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Predictive model for left main coronary artery or triple vessel disease in patients with chronic coronary syndromes

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Sep 20, 2024

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Figure 1.

ROC curve of the prediction score. ROC, receiver operating characteristic.
ROC curve of the prediction score. ROC, receiver operating characteristic.

Multivariate logistic regression of the study population

Predictors Univariate analyses Multivariate analyses


OR (95% CI) P OR (95% CI) P
Age (years) 1.035 (1.01–1.06) 0.02* 1.03 (0.99–1.08) 0.16
eGFR 0.99 (0.97–0.999) 0.04* 1.02 (1.00–1.05) 0.09
New onset of HF or LVSD and suspected CAD 4.09 (2.02–8.28) <0.01* 3.04 (1.23–7.50) 0.02*
Number of leads having STD 1.59 (1.35–1.87) <0.01* 0.77 (0.41–1.42) 0.40
Summation of leads having STD 28.74 (8.26–99.97) <0.01* 1.99 (0.05–73.80) 0.71
STE in aVR 12.32 (4.84–31.36) <0.01* 5.56 (1.40–22.16) 0.02*
STE in V1 5.60 (2.70–11.65) <0.01* 3.48 (1.37–8.88) 0.01*
Anterior STD 3.47 (0.93–12.96) 0.06 2.32 (0.30–18.28) 0.42
Lateral STD 14.67 (6.42–33.53) <0.01* 8.41 (1.51–46.88) 0.02*
Inferior STD 3.21 (1.21–8.54) 0.02* 1.05 (0.20–5.63) 0.96

The prediction scores

Predictors Point
New onset of HF or LVSD and suspected CAD 1
STE in V1 1
STE in aVR 2
Lateral STD 3

Baseline characteristics of the patients

Demographic data All patients (n = 162) Non-LMCAD/TVD (n = 75) LMCAD/TVD (n = 87) P
Age (years), Mean ± SD 66.1 ± 11.5 63.7 ± 10.8 68.1 ± 11.8 0.02*
Male sex, n (%) 91 (56.2) 43 (57.3) 48 (55.2) 0.78
eGFR, Mean ± SD 72.88 ± 21.98 76.68 ± 22.17 69.60 ± 21.40 0.04*
LVEF (%), Mean ± SD 56.1 ± 16.3 59.8 ± 14.3 53.0 ± 17.3 <0.01*
New onset of HF or LVSD and suspected CAD 59 (36.4) 15 (20.0) 44 (50.6) <0.01*
Medical history, n (%)
  Diabetes mellitus 77 (47.5) 31 (41.3) 46 (52.9) 0.14
  Hypertension 135 (83.3) 60 (80.0) 75 (86.2) 0.29
  Dyslipidemia 135 (83.3) 61 (81.3) 74 (85.1) 0.53
  Obesity 79 (48.8) 41 (54.7) 38 (43.7) 0.16
  History of HF 47 (29.0) 13 (17.3) 34 (39.1) <0.01*
  Previous MI 108 (66.7) 42 (56.0) 66 (75.9) <0.01*
  Prior PCI 64 (39.5) 29 (38.7) 35 (40.2) 0.84
  Prior CABG 9 (5.6) 1 (1.3) 8 (9.2) 0.04*
  Peripheral artery disease 2 (1.2) 0 (0.0) 2 (2.3) 0.50
  Previous stroke/TIA 5 (3.1) 3 (4.0) 2 (2.3) 0.66
  Chronic kidney disease 44 (27.2) 17 (22.7) 27 (31.0) 0.23
Current medication, n (%)
  Aspirin 155 (95.7) 69 (92.0) 86 (98.9) 0.05
  P2Y12 inhibitors 120 (74.1) 51 (68.0) 69 (79.3) 0.10
  Beta-blocker 130 (80.2) 58 (77.3) 72 (82.8) 0.39
  ACEI/ARB 105 (64.8) 51 (68) 54 (62.1) 0.43
  Non-dihydropyridine CCB 1 (0.6) 0 (0.0) 1 (1.1) 0.35
  Nitrates 81 (50.0) 29 (38.7) 52 (59.8) <0.01*
  Statin 156 (96.3) 72 (96.0) 84 (96.6) 1.00
  Mineralocorticoid antagonist 18 (11.1) 3 (4.0) 15 (17.2) <0.01*
Resting ECG, n (%)
  Number of leads having STD, Mean ± SD 2.48 ± 2.66 1.09 ± 1.80 3.68 ± 2.70 <0.01*
  Summation of leads having STD (mV), Mean ± SD 0.37 ± 0.56 0.13 ± 0.24 0.58 ± 0.66 <0.01*
  STE in aVR, n (%) 51 (31.5) 6 (8.0) 45 (51.7) <0.01*
  STE in V1, n (%) 60 (37.0) 13 (17.3) 47 (54.0) <0.01*
  Anterior STD, n (%) 14 (8.6) 3 (4.0) 11 (12.6) 0.06
  Lateral STD, n (%) 67 (41.1) 9 (12.0) 58 (66.7) <0.01*
  Inferior STD, n (%) 25 (15.4) 6 (8.0) 19 (21.8) <0.01*