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Neonatal sevoflurane anesthesia can also affect rat medulla spinalis

Elvan Ocmen

Elvan Ocmen

Department of Anesthesia, Dokuz Eylul University HospitalIzmir, Turkey
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Ocmen, Elvan
, 
Hale Aksu Erdost

Hale Aksu Erdost

Department of Anesthesia, Dokuz Eylul University HospitalIzmir, Turkey
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Erdost, Hale Aksu
, 
Osman Yilmaz

Osman Yilmaz

Department of Anesthesia, Dokuz Eylul University School of Health SciencesIzmir, Turkey
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Yilmaz, Osman
, 
Alper Bagriyanik

Alper Bagriyanik

Department of Histology and Embryology, Dokuz Eylul University HospitalIzmir, Turkey
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Bagriyanik, Alper
, 
Muge Kiray

Muge Kiray

Department of Physiology, Dokuz Eylul UniversityIzmir, Turkey
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Kiray, Muge
 and 
Necati Gokmen

Necati Gokmen

Department of Anesthesia, Dokuz Eylul University HospitalIzmir, Turkey
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Gokmen, Necati
  
Jun 30, 2025
Neonatal sevoflurane anesthesia can also affect rat medulla spinalis's Cover Image
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Article Category: Original article
Published Online: Jun 30, 2025
Page range: 141 - 146
DOI: https://doi.org/10.2478/abm-2025-0017
Keywords
© 2025 Elvan Ocmen et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1.

Crystal violet-stained sections of the rat spinal cords. (A) acute control, (B) chronic control, (C) acute sevoflurane, and (D) chronic sevoflurane groups. Arrows showing pyknotic cells. Bars = 50 μm.
Crystal violet-stained sections of the rat spinal cords. (A) acute control, (B) chronic control, (C) acute sevoflurane, and (D) chronic sevoflurane groups. Arrows showing pyknotic cells. Bars = 50 μm.

Figure 2.

TUNEL staining. Representative photomicrographs of TUNEL-positive cells (arrows). (A) acute control, (B) chronic control, (C) acute sevoflurane, and (D) chronic sevoflurane groups. Bars = 50 μm.
TUNEL staining. Representative photomicrographs of TUNEL-positive cells (arrows). (A) acute control, (B) chronic control, (C) acute sevoflurane, and (D) chronic sevoflurane groups. Bars = 50 μm.

Results of 8th, 15th, and 30th days tail flick tests of control and sevoflurane groups

8th day 15th day 30th day
Control group 9.40 (7–14.9) 10.70 (7.7–14.9) 9.30 (6.3–13.7)*
Sevoflurane group 9.40 (4.2–14.9) 11.35 (6.0–14.9) 5.95 (3.8–10.2)*

The percentage of TUNEL-positive cells of ACont, ASevo, CCont, and CSevo groups

Groups n TUNEL (%) (Mean ± SEM)
ACont 6 4.28 ± 0.68
ASevo 6 9.85 ± 0.50
CCont 6 5.00 ± 0.65
CSevo 6 19.14 ± 2.81†
P (ACont vs. CSevo) <0.001*
P (ASevo vs. CSevo) 0.001*
P (CCont vs. CSevo) <0.001*
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