Cardiac Stem Cell Therapy, Resident Progenitor Cells and the role of Cellular Signalling; a Review
, , and | Nov 08, 2019
About this article
Published Online: Nov 08, 2019
Page range: 112 - 118
Received: Sep 12, 2019
Accepted: Oct 21, 2019
DOI: https://doi.org/10.2478/acb-2019-0015
Keywords
© 2019 Greg Hutchings, Mariusz J. Nawrocki, Paul Mozdziak, Bartosz Kempisty, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Summary of Distinct CPC populations. List of CPCs discovered, species cell type identified in, cell lineages associated with cell type, cellular markers defining unique cell type, literature used to gather information
| CPC POPULATION | SPECIES | ASSOCIATED CELL LINEAGES | CELLULAR MARKERS | REFERENCES |
|---|---|---|---|---|
| c-Kit+ | Human, mouse, rat, dog, pig | Endothelial | c-Kit+, CD34-, CD45-, Sca-1+, Abcg2+, CD105+, CD166+, GATA4+, NKX2-5+/-, MEF2c+ | [9] [47] |
| Sca-1+ | Mouse | Endothelial, Smooth muscle | Sca-1+, CD105+, CD34-, CD45-, FLK1-, c-Kit+/-, GATA4+, NKX2-5+/-, MEF2C+ | [9] [47] |
| Epicardium-deri- ved cells | Human, mouse | Mesenchymal, fibroblast, smooth muscle | CD34+, c-Kit+/-, CD44+, CD90+, CD105+, CD46+ | [9] [47] |
| Cardiosphere-de- rived cells | Human, mouse, rat, dog, pig | Cardiomyocytes, endothelial, smooth muscle | CD31+, CD34+, c-Kit(low), Sca1+, CD45+, CD105+, Abcg2+ | [9] [47] |
| Islet-1+ | Mouse, rat, human | Second heart field, Cardiac neural crest | Isl-1+, CD31-, Sca-1-, c-Kit+/-, GATA4+, NKX2-5+ | [9] [47] |
| Side Population Cells | Mouse, rat | Cardiomyocyte, fibroblast, endothelial, smooth muscle | CD34+, CD45+, Abcg2+, Sca-1+, c-Kit+, NKX2-5-, GATA4- | [9] [47] |
| Cardiac colony forming unit fibroblasts | Mouse | Mesenchymal | PDGFR-a+, Sca-1+, CD31-, CD90+, c-Kit(low), CD45-, FLK1-, CD44+, CD29+, CD105+ | [9] [47] |