<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Polycystic Ovarian Syndrome (PCOS) is a disease that is characterized by an increased Gonadotropin-Releasing-Hormone (GnRH) pulsatile frequency, causing an altered LH/FSH ratio. More precisely an increased Luteinizing Hormone (LH) secretion compared to a decreased Follicle-Stimulating Hormone (FSH) secretion leads to the development of hyperandrogenism and to a low-level concentration of estrogens and therefore decreased negative estrogenic feedback in the control axis. The purpose of this review is to connect the physiological Hypothalamic-Pituitary-Ovarian (HPO) axis with said pathology and the ensuring discussion about the possible mechanisms of pathogenesis and guidelines for relieving associated symptoms.</p>
</abstract>

Polycystic Ovarian Syndrome (PCOS) is a disease that is characterized by an increased Gonadotropin-Releasing-Hormone (GnRH) pulsatile frequency, causing an altered LH/FSH ratio. More precisely an increased Luteinizing Hormone (LH) secretion compared to a decreased Follicle-Stimulating Hormone (FSH) secretion leads to the development of hyperandrogenism and to a low-level concentration of estrogens and therefore decreased negative estrogenic feedback in the control axis. The purpose of this review is to connect the physiological Hypothalamic-Pituitary-Ovarian (HPO) axis with said pathology and the ensuring discussion about the possible mechanisms of pathogenesis and guidelines for relieving associated symptoms.

Hormone Imbalance in Polycystic Ovarian Syndrome

George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş

Acta Biologica Marisiensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Hormone Imbalance in Polycystic Ovarian Syndrome"}

Polycystic Ovarian Syndrome (PCOS) is a disease that is characterized by an increased Gonadotropin-Releasing-Hormone (GnRH) pulsatile frequency, causing an...

Hormone Imbalance in Polycystic Ovarian Syndrome

Published Online: Jun 23, 2023

Page range: 10 - 20

Received: Feb 08, 2023

Accepted: Mar 19, 2023

DOI: https://doi.org/10.2478/abmj-2023-0002

Keywords
Polycystic Ovarian Syndrome, hyperandrogenism, hyperestrogenism, infertility, hirsutism

© 2023 Ivan Bergo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Hormone Imbalance in Polycystic Ovarian Syndrome

Published Online: Jun 23, 2023

Page range: 10 - 20

Received: Feb 08, 2023

Accepted: Mar 19, 2023

DOI: https://doi.org/10.2478/abmj-2023-0002

KeywordsPolycystic Ovarian Syndrome, hyperandrogenism, hyperestrogenism, infertility, hirsutism

© 2023 Ivan Bergo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Polycystic Ovarian Syndrome, hyperandrogenism, hyperestrogenism, infertility, hirsutism