Article Category: Clinical report
Published Online: Dec 28, 2023
Page range: 287 - 290
DOI: https://doi.org/10.2478/abm-2023-0072
Keywords
© 2023 Soraya Thaivanich et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Background
Dengue virus infection is an intriguing illness. It is traditionally thought of as a self-limited and nonpersistent disease.
Objectives
We report a case with persistent dengue virus genome detectable in hematopoietic cells of a person with remote infection.
Methods
A patient with multiple myeloma in remission was prepared for peripheral blood stem cell (PBSC) transplantation. Plasma and G-CSF-stimulated, mobilized PBSCs were collected. Dengue-specific reverse transcription polymerase chain reaction (RT-PCR) was performed in both pre- and post-stimulated blood specimens. Anti-dengue antibodies by ELISA and by neutralization assay were measured before and after the stem cell mobilization.
Results
The viral genome was detected only in the PBSC of the post-G-CSF-stimulated specimens. Anti-dengue antibodies were negative and positive, by ELISA and neutralization assays, respectively, both before and after stem cell mobilization.
Conclusion
Our findings reveal a persistent infection. Whether and how this strain may interact with subsequent serotype(s) remains to be elucidated.