<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Heart failure (HF) is a clinical status defined as a final stage of many cardiac diseases featured by severely impaired systolic myocardial performance in a result of dramatic decline in a number of properly functioning cardiomyocytes. Currently, the available therapeutic options for HF patients are not applicable in all of them. Up to now, many strategies to increase a number of normal cardiomyocytes have been proposed. One of them, the most physiological one at glance, seems to be a stimulation of post-mitotic cardiomyocytes to proliferate/or cardiac stem cells to differentiate. In this review article, detailed background of such method of myocardial regeneration, including the physiological processes of cardiomyocyte transformation and maturation, is presented. Moreover, the latest directions of basic research devoted to develop sufficient and safe cardiomyocyte-based therapies of the end-stage HF individuals are discussed. Concluding, this direction of further research seems to be justified particularly in a view of human population aging, an increased prevalence of HF and higher expectations of improved efficiency of patients’ care.</p>
</abstract>

Heart failure (HF) is a clinical status defined as a final stage of many cardiac diseases featured by severely impaired systolic myocardial performance in a result of dramatic decline in a number of properly functioning cardiomyocytes. Currently, the available therapeutic options for HF patients are not applicable in all of them. Up to now, many strategies to increase a number of normal cardiomyocytes have been proposed. One of them, the most physiological one at glance, seems to be a stimulation of post-mitotic cardiomyocytes to proliferate/or cardiac stem cells to differentiate. In this review article, detailed background of such method of myocardial regeneration, including the physiological processes of cardiomyocyte transformation and maturation, is presented. Moreover, the latest directions of basic research devoted to develop sufficient and safe cardiomyocyte-based therapies of the end-stage HF individuals are discussed. Concluding, this direction of further research seems to be justified particularly in a view of human population aging, an increased prevalence of HF and higher expectations of improved efficiency of patients’ care.

Current knowledge about cardiomyocytes maturation and endogenous myocardial regeneration. Background to apply this potential in humans with end-stage heart failure

Department of Cardiac Surgery and Transplantology

Student Scientific Group, English Division

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Heart failure (HF) is a clinical status defined as a final stage of many cardiac diseases featured by severely impaired systolic myocardial performance in a...

Current knowledge about cardiomyocytes maturation and endogenous myocardial regeneration. Background to apply this potential in humans with end-stage heart failure

Published Online: Dec 30, 2021

Page range: 153 - 159

Received: Oct 09, 2021

Accepted: Nov 15, 2021

DOI: https://doi.org/10.2478/acb-2021-0021

Keywords
heart failure, cardiomyocytes, transformation, maturation, myocardial regeneration

© 2021 Bartłomiej Perek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Current knowledge about cardiomyocytes maturation and endogenous myocardial regeneration. Background to apply this potential in humans with end-stage heart failure

Published Online: Dec 30, 2021

Page range: 153 - 159

Received: Oct 09, 2021

Accepted: Nov 15, 2021

DOI: https://doi.org/10.2478/acb-2021-0021

Keywordsheart failure, cardiomyocytes, transformation, maturation, myocardial regeneration

© 2021 Bartłomiej Perek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
heart failure, cardiomyocytes, transformation, maturation, myocardial regeneration