<abstract xmlns="http://www.w3.org/1999/xhtml">

The demand for medicinal plants and their derived substances is increasing day by day due to their relevance in the context of drug discovery and development. The goal of this investigation is to assess the pharmacological and phytochemical potentials of the grossly underexplored <italic>Antidesma montanum</italic> Blume (Family: Phyllanthaceae). The methanolic extract of the leave of this plant was fractionated and then followed by initial screening of phytochemical. The investigation of the pharmacological potential, which includes antioxidant, antidiarrheal, anti-inflammatory, analgesic, anti-pyretic, and anxiolytic evaluations, was accomplished using an <italic>in vitro</italic> free radical scavenging assay with 2,2-diphenyl-1-picrylhydrazyl (DPPH), castor oil-induced diarrheal test, egg albumin test, acetic acid-induced writhing model, brewer’s yeast induced fever test, swing test, open field, and light-dark test, respectively. The investigation o phytochemicals proposes that the methanol extract of <italic>A. montanum</italic> possesses flavonoids, tannins, terpenoids, saponins, amino acids, fixed oils, and sterols. Pharmacological evaluation suggests that <italic>A. montanum</italic> possesses significant antioxidant, anti-diarrheal, anti-inflammatory, and analgesic effects. The methanol and chloroform fractions exhibited better DPPH radical scavenging activities with an IC50: 103 ± 0.05 and 108.7 ± 0.05 µg/ml, respectively. The methanol and chloroform fractions also showed anti-inflammatory capacities in the egg albumin (IC50 values: 89.10 ± 0.07 and 92.85 ± 0.07 µg/ml, respectively) model. The plant also showed anti-pyretic and anxiolytic activities in a dose-dependent manner. One of the possible sources of phytotherapeutic lead compounds is <italic>A. montanum</italic>. To extract and analyze the key bioactive components of this essential therapeutic plant, more research is required.
</abstract>

The demand for medicinal plants and their derived substances is increasing day by day due to their relevance in the context of drug discovery and development. The goal of this investigation is to assess the pharmacological and phytochemical potentials of the grossly underexplored Antidesma montanum Blume (Family: Phyllanthaceae). The methanolic extract of the leave of this plant was fractionated and then followed by initial screening of phytochemical. The investigation of the pharmacological potential, which includes antioxidant, antidiarrheal, anti-inflammatory, analgesic, anti-pyretic, and anxiolytic evaluations, was accomplished using an in vitro free radical scavenging assay with 2,2-diphenyl-1-picrylhydrazyl (DPPH), castor oil-induced diarrheal test, egg albumin test, acetic acid-induced writhing model, brewer’s yeast induced fever test, swing test, open field, and light-dark test, respectively. The investigation o phytochemicals proposes that the methanol extract of A. montanum possesses flavonoids, tannins, terpenoids, saponins, amino acids, fixed oils, and sterols. Pharmacological evaluation suggests that A. montanum possesses significant antioxidant, anti-diarrheal, anti-inflammatory, and analgesic effects. The methanol and chloroform fractions exhibited better DPPH radical scavenging activities with an IC50: 103 ± 0.05 and 108.7 ± 0.05 µg/ml, respectively. The methanol and chloroform fractions also showed anti-inflammatory capacities in the egg albumin (IC50 values: 89.10 ± 0.07 and 92.85 ± 0.07 µg/ml, respectively) model. The plant also showed anti-pyretic and anxiolytic activities in a dose-dependent manner. One of the possible sources of phytotherapeutic lead compounds is A. montanum. To extract and analyze the key bioactive components of this essential therapeutic plant, more research is required.

Phytochemical Evaluation and Pharmacological Activities of <italic>Antidesma Montanum</italic> Blume Leaf Extract

Department of Pharmacy, Life Science Faculty

Bangabandhu Sheikh Mujibur Rahman Science and Technology University

Acta Biologica Marisiensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Phytochemical Evaluation and Pharmacological Activities of  Blume Leaf Extract

The demand for medicinal plants and their derived substances is increasing day by day due to their relevance in the context of drug discovery and development....

Phytochemical Evaluation and Pharmacological Activities of Antidesma Montanum Blume Leaf Extract

Published Online: Jul 09, 2022

Page range: 1 - 16

Received: Mar 31, 2022

Accepted: Apr 10, 2022

DOI: https://doi.org/10.2478/abmj-2022-0001

Keywords
phytochemicals, pharmacological activities

© 2022 Farhana Zaman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Phytochemical Evaluation and Pharmacological Activities of Antidesma Montanum Blume Leaf Extract

Published Online: Jul 09, 2022

Page range: 1 - 16

Received: Mar 31, 2022

Accepted: Apr 10, 2022

DOI: https://doi.org/10.2478/abmj-2022-0001

Keywordsphytochemicals, pharmacological activities

© 2022 Farhana Zaman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
phytochemicals, pharmacological activities