Cardiac Stem Cell Therapy, Resident Progenitor Cells and the role of Cellular Signalling; a Review
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Nov 08, 2019
About this article
Published Online: Nov 08, 2019
Page range: 112 - 118
Received: Sep 12, 2019
Accepted: Oct 21, 2019
DOI: https://doi.org/10.2478/acb-2019-0015
Keywords
© 2019 Greg Hutchings, Mariusz J. Nawrocki, Paul Mozdziak, Bartosz Kempisty, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Summary of Distinct CPC populations_ List of CPCs discovered, species cell type identified in, cell lineages associated with cell type, cellular markers defining unique cell type, literature used to gather information
| CPC POPULATION | SPECIES | ASSOCIATED CELL LINEAGES | CELLULAR MARKERS | REFERENCES |
|---|---|---|---|---|
| c-Kit+ | Human, mouse, rat, dog, pig | Endothelial | c-Kit+, CD34-, CD45-, Sca-1+, Abcg2+, CD105+, CD166+, GATA4+, NKX2-5+/-, MEF2c+ | [9] [47] |
| Sca-1+ | Mouse | Endothelial, Smooth muscle | Sca-1+, CD105+, CD34-, CD45-, FLK1-, c-Kit+/-, GATA4+, NKX2-5+/-, MEF2C+ | [9] [47] |
| Epicardium-deri- ved cells | Human, mouse | Mesenchymal, fibroblast, smooth muscle | CD34+, c-Kit+/-, CD44+, CD90+, CD105+, CD46+ | [9] [47] |
| Cardiosphere-de- rived cells | Human, mouse, rat, dog, pig | Cardiomyocytes, endothelial, smooth muscle | CD31+, CD34+, c-Kit(low), Sca1+, CD45+, CD105+, Abcg2+ | [9] [47] |
| Islet-1+ | Mouse, rat, human | Second heart field, Cardiac neural crest | Isl-1+, CD31-, Sca-1-, c-Kit+/-, GATA4+, NKX2-5+ | [9] [47] |
| Side Population Cells | Mouse, rat | Cardiomyocyte, fibroblast, endothelial, smooth muscle | CD34+, CD45+, Abcg2+, Sca-1+, c-Kit+, NKX2-5-, GATA4- | [9] [47] |
| Cardiac colony forming unit fibroblasts | Mouse | Mesenchymal | PDGFR-a+, Sca-1+, CD31-, CD90+, c-Kit(low), CD45-, FLK1-, CD44+, CD29+, CD105+ | [9] [47] |