, Q. Chen, A. Tai, G. Jiang and G. Ouyang, Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives, Bioorg. Med. Chem. Lett. 25 (2015) 2243–2246; https://doi.org/10.1016/j.bmcl.2015.02.06910.1016/j.bmcl.2015.02.069Search in Google Scholar

4. S. Zhang, Y. Luo, L. Q. He, Z. J. Liu, A. Q. Jiang, Y. H. Yang and H. L. Zhu, Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity, Bioorg. Med. Chem. 21 (2013) 3723–3729; https://doi.org/10.1016/j.bmc.2013.04.04310.1016/j.bmc.2013.04.043Search in Google Scholar

5. R. A. Rane, S. D. Gutte and N. U. Sahu, Synthesis and evaluation of novel 1,3,4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent, Bioorg. Med. Chem. Lett. 22 (2012) 6429–6432; https://doi.org/10.1016/j.bmcl.2012.08.06110.1016/j.bmcl.2012.08.061Search in Google Scholar

6. Y. Kotaiah, N. Harikrishna, K. Nagaraju and C. V. Rao, Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives, Eur. J. Med. Chem. 58 (2012) 340–345; https://doi.org/10.1016/j.ejmech.2012.10.00710.1016/j.ejmech.2012.10.007Search in Google Scholar

7. N. C. Desai, N. Bhatt, H. Somani and A. Trivedi, Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles, Eur. J. Med. Chem. 67 (2013) 54–59; https://doi.org/10.1016/j.ejmech.2013.06.02910.1016/j.ejmech.2013.06.029Search in Google Scholar

8. M. Mahesh, G. Bheemaraju, G. Manjunath and P. V. Ramana, Synthesis of new oxadiazole, pyrazole and pyrazolin-5-one bearing 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy) acetohydrazide analogs as potential antibacterial and antifungal agents, Ann. Pharm. Fran. 74 (2016) 34–44; https://doi.org/10.1016/j.pharma.2015.07.00210.1016/j.pharma.2015.07.002Search in Google Scholar

9. J. Wu, B. Song, H. Chen, P. Bhadury and D. Hu, Synthesis and antifungal activity of 5-chloro-6-phenylpyridazin-3(2H)-one derivatives, Molecules14 (2009) 3676–3687; https://doi.org/10.3390/molecules1409367610.3390/molecules14093676Search in Google Scholar

10. J. D. S. Chaves, L. G. Tunes, C. H. de J. Franco, T. M. Francisco, C. C. Corrêa, S. M. F. Murta, R. L. Monte-Neto, H. Silva, A. P. S. Fontes and M. V. de Almeida, Novel gold(I) complexes with 5-phenyl-1,3,4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents, Eur. J. Med. Chem. 127 (2017) 727–739; https://doi.org/10.1016/j.ejmech.2016.10.05210.1016/j.ejmech.2016.10.052Search in Google Scholar

11. P. Puthiyapurayil, B. Poojary, C. Chikkanna and S. K. Buridipad, Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents, Eur. J. Med. Chem. 53 (2012) 203–210; https://doi.org/10.1016/j.ejmech.2012.03.05610.1016/j.ejmech.2012.03.056Search in Google Scholar

12. S. Bansal, M. Bala, S. K. Suthar, S. Choudhary, S. Bhattacharya, V. Bhardwaj, S. Singla and A. Joseph, Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity, Eur. J. Med. Chem. 80 (2014) 167–174; https://doi.org/10.1016/j.ejmech.2014.04.04510.1016/j.ejmech.2014.04.045Search in Google Scholar

13. S. R. Desai, U. Laddi, R. S. Bennur, P. A. Patil and S. Bennur, Synthesis and pharmacological activities of some new 5-substituted-2-mercapto-1,3,4-oxadiazoles, Indian J. Pharm. Sci. 73 (2011) 593–596; https://doi.org/10.4103/0250-474X.9902510.4103/0250-474X.99025Search in Google Scholar

14. E. De Clercq, T. Sakuma, M. Baba, R. Pauwels, J. Balzarini, I. Rosenberg and A. Holy, Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines, Antiviral Res. 8 (1987) 261–272; https://doi.org/10.1016/S0166-3542(87)80004-910.1016/S0166-3542(87)80004-9Search in Google Scholar

15. K. A. El-Sharkawy, N. N. E. El-Sayed and M. Y. Zaki, Uses of 2-amino-5,6-dihydro-4H-cyclopenta-[b]thiophene-3-carbonitrile in the synthesis of heterocyclic compounds with anticonvulsant, behavioral and CNS antidepressant activities, Int. Res. J. Pure Appl. Chem. 2 (2012) 91–104; https://doi.org/10.9734/IRJPAC/2012/122210.9734/IRJPAC/2012/1222Search in Google Scholar

16. M. Albratty, K. A. El-Sharkawy and M. S. Alam, Synthesis and antitumor activity of some novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives, Acta Pharm. 67 (2017) 15–33; https://doi.org/10.1515/acph-2017-000410.1515/acph-2017-0004Search in Google Scholar