2024 The Royal College of Physicians of Thailand (RCPT) clinical practice guidelines on management of dyslipidemia for atherosclerotic cardiovascular disease prevention
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Thongtang N, Sukmawan R, Llanes EJB, Lee ZV. Dyslipidemia management for primary prevention of cardiovascular events: best in-clinic practices. Prev Med Rep. 2022; 27:101819.ThongtangNSukmawanRLlanesEJBLeeZVDyslipidemia management for primary prevention of cardiovascular events: best in-clinic practicesPrev Med Rep.202227101819Search in Google Scholar
Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020; 41:111–88.MachFBaigentCCatapanoALKoskinasKCCasulaMBadimonL2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular riskEur Heart J.20204111188Search in Google Scholar
Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2017; 38:2459–72.FerenceBAGinsbergHNGrahamIRayKKPackardCJBruckertELow-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus PanelEur Heart J.201738245972Search in Google Scholar
Gidding SS, Allen NB. Cholesterol and atherosclerotic cardiovascular disease: a lifelong problem. J Am Heart Assoc. 2019; 8:e012924. doi: 10.1161/JAHA.119.012924GiddingSSAllenNBCholesterol and atherosclerotic cardiovascular disease: a lifelong problemJ Am Heart Assoc.20198e01292410.1161/JAHA.119.012924Open DOISearch in Google Scholar
Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023; 44:3720–826.ByrneRARosselloXCoughlanJJBarbatoEBerryCChieffoA2023 ESC Guidelines for the management of acute coronary syndromesEur Heart J.2023443720826Search in Google Scholar
Ray KK, Ference BA, Séverin T, Blom D, Nicholls SJ, Shiba MH, et al. World Heart Federation Cholesterol Roadmap 2022. Glob Heart. 2022; 17:75. doi: 10.5334/gh.1154RayKKFerenceBASéverinTBlomDNichollsSJShibaMHWorld Heart Federation Cholesterol Roadmap 2022Glob Heart.2022177510.5334/gh.1154Open DOISearch in Google Scholar
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Circulation. 2019; 139:e1082–143.GrundySMStoneNJBaileyALBeamCBirtcherKKBlumenthalRS2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelinesCirculation.2019139e1082143Search in Google Scholar
Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Bäck M, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021; 42:3227–337.VisserenFLJMachFSmuldersYMCarballoDKoskinasKCBäckM2021 ESC Guidelines on cardiovascular disease prevention in clinical practiceEur Heart J.2021423227337Search in Google Scholar
Cholesterol Treatment Trialists' (CTT) Collaboration, Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010; 376:1670–81.Cholesterol Treatment Trialists' (CTT) CollaborationBaigentCBlackwellLEmbersonJHollandLEReithCEfficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trialsLancet.2010376167081Search in Google Scholar
Vathesatogkit P, Woodward M, Tanomsup S, Ratanachaiwong W, Vanavanan S, Yamwong S, et al. Cohort profile: the electricity generating authority of Thailand study. Int J Epidemiol. 2012; 41:359–65.VathesatogkitPWoodwardMTanomsupSRatanachaiwongWVanavananSYamwongSCohort profile: the electricity generating authority of Thailand studyInt J Epidemiol.20124135965Search in Google Scholar
Guidelines Review Committee, Nutrition and Food Safety (NFS), SEARO Regional Office for the South East Asia (RGO), WHO South-East Asia. Guideline: sugars intake for adults and children2015. Available from: https://www.who.int/publications/i/item/9789241549028Guidelines Review Committee, Nutrition and Food Safety (NFS), SEARO Regional Office for the South East Asia (RGO)WHO South-East AsiaGuideline: sugars intake for adults and children2015. Available from: https://www.who.int/publications/i/item/9789241549028Search in Google Scholar
Chiavaroli L, Viguiliouk E, Nishi SK, Blanco Mejia S, Rahelić D, Kahleová H, et al. DASH dietary pattern and cardiometabolic outcomes: an umbrella review of systematic reviews and meta-analyses. Nutrients. 2019; 11:338. doi: 10.3390/nu11020338ChiavaroliLViguilioukENishiSKBlanco MejiaSRahelićDKahleováHDASH dietary pattern and cardiometabolic outcomes: an umbrella review of systematic reviews and meta-analysesNutrients20191133810.3390/nu11020338Open DOISearch in Google Scholar
Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS, et al. 2013 AHA/ACC Guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129(25 Suppl 2):S76–99.EckelRHJakicicJMArdJDde JesusJMHouston MillerNHubbardVS2013 AHA/ACC Guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesCirculation201412925 Suppl 2S7699Search in Google Scholar
Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, et al. Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts. N Engl J Med. 2018; 378:e34. doi: 10.1056/NEJMoa1800389EstruchRRosESalas-SalvadóJCovasMICorellaDArósFPrimary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nutsN Engl J Med.2018378e3410.1056/NEJMoa1800389Open DOISearch in Google Scholar
Handelsman Y, Jellinger PS, Guerin CK, Bloomgarden ZT, Brinton EA, Budoff MJ, et al. Consensus statement by the American Association of clinical endocrinologists and American College of Endocrinology on the management of dyslipidemia and prevention of cardiovascular disease algorithm – 2020 executive summary. Endocr Pract. 2020; 26:1196–224.HandelsmanYJellingerPSGuerinCKBloomgardenZTBrintonEABudoffMJConsensus statement by the American Association of clinical endocrinologists and American College of Endocrinology on the management of dyslipidemia and prevention of cardiovascular disease algorithm – 2020 executive summaryEndocr Pract.2020261196224Search in Google Scholar
Authors/Task Force Members, ESC Committee for Practice Guidelines (CPG), ESC National Cardiac Societies. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Atherosclerosis. 2019; 290:140–205.Authors/Task Force Members, ESC Committee for Practice Guidelines (CPG), ESC National Cardiac Societies2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular riskAtherosclerosis.2019290140205Search in Google Scholar
Berglund L, Lefevre M, Ginsberg HN, Kris-Etherton PM, Elmer PJ, Stewart PW, et al. Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states. Am J Clin Nutr. 2007; 86:1611–20.BerglundLLefevreMGinsbergHNKris-EthertonPMElmerPJStewartPWComparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial statesAm J Clin Nutr.200786161120Search in Google Scholar
Ginsberg HN, Kris-Etherton P, Dennis B, Elmer PJ, Ershow A, Lefevre M, et al. Effects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in healthy subjects: the DELTA Study, protocol 1. Arterioscler Thromb Vasc Biol. 1998; 18:441–9.GinsbergHNKris-EthertonPDennisBElmerPJErshowALefevreMEffects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in healthy subjects: the DELTA Study, protocol 1Arterioscler Thromb Vasc Biol.1998184419Search in Google Scholar
Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr. 2003; 77:1146–55.MensinkRPZockPLKesterADKatanMBEffects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trialsAm J Clin Nutr.200377114655Search in Google Scholar
Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr. 1999; 69:30–42.BrownLRosnerBWillettWWSacksFMCholesterol-lowering effects of dietary fiber: a meta-analysisAm J Clin Nutr.1999693042Search in Google Scholar
Hollaender PL, Ross AB, Kristensen M. Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies. Am J Clin Nutr. 2015; 102:556–72.HollaenderPLRossABKristensenMWhole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studiesAm J Clin Nutr.201510255672Search in Google Scholar
Gylling H, Plat J, Turley S, Ginsberg HN, Ellegård L, Jessup W, et al. Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis. 2014; 232:346–60.GyllingHPlatJTurleySGinsbergHNEllegårdLJessupWPlant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular diseaseAtherosclerosis.201423234660Search in Google Scholar
Musa-Veloso K, Poon TH, Elliot JA, Chung C. A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2011; 85:9–28.Musa-VelosoKPoonTHElliotJAChungCA comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trialsProstaglandins Leukot Essent Fatty Acids.201185928Search in Google Scholar
Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ. 1999; 319:1523–8.RimmEBWilliamsPFosherKCriquiMStampferMJModerate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factorsBMJ.199931915238Search in Google Scholar
Gardner CD, Kraemer HC. Monounsaturated versus polyunsaturated dietary fat and serum lipids. A meta-analysis. Arterioscler Thromb Vasc Biol. 1995; 15:1917–27.GardnerCDKraemerHCMonounsaturated versus polyunsaturated dietary fat and serum lipids. A meta-analysisArterioscler Thromb Vasc Biol.199515191727Search in Google Scholar
Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WS Jr, Brehm BJ, et al. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006; 166:285–93.NordmannAJNordmannABrielMKellerUYancyWSJrBrehmBJEffects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trialsArch Intern Med.200616628593Search in Google Scholar
Santos FL, Esteves SS, da Costa Pereira A, Yancy WS Jr, Nunes JP. Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors. Obes Rev. 2012; 13:1048–66.SantosFLEstevesSSda Costa PereiraAYancyWSJrNunesJPSystematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factorsObes Rev.201213104866Search in Google Scholar
Kelishadi R, Mansourian M, Heidari-Beni M. Association of fructose consumption and components of metabolic syndrome in human studies: a systematic review and meta-analysis. Nutrition. 2014; 30:503–10.KelishadiRMansourianMHeidari-BeniMAssociation of fructose consumption and components of metabolic syndrome in human studies: a systematic review and meta-analysisNutrition.20143050310Search in Google Scholar
Rouis M, Dugi KA, Previato L, Patterson AP, Brunzell JD, Brewer HB, et al. Therapeutic response to medium-chain triglycerides and omega-3 fatty acids in a patient with the familial chylomicronemia syndrome. Arterioscler Thromb Vasc Biol. 1997; 17:1400–6.RouisMDugiKAPreviatoLPattersonAPBrunzellJDBrewerHBTherapeutic response to medium-chain triglycerides and omega-3 fatty acids in a patient with the familial chylomicronemia syndromeArterioscler Thromb Vasc Biol.19971714006Search in Google Scholar
Shirai K, Kobayashi J, Inadera H, Ohkubo Y, Mori S, Saito Y, et al. Type I hyperlipoproteinemia caused by lipoprotein lipase defect in lipid-interface recognition was relieved by administration of medium-chain triglyceride. Metabolism. 1992; 41:1161–4.ShiraiKKobayashiJInaderaHOhkuboYMoriSSaitoYType I hyperlipoproteinemia caused by lipoprotein lipase defect in lipid-interface recognition was relieved by administration of medium-chain triglycerideMetabolism.19924111614Search in Google Scholar
Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports Med. 2014; 44:211–21.MannSBeedieCJimenezADifferential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendationsSports Med.20144421121Search in Google Scholar
Shaw K, Gennat H, O'Rourke P, Del Mar C. Exercise for overweight or obesity. Cochrane Database Syst Rev. 2006; 2006:CD003817.ShawKGennatHO'RourkePDel MarCExercise for overweight or obesityCochrane Database Syst Rev.20062006:CD003817Search in Google Scholar
Maeda K, Noguchi Y, Fukui T. The effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysis. Prev Med. 2003; 37:283–90.MaedaKNoguchiYFukuiTThe effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysisPrev Med.20033728390Search in Google Scholar
Chou R, Cantor A, Dana T, Wagner J, Ahmed AY, Fu R, et al. Statin use for the primary prevention of cardiovascular disease in adults: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2022; 328:754–71.ChouRCantorADanaTWagnerJAhmedAYFuRStatin use for the primary prevention of cardiovascular disease in adults: updated evidence report and systematic review for the US Preventive Services Task ForceJAMA202232875471Search in Google Scholar
Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008; 359:2195–207.RidkerPMDanielsonEFonsecaFAGenestJGottoAMJrKasteleinJJRosuvastatin to prevent vascular events in men and women with elevated C-reactive proteinN Engl J Med.20083592195207Search in Google Scholar
Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013; 2013:CD004816. doi: 10.1002/14651858.CD004816.pub5TaylorFHuffmanMDMacedoAFMooreTHBurkeMDavey SmithGStatins for the primary prevention of cardiovascular diseaseCochrane Database Syst Rev.20132013:CD00481610.1002/14651858.CD004816.pub5Open DOISearch in Google Scholar
Yusuf S, Bosch J, Dagenais G, Zhu J, Xavier D, Liu L, et al. Cholesterol lowering in intermediate-risk persons without cardiovascular disease. N Engl J Med. 2016; 374:2021–31.YusufSBoschJDagenaisGZhuJXavierDLiuLCholesterol lowering in intermediate-risk persons without cardiovascular diseaseN Engl J Med.2016374202131Search in Google Scholar
Han BH, Sutin D, Williamson JD, Davis BR, Piller LB, Pervin H, et al. Effect of statin treatment vs usual care on primary cardiovascular prevention among older adults: the ALLHAT-LLT randomized clinical trial. JAMA Intern Med. 2017; 177:955–65.HanBHSutinDWilliamsonJDDavisBRPillerLBPervinHEffect of statin treatment vs usual care on primary cardiovascular prevention among older adults: the ALLHAT-LLT randomized clinical trialJAMA Intern Med.201717795565Search in Google Scholar
Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. 2002; 360:1623–30.ShepherdJBlauwGJMurphyMBBollenELBuckleyBMCobbeSMPravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trialLancet.2002360162330Search in Google Scholar
Naci H, Brugts JJ, Fleurence R, Tsoi B, Toor H, Ades AE. Comparative benefits of statins in the primary and secondary prevention of major coronary events and all-cause mortality: a network meta-analysis of placebo-controlled and active-comparator trials. Eur J Prev Cardiol. 2013; 20:641–57.NaciHBrugtsJJFleurenceRTsoiBToorHAdesAEComparative benefits of statins in the primary and secondary prevention of major coronary events and all-cause mortality: a network meta-analysis of placebo-controlled and active-comparator trialsEur J Prev Cardiol.20132064157Search in Google Scholar
Nowak MM, Niemczyk M, Florczyk M, Kurzyna M, Paczek L. Effect of statins on all-cause mortality in adults: a systematic review and meta-analysis of propensity score-matched studies. J Clin Med. 2022; 11:5643. doi: 10.3390/jcm11195643NowakMMNiemczykMFlorczykMKurzynaMPaczekLEffect of statins on all-cause mortality in adults: a systematic review and meta-analysis of propensity score-matched studiesJ Clin Med.202211564310.3390/jcm11195643Open DOISearch in Google Scholar
Bruckert E, Hayem G, Dejager S, Yau C, Begaud B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients – the PRIMO study. Cardiovasc Drugs Ther. 2005; 19:403–14.BruckertEHayemGDejagerSYauCBegaudBMild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients – the PRIMO studyCardiovasc Drugs Ther.20051940314Search in Google Scholar
Gupta A, Thompson D, Whitehouse A, Collier T, Dahlof B, Poulter N, et al. Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase. Lancet. 2017; 389:2473–81.GuptaAThompsonDWhitehouseACollierTDahlofBPoulterNAdverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phaseLancet.2017389247381Search in Google Scholar
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA Guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Circulation. 2019; 140:e563–95.ArnettDKBlumenthalRSAlbertMABurokerABGoldbergerZDHahnEJ2019 ACC/AHA Guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelinesCirculation2019140e56395Search in Google Scholar
ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. 10. cardiovascular disease and risk management: standards of care in diabetes-2023. Diabetes Care. 2023; 46(Suppl 1):S158–90.ElSayedNAAleppoGArodaVRBannuruRRBrownFMBruemmerD10. cardiovascular disease and risk management: standards of care in diabetes-2023Diabetes Care202346Suppl 1S15890Search in Google Scholar
Wright AK, Suarez-Ortegon MF, Read SH, Kontopantelis E, Buchan I, Emsley R, et al. Risk factor control and cardiovascular event risk in people with type 2 diabetes in primary and secondary prevention settings. Circulation. 2020; 142:1925–36.WrightAKSuarez-OrtegonMFReadSHKontopantelisEBuchanIEmsleyRRisk factor control and cardiovascular event risk in people with type 2 diabetes in primary and secondary prevention settingsCirculation.2020142192536Search in Google Scholar
ACCORD Study Group, Ginsberg HN, Elam MB, Lovato LC, Crouse JR 3rd, Leiter LA, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010; 362:1563–74.ACCORD Study GroupGinsbergHNElamMBLovatoLCCrouseJR3rdLeiterLAEffects of combination lipid therapy in type 2 diabetes mellitusN Engl J Med.2010362156374Search in Google Scholar
AIM-HIGH Investigators, Boden WE, Probstfield JL, Anderson T, Chaitman BR, Desvignes-Nickens P, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011; 365:2255–67.AIM-HIGH InvestigatorsBodenWEProbstfieldJLAndersonTChaitmanBRDesvignes-NickensPNiacin in patients with low HDL cholesterol levels receiving intensive statin therapyN Engl J Med.2011365225567Search in Google Scholar
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019; 380:11–22.BhattDLStegPGMillerMBrintonEAJacobsonTAKetchumSBCardiovascular risk reduction with icosapent ethyl for hypertriglyceridemiaN Engl J Med.20193801122Search in Google Scholar
Kidney Disease: Improving Global Outcomes (KDIGO) Lipid Work Group. KDIGO clinical practice guideline for lipid management in chronic kidney disease. Kidney Inter Suppl. 2013; 3:259–305.Kidney Disease: Improving Global Outcomes (KDIGO) Lipid Work GroupKDIGO clinical practice guideline for lipid management in chronic kidney disease.Kidney Inter Suppl.20133259305Search in Google Scholar
Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet. 2011; 377:2181–92.BaigentCLandrayMJReithCEmbersonJWheelerDCTomsonCThe effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trialLancet.2011377218192Search in Google Scholar
Cholesterol Treatment Trialists' (CTT) Collaboration, Herrington WG, Emberson J, Mihaylova B, Blackwell L, Reith C, et al. Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials. Lancet Diabetes Endocrinol. 2016; 4:829–39.Cholesterol Treatment Trialists' (CTT) CollaborationHerringtonWGEmbersonJMihaylovaBBlackwellLReithCImpact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trialsLancet Diabetes Endocrinol.2016482939Search in Google Scholar
Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020; 41:407–77.KnuutiJWijnsWSarasteACapodannoDBarbatoEFunck-BrentanoC2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromesEur Heart J.20204140777Search in Google Scholar
Amarenco P, Bogousslavsky J, Callahan A 3rd, Goldstein LB, Hennerici M, Rudolph AE, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006; 355:549–59.AmarencoPBogousslavskyJCallahanA3rdGoldsteinLBHennericiMRudolphAEHigh-dose atorvastatin after stroke or transient ischemic attackN Engl J Med.200635554959Search in Google Scholar
Callahan A, Amarenco P, Goldstein LB, Sillesen H, Messig M, Samsa GP, et al. Risk of stroke and cardiovascular events after ischemic stroke or transient ischemic attack in patients with type 2 diabetes or metabolic syndrome: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Arch Neurol. 2011; 68:1245–51.CallahanAAmarencoPGoldsteinLBSillesenHMessigMSamsaGPRisk of stroke and cardiovascular events after ischemic stroke or transient ischemic attack in patients with type 2 diabetes or metabolic syndrome: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trialArch Neurol.201168124551Search in Google Scholar
Kleindorfer DO, Towfighi A, Chaturvedi S, Cockroft KM, Gutierrez J, Lombardi-Hill D, et al. 2021 Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke. 2021; 52:e364–467.KleindorferDOTowfighiAChaturvediSCockroftKMGutierrezJLombardi-HillD2021 Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke AssociationStroke202152e364467Search in Google Scholar
Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, et al. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015; 372:2387–97.CannonCPBlazingMAGiuglianoRPMcCaggAWhiteJATherouxPEzetimibe added to statin therapy after acute coronary syndromesN Engl J Med.2015372238797Search in Google Scholar
Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. N Engl J Med. 2017; 376:1713–22.SabatineMSGiuglianoRPKeechACHonarpourNWiviottSDMurphySAEvolocumab and clinical outcomes in patients with cardiovascular diseaseN Engl J Med.2017376171322Search in Google Scholar
Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, et al. Alirocumab and cardiovascular outcomes after acute coronary syndrome. N Engl J Med. 2018; 379:2097–107.SchwartzGGStegPGSzarekMBhattDLBittnerVADiazRAlirocumab and cardiovascular outcomes after acute coronary syndromeN Engl J Med.20183792097107Search in Google Scholar
Eun MY, Jung JM, Choi KH, Seo WK. Statin effects in atrial fibrillation-related stroke: a systematic review and meta-analysis. Front Neurol. 2020; 11:589684. doi: 10.3389/fneur.2020.589684EunMYJungJMChoiKHSeoWKStatin effects in atrial fibrillation-related stroke: a systematic review and meta-analysisFront Neurol.20201158968410.3389/fneur.2020.589684Open DOISearch in Google Scholar
Goldstein LB, Toth PP, Dearborn-Tomazos JL, Giugliano RP, Hirsh BJ, Peña JM, et al. Aggressive LDL-C lowering and the brain: impact on risk for dementia and hemorrhagic stroke: a scientific statement from the American Heart Association. Arterioscler Thromb Vasc Biol. 2023; 43:e404–42.GoldsteinLBTothPPDearborn-TomazosJLGiuglianoRPHirshBJPeñaJMAggressive LDL-C lowering and the brain: impact on risk for dementia and hemorrhagic stroke: a scientific statement from the American Heart AssociationArterioscler Thromb Vasc Biol.202343e40442Search in Google Scholar
Greenberg SM, Ziai WC, Cordonnier C, Dowlatshahi D, Francis B, Goldstein JN, et al. 2022 Guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2022; 53:e282–361.GreenbergSMZiaiWCCordonnierCDowlatshahiDFrancisBGoldsteinJN2022 Guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke AssociationStroke202253e282361Search in Google Scholar
Keech A, Simes RJ, Barter P, Best J, Scott R, Taskinen MR, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet. 2005; 366:1849–61.KeechASimesRJBarterPBestJScottRTaskinenMREffects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trialLancet.2005366184961Search in Google Scholar
ACCORD Study Group, ACCORD Eye Study Group, Chew EY, Ambrosius WT, Davis MD, Danis RP, et al. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med. 2010; 363:233–44.ACCORD Study Group, ACCORD Eye Study GroupChewEYAmbrosiusWTDavisMDDanisRPEffects of medical therapies on retinopathy progression in type 2 diabetesN Engl J Med.201036323344Search in Google Scholar
Keech AC, Mitchell P, Summanen PA, O'Day J, Davis TM, Moffitt MS, et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet. 2007; 370:1687–97.KeechACMitchellPSummanenPAO'DayJDavisTMMoffittMSEffect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trialLancet.2007370168797Search in Google Scholar
Ray KK, Raal FJ, Kallend DG, Jaros MJ, Koenig W, Leiter LA, et al. Inclisiran and cardiovascular events: a patient-level analysis of phase III trials. Eur Heart J. 2023; 44:129–38.RayKKRaalFJKallendDGJarosMJKoenigWLeiterLAInclisiran and cardiovascular events: a patient-level analysis of phase III trialsEur Heart J.20234412938Search in Google Scholar
Nissen SE, Lincoff AM, Brennan D, Ray KK, Mason D, Kastelein JJP, et al. Bempedoic acid and cardiovascular outcomes in statin-intolerant patients. N Engl J Med. 2023; 388:1353–64.NissenSELincoffAMBrennanDRayKKMasonDKasteleinJJPBempedoic acid and cardiovascular outcomes in statin-intolerant patientsN Engl J Med.2023388135364Search in Google Scholar
Nicholls SJ, Lincoff AM, Garcia M, Bash D, Ballantyne CM, Barter PJ, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA. 2020; 324:2268–80.NichollsSJLincoffAMGarciaMBashDBallantyneCMBarterPJEffect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trialJAMA.2020324226880Search in Google Scholar
The Lipid Research Clinics Coronary Primary Prevention Trial Results. I. Reduction in incidence of coronary heart disease. JAMA. 1984; 251:351–64.The Lipid Research Clinics Coronary Primary Prevention Trial Results. I. Reduction in incidence of coronary heart diseaseJAMA.198425135164Search in Google Scholar
Jellinger PS, Handelsman Y, Rosenblit PD, Bloomgarden ZT, Fonseca VA, Garber AJ, et al. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for management of dyslipidemia and prevention of cardiovascular disease. Endocr Pract. 2017; 23(Suppl 2):1–87.JellingerPSHandelsmanYRosenblitPDBloomgardenZTFonsecaVAGarberAJAmerican Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for management of dyslipidemia and prevention of cardiovascular diseaseEndocr Pract.201723Suppl 2187Search in Google Scholar
Newman CB, Blaha MJ, Boord JB, Cariou B, Chait A, Fein HG, et al. Lipid management in patients with endocrine disorders: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2020; 105:dgaa674. doi: 10.1210/clinem/dgaa674NewmanCBBlahaMJBoordJBCariouBChaitAFeinHGLipid management in patients with endocrine disorders: an Endocrine Society clinical practice guidelineJ Clin Endocrinol Metab.2020105dgaa674.10.1210/clinem/dgaa674Open DOISearch in Google Scholar
Marx N, Federici M, Schütt K, Müller-Wieland D, Ajjan RA, Antunes MJ, et al. 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes. Eur Heart J. 2023; 44:4043–140.MarxNFedericiMSchüttKMüller-WielandDAjjanRAAntunesMJ2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetesEur Heart J.2023444043140Search in Google Scholar
Budoff M, Brent Muhlestein J, Le VT, May HT, Roy S, Nelson JR. Effect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200–499 mg/dL) on statin therapy: rationale and design of the EVAPORATE study. Clin Cardiol. 2018; 41:13–9.BudoffMBrent MuhlesteinJLeVTMayHTRoySNelsonJREffect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200–499 mg/dL) on statin therapy: rationale and design of the EVAPORATE studyClin Cardiol.201841139Search in Google Scholar